Posted by admin on May 31, 2018 in |
Sri Lankan Ayurveda clinical practice Satapushpa Shatavari powder (SSP) with or without Satapushpa Shatavari Grita (SSG) enema is used for manage menstrual disturbances due to polycystic ovary syndrome (PCOS). Objective of Present study was to evaluate the efficacy of Satapushpa Shatavari Churna with Satapushpa Shatavari Grita Matra Vasti for the management of PCOS by an open label comparative clinical trial. Successful screening 60 PCOS participants were randomly divided into three groups (n = 20) viz Group A (Oral Administration of SSP 05g t. d. s. with 10 ml of cows ghee for 2 weeks), Group B (Rectal Administration of SSG as enema, 60 ml / day for 2 weeks with 1 week gap) and Group C (oral and rectal administration of SSP and SSG drugs respectively). After one month administration period participants in group A, B and C were assessed on PCOS appearance of the ovary, volume of the ovary, endometrial thickness by US scan. Further volume of menstrual flow, intermenstrual period and hirsutisum was assessed by standard scoring...
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Posted by admin on May 31, 2018 in |
The effect of four extracts of Solanum chrysotrichum on the proliferation of bacteria, yeasts, mouse spleen cells and human transformed cells was determined. Dry leaves grounded were consecutively macerated 24 h with hexane, chloroform, methanol and water. Dilutions of 1, 10 and 100 µg/mL / DMSO were used for the assays with normal mouse spleen cells, DU-145 and MCF-7 cells. The cellular proliferation was evaluated by the sulforhodamine method´s. Antibacterial and antifungal activities were determined by methods of diffusion and dilutions, using concentrations of 10, 15, 20 and 25 mg/mL. The bacteria used were Escherichia coli SOS, Proteus mirabilis NCTC2896, Staphylococcus aureus ATCC6538 and Bacillus subtilis. The yeasts were Candida albicans, Candida tropicalis and Cryptococcus neoformans. The bacteria were cultured in Agar-Mueller-Hinton and the yeasts in Sabouraud Agar and incubated at 37 and 28 ºC, respectively 24 h. Methanol and watery extracts at dosage assayed caused a cellular concentration reduction average of 56 and 59%, on cells DU-145, respectively. The chloroform extract at doses of 100 µg/mL increased to...
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Posted by admin on May 31, 2018 in |
Objective of the present study is to investigate the chemical composition of methanol extract of stem bark of Ficus benghalensis Linn. (Indian Banyan Tree). Shade and air dried stem bark were powdered and extract was prepared according to selective sequential extraction using different solvents of increasing polarity. Methanol extract of stem bark of this plant was further subjected to gas chromatography and mass spectrometry as to the best of authors’ s knowledge no published literature exist about the characterization of chemical constituents of methanol extract by GC-MS technique. Total 63 compounds were reported by GCMS studies out of which two were never reported earliar. Qualitative and quantitative presence of different biologically important phytoconstituents were reported and two new phytoconstituents were investigated. Results of this study suggested the phytopharmacological importance of reported constituents of stem bark extract of Ficus benghalensis Linn. and justify the use of Ficus benghalensis Linn. in ancient literature of...
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Posted by admin on May 31, 2018 in |
A new, simple and low cost spectrophotometric method for the determination of teneligliptin, a new DPP IV inhibitor drug in bulk and pharmaceutical dosage form using sodium nitroprusside was developed. The absorbance maximum (λmax) of the resulted colored product was at 445 nm. As different solvents were tried methanol was found to be the most suitable solvent. The Beer’s law has been obeyed in the concentration range of 4 – 20 µg/ml with the detection limits of 0.09µg/ml and limit of Quantification of 0.28µg/ml. The correlation coefficient was found to be (r = 0.9999). The reaction ratio between teneligliptin and sodium nitroprusside was studied and found to be 1:1. The method was validated and results obtained for the assay of two different brands of teneligliptin tablets were compared. The repeatability and reproducibility of the developed method were evaluated and the obtained results...
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Posted by admin on May 31, 2018 in |
Antioxidants are one of the key troupes in tumorigenesis, several natural and artificial antioxidants were shown to have anticancer effects. The aim of the current study is to reveal the chemopreventive nature of citral during diethylnitrosamine (DEN) -induced liver cancer in male Wistar albino rats. Administration of DEN to rats caused in amplified relative liver weight and serum marker enzymes aspartate transaminase (AST), alkaline phosphatase (ALP), alanine transaminase (ALT), lactate dehydrogenase (LDH) and gamma glutamyltranspeptidase (γGT). The levels of lipid peroxides prominent (in both serum and tissue) with a succeeding reduction in the final body weight and tissue antioxidants like superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR). Citral supplementation (100 mg/kg body weight) knowingly reduced these alterations, thereby showing powerful anticancer effect in liver cancer. Histological interpretations revisions were also conceded out, which supplementary supports to the chemopreventive action of the citral against DEN induction during liver cancer progression. These explanations suggest that citral inhibits lipid peroxidation, hepatic cell damage, and...
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