Posted by admin on Aug 31, 2018 in |
Internationally there has been research on large scale for determination of efficiency of cigarette filters but in India it still remains a topic of discussion. Being the second largest consumers of tobacco and tobacco products and one of the largest and fastest growing consumers of cigarettes, such studies need to be undertaken at a greater level to assess the risk and hazards of cigarette smoking. The government of India seems to focus more on the taxation policy on tobacco products with a view that increased taxes on tobacco products will make it difficult for common masses to consume them. However, the Global Adult Survey conducted by the Government of India, Ministry of Health and Family Welfare clearly indicates that despite of increased taxes on tobacco and tobacco products, the number of consumers have grown many folds in last one decade. Most of the researches have used smoking machine regime for determination of human smoke yields from spent filter, however as per the WHO, no smoking machine can actually mimic...
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Posted by admin on Aug 31, 2018 in |
Buccal tablets are prepared by direct compression method using different polymers like carbopol, hydroxypropyl methylcellulose and sodium alginate. Nine formulations were prepared while (F1) to (F3) were prepared by taking individual concentrations whereas all the remaining formulations were prepared by taking combinations of polymers. Aim of study is to develop and optimize mucoadhesive buccal tablets of candesartan by direct compression method. All the batches were evaluated for thickness, weight variation, hardness and content uniformity. In-vitro release study is carried and release mechanisms were explored. Individual carbopol concentration (F1) has high swelling index with low water absorption ratio. Individual concentration of sodium alginate (F3) obtained high drug release, while low concentration of carbopol and high concentration of hydroxypropyl methylcellulose in combinations (F4) gave 86% drug release and with equal ratios of carbopol and hydroxypropyl methylcellulose (F7) gave 88% drug release. But low concentration of hydroxypropyl methylcellulose and high concentration of sodium alginate (F5) in combination form gave 95% drug release. While equal ratios of both hydroxypropyl methylcellulose and sodium alginate...
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Posted by admin on Aug 31, 2018 in |
Background: Metabolic syndrome has a significant impact on the severity and prognosis of various risk factors that may contribute to cardiovascular events. We examined the clinical profile and prevalence of MetS among MI patients along with the estimation of associated risk factors and determined the components of the MetS which conferred the paramount cardiovascular risk. Methods: A prospective observational study was conducted for duration of 10 months on a total of 117 MI patients who were further categorized based on IDF criteria for MetS at a tertiary care hospital in India. Statistical analysis of collected data was done using SPSS 22 for windows version. Results: Among all the parameters used for defining MetS, positive predictive value was highest for fasting blood sugar (p=0.001) followed by high blood pressure (p=0.005) and elevated triglycerides (p=0.850). MetS was significantly more prevalent in MI patients with a prevalence of 51.28% (p<0.001). Conclusion: The study depicted high prevalence of MetS among MI patients which implies greater risk of developing cardiovascular diseases. A systematic approach...
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Posted by admin on Aug 31, 2018 in |
A series of (Z)-3-((1H-benzo[d]imidazol-2-yl)methyl)-substituted thiazolidine-2,4-dione (9a-n) have been synthesized and evaluated for their mycobacterium inhibitory activity against Mycobacterium tuberculosis H37Rv strain. The structures of the newly synthesized compounds were characterized by FTIR and NMR spectral analysis. Most of the synthesized compounds showed moderate to good anti-tubercular activity. Among these compounds 9a, 9d, 9f and 9g have displayed good anti-tubercular activity (MIC 6.25 μg/ml). Further, the molecular docking studies were carried out in order to rationalze the biological...
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Posted by admin on Aug 31, 2018 in |
A simple, economical, accurate and precise high performance liquid chromatographic method was developed and validated for the determination of rifabutin. A Shimadzu LC-2010C HT version 3.01 system using a C-18 column with dimensions of 250 × 4.6 mm and silica particle size of 5 μm. Isocratic elution was employed with methanol, acetonitrile and water (75:25 v/v) were used. The flow rate was 1 ml/min, and effluents were monitored at 242 nm. The HPLC method was extensively validated for linearity, accuracy, precision (Interday precision, Intraday precision), repeatability and robustness. The exalted results receive of a drug were procured all significance values were established to be under the acceptable range in International Conference of Harmonization (ICH) guidelines requirements. The results demonstrate that the developed HPLC modus could be successfully used up for identification and quantification of Rifabutin in any form of the drug, with high resolution, accuracy, and...
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