Posted by admin on Apr 30, 2018 in |
Ten, 2-substituted benzimidazole derivatives were prepared and assessed against two Gram-positive bacteria (Streptococcus mutans, Staphylococcus aureus) and two Gram-negative bacteria (Psuedomonas aeruginosa, Escherichia coli). The derivatives were obtained by the condensation of 2-((1H-benzo[d] imidazol-2-yl) thio) acetohydrazide(4) with different substituted aromatic aldehydes and their structures were characterized by FTIR, 1H NMR. The compound (E)-2-((1H– benzo [d] imidazole-2-yl) thio)- N´- (furan- 2- yl- methylene) acetohydrazide (6g) showed potent activity against both Gram-positive species (0.2-0.8 µg/ml of MIC) which was better than the standard drug Ciprofloxacin. The derivative (E)-2-((1H-benzo[d]imidazole-2-yl) thio)-N´-(4-methoxybenzylidene) acetohydrazide (6a) was evaluated for potential polymorphism by differential scanning calorimetry (DSC). It was then subjected to crystallization using different solvents. The crystal obtained from acetonitrile solvent displayed different thermal transition (240.82 °C) from that of the parent crystal (234.52...
Read More
Posted by admin on Apr 30, 2018 in |
Background: Cancer is still a dreadful disease, the treatment ranges with difficulties like strong side effects, shortage of donor and organs. In relation, plants and its chemical properties will provide an efficient source in the innocuous treatment for cancers. Objectives: To identify and isolate bioactive compounds from Gloriosa superba tubers and Albizia amara leaves with anti-cancer property that has traditionally been suggested as an anti-proliferative agent in ethnomedicine. Design: G. superba tubers and A. amara leaves are extracted and screened qualitatively. Extracts were then tested for antioxidant by DPPH assay. Highly potential extract with antioxidant are preceded to GCMS. The compounds determined from GCMS were selected according to its non-reported bioactive information on PubChem, and preceded against Hep-G2 and A431 cancer cell by MTT assay. Result: Ethanolic extract showed high antioxidant activity in both the plant extracts, GC-MS analysis was performed with ethanolic extracts revealing ample of phytoconstituent. Six non-reported bioactive compounds were isolated and identified using GC-MS. MTT assay was performed using isolated compounds such as 3-Hydroxy-4-methoxymandelic acid,...
Read More
Posted by admin on Apr 30, 2018 in |
The aim of this research was to develop controlled and sustained release formulation of hydrogel beads containing rabeprazole sodium, and to study the effects of Eudragit S100 coating on the release of rabeprazole sodium. The main objective was to develop a colon targeted drug delivery system to minimize – drug release in the upper gastro intestinal (GI) tract as well as to minimize GI adverse effects associated with NSAIDs. Alginate hydrogel beads of rabeprazole sodium were formulated by ionotropic gelation technique and the variables studied. The prepared Eudragit S100 coated hydrogel gel beads of rabeprazole sodium were characterized by determining particle size, % drug entrapment efficiency, swelling index and in-vitro release study. The mean particle size was found to be increase with the increment in concentration of sodium alginate and decrease in the concentration of calcium chloride. The % drug entrapment efficiency of the prepared hydrogel beads formulations was found in the range of 67.45 ± 0.23 to 82.89 ± 0.64. Swelling time analysis revealed higher swelling time at...
Read More
Posted by admin on Apr 30, 2018 in |
The present study was designed to investigate Analgesic activity of Chloroform extract and isolate 1 of Eulophia ochreata Lindl. and dicholoromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. The analgesic activity was assessed by using acetic acid induced writhing method and hot plate method. In acetic acid induced writhing method the extracts and isolates of both plants was administered intraperitoneally at dose of 200 mg/kg to Swiss-albino mice. Chloroform extract (60.17%) Isolate 1(45.59%) and dichloromethanolic extract (55.48%) and isolate 2(48.07%) of Eulophia ochreata Lindl. and Zingiber cassumunar Roxb. respectively showed significant inhibition as in pain response as compared with standard aceclofenac (51.10%) at the dose of 10 mg/kg. In Hot plate method the extracts and isolates of both plants was administered orally at dose of 200 mg/kg to Swiss-albino mice. The chloroform extract and isolate 1 of Eulophia ochreata Lindl showed significant analgesic activity showing 55.84% and 66.25% when compared to the standard pentazocine(5mg/kg) as 50% at 60 min. Dichloromethanolic extract and isolate 2 of Zingiber cassumunar Roxb....
Read More
Posted by admin on Apr 30, 2018 in |
Conventional ophthalmic preparations exhibit poor bioavailability due to the rapid precorneal elimination of the drug, and the physiological constraints imposed by the protective mechanisms of the eye lead to the low absorption of the drugs resulting in a short duration of the therapeutic effect. In order to increase the residence time of the drug in-situ gelling systems were prepared and instilled as drops into the eye which undergo a sol-gel transition in the cul-de-sac. The present work describes the formulation and evaluation of flurbiprofen ocular in-situ gel, based on the concept of pH – triggered in-situ gelation. Polyacrylic acid (carbopol) was used as the gelling agent in combination with hydroxy-propyl methyl cellulose (HPMC) which acted as a viscosity enhancing agent. The formulations were evaluated for clarity, pH measurement, gelling capacity, gelling temperature, drug content estimation, rheological study, in-vitro drug release study, sterility testing and stability studies. The physicochemical interactions between drug and polymers were investigated by fourier transform infrared (FTIR) spectroscopy. FTIR studies did not show any evidence of...
Read More
