Posted by admin on Apr 30, 2018 in |
The present study was carried out to evaluate antidiabetic as well as in-vivo and in-vitro antioxidant activities of n-hexane fraction of Tamarindus indica Linn. seed (T. indica) in streptozotocin (STZ) induced diabetic rat. Oral administration of n-hexane fraction at the dose of 100 mg/kg body weight for 28 days prevented significantly the STZ-induced hyperglycemia. The plasma insulin and C-peptide levels as well as activities of antioxidant enzymes such as catalase (CAT), peroxidase (Px) and superoxide dismutase (SOD) in the hepatic tissue were found to be decreased in diabetic animals which were corrected after the treatment of n-hexane fraction of hydro-methanolic extract of T. indica. Oral glucose tolerance test (OGTT) reveals that the fraction at above mentioned dose showed a significant decrease of blood glucose level in normal and diabetic rat. Histopathology of pancreas was performed after n-hexane fraction treatment to diabetic rat and the results were compared with the control as well as diabetic groups. To evaluate the free radical scavenging activities of the n-hexane fraction following in-vitro study...
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Posted by admin on Apr 30, 2018 in |
In this present research work, the aim was to develop ileo-colonic targeted mini-tablets filled capsule system of flurbiprofen for treatment of rheumatoid arthritis. In the present study pH independent colon targeted system was developed and evaluated. SMEDDs of poorly water soluble drug flurbiprofen were prepared to enhance its dissolution rate and bioavailability. Mini-tablets of flurbiprofen were also prepared and filled in capsule. This capsule was coated with ethyl cellulose. Based on in-vitro dissolution studies it was noted that ethyl cellulose release takes place in colon (colon targeted). The design of formulation hence ensured colon targeted delivery of drug preventing premature drug release in stomach or small intestine and enhanced dissolution rate for enhancement of bioavailability. In vitro release studies were carried out in 0.1 N HCl pH 1.2, phosphate buffer pH 7.4 and phosphate buffer pH 6.8 mimicking in-vivo conditions for dissolution. SMEDDS exhibited a considerable increase in solubility of flurbiprofen and selected colon targeted formulation of pure drug successfully achieved colonic release of flurbiprofen with a lag time...
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Posted by admin on Apr 30, 2018 in |
Background: Alcoholic liver disease is a spectrum of alcohol induced injury that includes fatty liver, alcoholic hepatitis and alcoholic cirrhosis. Corticosteroids are used in cases of severe alcoholic hepatitis with Maddrey’s Discriminant Function score > 32. However, many of the patients who are being managed by corticosteroids are non responders and mortality increases in such patients. Lille model is a prognostic model which helps in identification of steroid responders and non responders within 7 days of start of treatment. In the present study we identified the alcoholic hepatitis patients with Lille score < 0.45 and with > 0.45. Survival in the patients was compared with the Lille score. Method: Prospective study of 100 patients of alcoholic hepatitis aged 18 to 85 years was done for a period of six months. All of the patients were managed with similar treatment protocols including general supportive measures and treatment of associated complications. Oral or Intravenous corticosteroid therapy was given for 28 days and then tapered off over next two weeks in the...
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Posted by admin on Apr 30, 2018 in |
Membrane electrochemical potential or zeta potential (ZP) is a feature of the molecular profile of the cell membrane and the two-dimensional arrangement of its charge-bearing molecules. Plasmodium species, the causative agents of malaria, are intracellular parasites that remodel host erythrocytes by expressing their own proteins on erythrocyte membranes. In the present study the variation in the ZP of erythrocytes of malaria patients was studied by comparing it with that of the normal healthy volunteers. The ZP of erythrocytes was measured by the cell electrophoresis technique using Zeta Meter System 4.0 at the minimum voltage required for the movement of the erythrocytes to travel a fixed distance. For healthy volunteers the average ZP value of the erythrocytes was found to be 22.57 ± 0.2984 mV and for malaria patients it was found to be 13.09 ± 0.8456 mV. The results revealed that there is a significant decrease in the ZP of the erythrocytes of malaria patients as compared with that of the healthy volunteers. Thus it can be concluded that...
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Posted by admin on Apr 30, 2018 in |
Background: Menstrual disorders frequently affect the quality of life of adolescents and young adult girls and can be indicators of serious underlying problems. Objectives: Study aims to determine the prevalence and pattern of menstrual disorders in adolescents and their effect on everyday life. Design: A cross sectional study design was adapted. Settings: Government and private schools of Arifwala city, District Pakpattan, Punjab, Pakistan. Materials and Methods: All girls between the age of 10 – 19 years were included in the study during the period, June-2016 to December-2016. Convenient sampling technique was used to select the schools, and to enroll the study participants, stratified sampling was utilized. A total of 1000 girls participated in the study. Main outcome measures: To determine the prevalence and pattern of menstrual disorders and their effect on everyday life. Results: Results showed that, significant relationship was found between age and dysmenorrhea (P < .001), irregular menstruation (P = .001), secondary amenorrhea (P = .005) and between BMI and dysmenorrhea (P =.004) and regular menstruation. (P...
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