Posted by admin on May 31, 2018 in |
Background: In the present study, our objective was to determine whether nebulized colistin as an adjunctive therapy to conventional intravenous antibiotics of Ventilator-associated pneumonia (VAP) caused by multi-drug resistant (MDR) was safe and beneficial in critically ill patients. Methods: A prospective matched case-control study was performed at the ICUs of the University Hospital of Isfahan, Iran, from January to June 2017. Twenty patients with VAP due to MDR gram-negative bacilli received nebulized colistin and were matched on the basis of age and acute physiology and chronic health evaluation II (APACHE) score with 20 control patients who had received systemic antibiotic therapy according to their responsible physicians. Results: The baseline characteristics of the patients and conventional therapy of VAP in both groups were comparable. Most of the cases of VAP were caused by MDR A. baumannii (N=25, 75%) and Klebsiella pneumonia (N=10, 50%). No significant difference between the groups were observed regarding clinical cure (P: 0.6) and mortality (P: 0.25). The rate of pathogen eradication was significantly better in case...
Read More
Posted by admin on May 31, 2018 in |
Neurodegenerative disease is the condition of brain cells that lose of its ability to generate the neurotransmitters and this leads to the accumulation of proteins in the brain. These condition causes memory loss and problems in the cognitive functions. Neurological diseases are characterized by four major types such as Alzheimer’s disease, Parkinson’s disease, Huntington disease, Amyotrophic lateral sclerosis. Parkinson’s disease is a second neurological disorder, characterized by a selective loss of dopaminergic neurons in the substantianigra, causing a subsequent reduction of dopamine levels in the striatum. Loss of dopaminergic neurons in striatum causes imbalance of neurotransmitters like acetylcholine and dopamine, resulting in the Parkinson’s disease. Tremor, rigidity, dyskinesia are the primary symptoms and memory loss, sleeps disorders, cognitive impairments are the secondary symptoms of Parkinson’s. Aim: To investigate the structural changes in silico docking was performedwith target protein LRRK2 with the following compounds theaflavin, baicalein, sesamol, tenuigenin, gastrodin, phloroglucinol and L-DOPA. Methods: The in silico docking was carried out using autodock version 4.2. Rasmol tool was used to visualize...
Read More
Posted by admin on May 31, 2018 in |
Imidazolidine are five-member heterocyclic compounds having two nitrogens in the ring. There are two carbonyls in the ring, one of them between the two nitrogens. The five positions of the ring are numbered and, as such, there are four points of functionality, one at the 1 position, one at the 3 position and two at the 5 position in their ring structure respectively and thus exhibiting potent as well as wide range of pharmacological activities. A series of, phenylene methylene hydantoin were synthesized. Benzaldehyde derivatives reacted with imidazolidine to yield the respective derivatives. This reaction follows the Knoevenagel condensation reaction mechanism by which ethanolamine abstract a proton from heterocyclic ring and a carbanion ion is generated. The structure of synthesize compounds were supported by IR, NMR and mass spectral data. The synthesized compounds were screened for their in vitro antidiabetic activity by α-amylase, α-glucosidase inhibition, glucose diffusion inhibitory test and the potential compounds tested for in vivo activity by blood glucose changes in type 2 diabetic...
Read More
Posted by admin on May 31, 2018 in |
Aspirin is a common medication used to treat pain, fever and inflammation. It shows the property of polymorphism and two polymorphic forms were characterized till now (Form I and Form II). Albendazole is another common medication used for the treatment of variety of parasitic worm infestations. This drug also shows polymorphism where two forms (Form I and Form II) of it were characterized till date. Various commercial aspirin and albendazole tablets were collected, powdered and after proper clean up procedure their melting points were determined to identify the polymorphic form of each drug sample. The detection of polymorphic form was further carried out by infra red spectral analysis. It was found that all the commercial aspirin samples under study belong to the polymorphic form II which is usually used in drug formulation. Polymorphic studies on commercial albendazole tablets showed that all the samples under investigation belong to the polymorphic form I which is commonly...
Read More
Posted by admin on May 31, 2018 in |
Exacum lawii is folklore medicinal herb, boiled with oil and used traditionally for ocular infection. The aim of the present study is to evaluate the in-vitro antibacterial and antifungal activity against ocular infection. Ethanolic extract, petroleum ether extract and volatile oil were extracted from Exacum lawii whole plant. Antibacterial activity and antifungal activity against strains causing ocular infection were evaluated and Himalaya Optha-care Eye Drop was used as standard. The antimicrobial susceptibility was performed by agar disc diffusion assay method. The minimum bactericidal concentration (MBC) and minimum fungicidal concentration were determined for each extract and volatile oil by subculturing the samples. The volatile oil and the extracts of Exacum lawii showed bactericidal and fungicidal activities against some strains of bacteria and fungi causing ocular infection. Minimum bactericidal concentration for volatile oil was found in range of 3.125 mg/ml to 12.25 mg/ml, for ethanolic extract 6.25 mg/ml to 25 mg/ml and for petroleum ether extract 25 mg/ml to 50 mg/ml. Minimum fungicidal concentration of volatile oil was found to be...
Read More
