Posted by admin on Jun 30, 2018 in |
Propranolol is beta-blocker and it is widely used in the management of hypertension. Propranolol is used to treat tremors angina, hypertension, heart rhythm disorder and other heart or circulatory conditions. The mucoadhesive buccal tablets of propranolol were papered by wet granulation method using natural polymer like Vigna mungo powder. The compatibility studies of drug and excipient were performed by FT- IR spectroscopy and DSC. After examining the flow properties of the powder blends the results were found to be within prescribed limits and indicated good flowing property, hence it was subjected to compression. The tablets were evaluated for post-compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, surface pH, in-vitro studies like swelling, mucoadhesive strength, residence time and drug release. Formulation (F6) containing Vigna mungo showed good muco-adhesive strength (21.75g) and maximum drug release of 89.31% in 12 h and residence time (6.9 h). The drug content shown 92.19%, surface pH was found to be 6.9. All the evaluation parameters given the positive result and comply with...
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Posted by admin on Jun 30, 2018 in |
Functionality of Ion Exchange Resin (IER) mainly depends on solubility and degree of ionization and molecular weight of drug. For this reason the application of IER is limited to only strong acidic and basic drugs or drug existing as salt; not for weak acidic and weak basic drugs due to their low ionization properties. If we increase the ionization of weak acid and bases, then application of IER will not only be limited to salts or strong acid or strong bases but also for weak acid and bases and hence almost all drugs will be complexed with IER and total exploitation of application of IER can be achieved. Solubility increasing approach such as cosolvent and 2 Hydroxypropyl betacyclodextrin and ionization increasing approach such as keeping the pH above drug ionization constant (pKa) were followed to evaluate their effect on loading of a weekly acidic drug, Repaglinide (taken as model drug) and found that keeping the pH of the complexation medium more than drug pKa had maximum percentage drug loading...
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Posted by admin on Jun 30, 2018 in |
Marine environment is a complex habitat defined by a wide fluctuation in conditions such as pH, temperature, nutrient availability, osmotic pressure and salinity. Because of these various extreme environmental conditions, it harbors varieties of biodiversity such as bacteria, algae, fungi, coral reefs and sea weeds, as compared to terrestrial environment. For adaptation in these conditions marine organisms developed new adaptative strategies like synthesis of secondary metabolites. Exopolysaccharides (EPSs) is one of the important secondary metabolites produced by marine organisms. The present study focuses on the isolation of marine bacteria from different sites of Bhavnagar coast Gujarat, India and screening for EPSs producing marine bacteria by various approaches viz., using fluorescent Calcofluor white dye, Congo-red and trypan-blue agar plate assay method. Quantification of EPSs was done by using phenol-sulphuric acid method for total carbohydrate content. In this work marine bacterial isolate Terribacillus saccharophilus strain PS – 47 gave copious amount of EPSs 1052 µg/ml. Isolate will be further selected for use in various biotechnological...
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Posted by admin on Jun 30, 2018 in |
Introduction: Herbs are the second most commonly used form of complementary and alternative medicine by public. The uses of medicinal herbs continue to increase worldwide. However, clinicians generally have limited knowledge and confidence about using of herbs in medicine. Therefore, this research aimed to assess the level of knowledge and attitude of primary care physicians toward use of medicinal herbs in order to protect the patients from the harmful effects of herbal medicines by increasing the physicians’ awareness regarding it. Method: A cross sectional study, includes 102 primary care physicians at Al-Wazarat health center in Riyadh. Results: 82.4% of the physicians believed that herbs are beneficial for disease management and only 42.2% of them believed that herbs should be used only when conventional medicine fails. 16.7% of the participants suggested that further education about herbs in medicine should be provided to physicians. However, the practice of herbal medicine was low and the level of knowledge was also low as all physicians scored less than 6 correct answers out of...
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Posted by admin on Jun 30, 2018 in |
The objective of this study was to evaluate the antidiabetic activity of methanolic extract of marine algae Sargassum polycystum (MSP) and Gracilaria edulis (MGE) in STZ induced diabetes in rats for Type I diabetic mellitus. The marine algae SP and GE were dried under shade and then powdered, and extracted with methanol. Preliminary phytochemical studies and acute toxicity studies were also carried out on methanolic extract of SP, and GE. After overnight fasting, for type I diabetes was induced in rats by I.P. injection of STZ dissolved in 0.1 M sodium citrate buffer at pH 4.5, at a dose of 65 mg/kg body weight. Group A served as normal control while group B was considered as diabetic control. Group C was standard receiving insulin 4U/kg and Group D diabetic animals were treated with MSP and MGE (250 mg/kg and 500 mg/kg) respectively. During the study, body weight and fasting blood glucose level were taken at 0 and 30th day. At the end of study, animals in all groups were...
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