Posted by admin on Jul 31, 2018 in |
Cordia dichotoma Linn. belonging the family Boraginaceae is locally called as Lasora in India. It is an important drug to cure diseases of the kidney, liver, spleen, heart and blood which attribute many medicinal properties in Ayurveda. The purpose of this study is to identify and characterize the bioactive principle from the bark of Cordia dichotoma Linn. Phytochemical screening methanolic extract of bark of Cordia dichotoma Linn. was done and showed the presence of phytosterol. Phytosterols were isolated from the methanol extract by admixing 100 g of extract with 200 ml of acetonitrile. The resulting white sterol crystals were analyzed by Thin Layer Chromatography and High Performance Liquid Chromatography (HPLC) for the purification. The sterol for structure elucidation was further studied by more sophisticated analytical techniques e.g. FTIR, 1H-NMR, 13C-NMR and LC-MS. After various spectral analysis and interpretation of same, the isolated compound was identified as...
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Posted by admin on Jul 31, 2018 in |
Dexamethasone drug induced the hyperglycemia in the Albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of dexamethasone raised the level of blood sugar in the mice. Administration of aqueous extract of C. citratus root and flower extract reduced the fasting and postprandial blood sugar levels, bringing them towards normal. We were observed anti-diabetic effect both root and flower extracts but the root had better anti-diabetic...
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Posted by admin on Jul 31, 2018 in |
The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Piperacillin (Pip) with potassium hydrogen peroxo-monosulfate in alkaline medium is studied by the increase of forming product light absorbance. A scheme of peroxoacid oxidation and perhydrolysis conjugated reactions of Piperacillin by means of hydrogen peroxomonosulfate is proposed. The procedure of the quantitative analysis of Piperacillin in the combined with Tazobactam pharmaceutical preparation powder of Zopercin® (Piperacillin 4.0 g and Tazobactam 0.5 g) by spectrophotometric – kinetic method is elaborated using triple potassium Caro’s salt solution as a reagent. Peroxomonosulfate acid as triple potassium salt 2КНSO5∙КНSO4∙ K2SO4 (Oxone®) of “extra pure” qualification was used as oxidant. At pH 2-4 for 1 mole of Penicillin, 1 mole of KHSO5 is consumed; the quantitative interaction is achieved within a time of more than 1 min (observation time). The method on initial rates (tangent method) was used to collect kinetic data (usually at 280 nm) by following the appearance product of perhydrolysis reaction of Piperacillin. A solution of sodium hydroxide was thermostated in...
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Posted by admin on Jul 31, 2018 in |
The aim of the present work is to develop the formulation the orodispersible tablets of Serotonin hydrochloride. The tablets were prepared by direct compression technique using microcrystalline cellulose (MCC) as directly compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG) and Crospovidone were used. Method: Using different concentrations of superdisintegrants seven formulations were made and further investigated. The prepared powder mixtures were subjected to both preformulation and physical evaluation studies, and further post compression evaluation parameters including tablet hardness, friability, disintegration time and in-vitro drug release. Results: The pre-compression studies revealed that all formulations were found to be of good flowability. Tablet hardness and friability revealed good mechanical strength. Conclusion: After evaluating all the formulations it has been revealed that the tablets exhibited acceptable properties. According to the present study, it was found that tablets of batch F4 (blend containing CCS & crospovidone (15mg) showed better disintegrating property as well as % drug release (98.78% within 40...
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Posted by admin on Jul 31, 2018 in |
Boerhaavia diffusa is a natural herb possesses potent diuretic, anticancer and antioxidation properties. This work was designed to investigate the effect of hydro alcoholic extract of Boerhaavia diffusa Linn. on hepatoprotective efficacy in D-galactosamine-intoxication in mice. Albino Mice divided into 5 groups each consisting of 6 animals. Group 1 served as vehicle control, Group 2 served as hepatotoxin (D-Galactosamine treated) group, Group 3 served as positive control (Vitamin-E) treated group, Group 4, 5 served as treatment control (200 and 400 mg/kg b.w p.o.) HAEBD. Treatment given for 8 days and D-Gal on last day for all the groups except normal control. D-galactosamine-induced toxicity was manifested by the elevation of serum hepatic marker enzyme activities (Aspartate amino transferase, Alanine amino transferase, alkaline phosphatase and gamma-glutamyl transpeptidase). It also caused significant lipid peroxidation and reduced the levels of antioxidant defense mechanisms. Treatment with HAEBD (200 and 400 mg/kg body weight) orally for 8 days decreased hepatic marker enzyme activities and lipid peroxidation products, lipid hydroperoxides and conjugated dienes, increased the activities...
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