Posted by admin on Mar 31, 2018 in |
Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of immunomodulatory activity were carried out by using Carbon Clearance Test and Delayed Type Hypersensitivity Test. Result: Oral administration of all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. significantly (P < 0.0001) showed an increase in phagocytic activity and DTH response in Rat at an experimental dose. The study also comprises the acute toxicity study and preliminary phytochemical screening. Conclusion: The study demonstrate that all the extract of Rumex vesicarius Linn. and Symplocos racemosa Roxb. shows the significant immunomodulatory effect on both humoral as well as cell-mediated...
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Posted by admin on Mar 31, 2018 in |
In the present investigation, fluorescently labelled sulfated polystyrene beads were coated with oppositely charged polyelectrolytes {i.e. Poly diallyl dimethyl ammonium chloride, Poly (sodium 4-styrene sulfonate)} through an electrostatic interaction by using layer by layer assembly method. Doxorubicin is a model anticancer drug with protonatable amine group that acquires net positive charge in an acidic environment. The positively charged doxorubicin was electrostatically bound onto the surface of polystyrene beads coated with Poly (sodium 4-styrene sulfonate) as an outer layer. This model drug loaded nanocarrier was characterized by optical spectroscopy. In addition, gel electrophoresis principle was used to track the polyelectrolyte coating on the surface of the negatively charged polystyrene beads. The layer by layer method of coating drug molecule on the surface of polyelectrolyte coated nanoparticles was also confirmed with size and zeta potential measurements by using dynamic light scattering. The correlation between the movement of polyelectrolytes coated nanoparticles in gel electrophoresis and size of the nanoparticles measured by dynamic light scattering were also studied. The results suggest that layer...
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Posted by admin on Mar 31, 2018 in |
Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin, followed by ring opening reaction of epoxy positioned at 1st and 2nd carbon in the chemical structure. It was characterized by NMR, seven -CH2 (position 10, 11, 9, 8, 6, 4 and 2) carbons present at negative side. Tertiary carbons are present at chemical shifts 39 ppm and 70 ppm (position at 7 and 3) and primary carbons are present at chemical shifts 10 ppm and 13 ppm (position at 14 and 12). Both primary and tertiary carbons were found on the positive side of the spectrum. From FTIR studies, peak corresponding to -OH stretch is observed at 3,391 cm-1 and the -OH bending is seen at 1,111...
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Posted by admin on Mar 31, 2018 in |
Hypothyroidism and Hyperthyroidism are the two primary pathological conditions that involve the thyroid gland. Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Accurate measurement of thyroid hormone concentrations is the key for proper diagnosis of thyroid gland dysfunction. This article is mainly focused on the effect of food on serum levels of Thyroid profile (TSH, FT3 and FT4) and preference of blood sample for Thyroid Profile in diabetic patients. An observational cross sectional study was done on 120 Diabetic patients attending OPD of our hospital for regular health checkup. Thyroid profile was done on the fasting and postprandial samples. The values of TSH, FT3 and FT4 in postprandial samples were decreased as compared to fasting samples which were significant statistically with p- value less than 0.05 in all the parameters. Hence from our study, it can be stated that Thyroid profile in fasting state would be more beneficial for proper diagnosis of thyroid...
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Posted by admin on Mar 31, 2018 in |
Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyesters were characterized by solubility and viscosity measurements. The structure of the copolyesters was established by FT-IR, 1H NMR, 13C NMR and MALDI. The monomer and copolyesters were studied for their anticancer activity using MCF-7 Cell Line and their cytotoxic effect were studied on VERO Cell Line by MTT assay. The IC50 values were calculated using the Software Graph Pad Prism Version 7 and ED50 plus v 1.0. The Selectivity index indicates that the chalcone HHEP and the two copolyesters are good anticancer agents and the chalcone MHEP is cytotoxic. The Selectivity index were found to be more than two, these copolyesters can be targeted individually or in combination with cancer drug in...
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