Posted by admin on Feb 28, 2018 in |
Lipid metabolism in animals has recently gained growing interest among researchers. Among organic compounds, it is only protein and nucleic acids that for a long time have remained in primary focus of research, though lipids are now known to be essential for the origin of life and development of organic forms. Metabolic processes are very active in the bodies of high-producing cows. Large amounts of energy and nutrients are utilized to synthesize milk; all body systems function intensely. Consequently, there are increased demands for adequate supply of energy and all nutrients including lipids. Insufficient or excessive intake of the latter leads to disruption of metabolism, lower productivity, and deterioration of animal health. At present, there is some controversy in the Russian and foreign literature in regard to on the optimal fat content in the dry matter of the rations of lactating cows, especially high-producing ones. Researchers recommend rather wide ranges of fat concentrations in the diets. The issue that remains insufficiently explored is the effect of various fat levels...
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Posted by admin on Feb 28, 2018 in |
The objective of the present study is to carry out the photochemical investigation and hepatoprotective activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn. belongs to the family Scrophulariaceae and have ruminate medicinal properties. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts (PEESD, CESD and EESD) were then taken for preliminary phytochemical screening using standard methods. The hepatoprotective activity of the different extracts of Scoparia dulcis was evaluated by using carbon tetrachloride induced liver damage in experimental rats. In hepatotoxicity induced animals, an oral dose of 300 mg/kg, of the petroleum ether, ethanol and chloroform extracts of Scoparia dulcis exhibited a compelling decrease in marker enzyme levels and increased levels of antioxidant enzymes. In the above dose the plant extracts produced a significant decrease in the Lipid peroxidase levels in the tested animals against Carbon tetrachloride induced liver toxicity. The chloroform extract was found rich in phytochemical constituents and had the highest hepatoprotective activity. From the...
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Posted by admin on Feb 22, 2018 in |
The current treatment of inflammation includes NSAIDs, selective COX-2 inhibitors, glucocorticoids and anti-TNFα has peptic ulcer, renal and hematological toxic side effects as well as some of these drugs are more expensive. Hence it is necessary to evaluate the new cost effective as well as less toxic drug. Aloe vera showing a lots of promise and hence researcher all over are trying to harness the anti-inflammatory potential of Aloe vera. Objective: To study the anti-inflammatory and immunomodulatory activity of Aloe vera gel extract. Methodology: The anti-inflammatory activity was evaluated by using carrageenan induced rat paw edema model for acute inflammation and cotton pellet granuloma for chronic inflammation and to evaluate the ulcer potential. The immunomodulatory activity was evaluated by phagocytic activity of Polymorphonuclear cells (PMNs) on Candida cells. Results: The Aloe vera gel extract in the doses of 100mg/kg, 200mg/kg, show significant anti-inflammatory activity while 400mg/kg show equal anti-inflammatory activity as that of Aspirin on acute model of inflammation. Aloe vera gel is not having ulcer potential as that...
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Posted by admin on Feb 19, 2018 in |
The aim of study is to develop microsponge based delayed release dosage form, technique used to manufacture microsponge was quasi emulsion diffusion technique. Eudragit L 100 and Eudragit S 100 polymer is used to incorporate lansoprazole in microsponge. Lansoprazole is acid labile drug hence release of lansoprazole was delayed from acid environment. Microsponge contains porous polymeric microspheres, typically 100 – 250 μm in diameter. Compatibility of the drug with adjuncts was studied by DSC. Production yield, loading efficiency, particle size analysis, surface morphology and in-vitro release studies were carried out. Optimized microsponge blended with other diluents and filled in capsules. Blend containing lansoprazole Microsponge were evaluated for SeDeM parameters to check its flow. The microsponge formulation F2 showed delayed release of lansoprazole in buffer stage pH 6.8 bypassing the acidic stage. The result reveals that developed microsponge are cost effective and can be used as a delivery system for acid labile drug lansoprazole to avoid its degradation in acidic media of the stomach. SeDeM technique can be employed for...
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Posted by admin on Feb 11, 2018 in |
Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortality in health care. Method: A prospective, observational study conducted was performed on 120 patients. Patient age more than 18 years of either gender and diagnosed with the psychiatry disorder were enrolled in the study. Result: Total 120 patients were enrolled and five type of DRPs were obtained during the study, ADR 24 (44.4%), drug-drug interaction 6 (11.1%), overdose 12 (22.2%), sub-therapeutic dose 6 (11.1%), failure to receive drug 6 (11.1%). Out of 103 Interventions, 54 (52.4%) suggested recommendation were accepted by the psychiatrists. Conclusion: The overall study suggested that the clinical pharmacist has a huge scope and it is an integral part of the health care team. The clinical pharmacist has greater responsibility...
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