Posted by admin on Jun 30, 2018 in |
Now a day’s establishing and sustaining competitive advantage depends on the effective development of Knowledge Absorptive Capacity (KAC) and innovations. This study evaluated the role of prior technical experiences in developing firm’s absorptive capacity and the contribution of this type of capacity to the firm’s innovation performance. In this study we designed a questionnaire to assess firms’ KAC and innovation performance. First, the validity and reliability of the questionnaire were assessed. The data were collected from owners/managing directors or research and development managers of 20 Iranian pharmaceutical and biopharmaceutical companies. The following variables were measured: industrial and technical experiences of owners/managing directors and the members of research and development teams, KAC, innovation performance indices and control variables. The questionnaire had appropriate validity and reliability. The findings indicated that the breadth and the depth of the owner’s/managing director’s industrial experiences properly reflected KAC of a pharmaceutical company. In turn, the present research showed that the absorptive capacity of a firm could affect its innovation performance. Organizational strategic regeneration and innovation...
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Posted by admin on Jun 30, 2018 in |
The present work was planned to study the effect of methyl parathion an organophosphate compound (OP) on biochemical contents of fresh water cat fish Heteropneustis fossilis. The exposure of fish to the sub-lethal concentrations of the toxicant methyl parathion was investigated and the variations were observed in biochemical contents in different tissues of the fish i.e. gill, liver, intestine, muscle and brain. The quantitative variations were observed in proteins, carbohydrates and ninhydrine positive substances at different time intervals i.e. 24, 48, 72 and 96 h. The results revealed that the components of proteins, carbohydrates and ninhydrine positive substances were found to be decreased significantly at different time intervals of methyl parathion exposure to different tissues of fish compared to control. The maximum decrease in proteins followed by ninhydrine positive substances (free amino acids) and carbohydrates was observed at 72 h and 96 h compared to 24 h and 48 h in different tissues of the fish H. fossils. Thus, our present investigation reports that the changes observed were depending...
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Posted by admin on Jun 30, 2018 in |
A High-Performance Liquid Chromatography (HPLC) technique has been developed for the determining of foreign impurities in the parent substance of carboren. We have proposed the most sensitive, selective and also the universal HPLC method to be used, which would allow to conduct the qualitative and quantitative analysis under the same conditions so that to determine foreign impurities in the substance. Reliable separation of carboren and impurities was performed on a liquid chromatography equipped with a spectrophotometric detector and an analytical stainless steel column (250 × 4, 6 mm) of size, filled with C18 sorbent (5m km), in gradient elution mode. The detection of limits for carboren and identified of potential organic impurities were determined. It was found that the content of any other individual impurity did not exceed 0.1%, the total content of impurities did not exceed 0.5%. In the samples, impurities A, B and C were detected with a relative retention time of 0.35; 0.42 and 0.30. The results were repeatedly reproduced in model mixtures, parent substance...
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Posted by admin on Jun 30, 2018 in |
Nanoemulsions are the novel drug delivery system which allows sustained or controlled release of drug, biological active ingredient and genetic material. Nanoemulsion is a system consisting of oil, surfactant and an aqueous phase, which is an isotropically clear and thermo-dynamically or kinetically stable liquid solution, usually with droplet diameter within the range of 10 – 500 nm. Nanoemulsion is one of the supreme and valuable dosage forms with the appliance of nano-technology in pharmaceutical formulations. Very small size droplets of the nanoemulsion support better drug absorption and targeting. It not only improves the conventional emulsion systems but also opens new opportunities for other drugs to be designed more precisely with better bioavailability and accurate dosing leading to minimum side effects. The purpose of this research was to develop nanoemulsion of itraconazole that leads to higher dissolution rate and improved bioavailability. Itraconazole nanoemulsion was prepared by solvent displacement method and characterized by particle size determination, polydispersity index, drug content, entrapment efficiency and % cumulative release. The results obtained reveals that...
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Posted by admin on Jun 30, 2018 in |
Chlorophyll and carotenoids are important photosynthetic pigments found in higher plants, cyanobacteria and algae. Carotenoids are responsible for bright red, yellow and orange color in many fruits and vegetables. These two pigments play an important role in plant health. Chlorophyll and carotenoids are reported to contain anticancer properties. Chlorophyll and carotenoids protect skin and help in normal blood clotting, hormonal balance and in deodorization. Chlorophyll and carotenoids have healing effects on oxidation and inflammatory conditions and has great antioxidant properties also. The primary objective of this comparative study is to find out the plant which contains high amount of chlorophyll and carotenoids as these two bioactive compounds has great applications in herbal medicine. In the present course of study, chlorophyll and carotenoids were extracted from the leaves of 21 medicinal plants using 80% acetone and quantified by Arnon method (1949) and Lichtenthaler and Wellburn method respectively. The results revealed that among the 21 medicinal plants under this study, Cocos nucifera (Tree) contains highest amount of total chlorophyll and total...
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