Posted by admin on Apr 3, 2018 in |
Chemometric designs were applied to develop a simple UV-visible spectroscopic method for the simultaneous estimation of Hydrochlorthiazide (HCT), Amlodipine (AMLO) and Telmisartan (TEL) in bulk and solid dosage form. The simultaneous spectroscopic method was developed for the three drugs and the data generated from the spectra were determined by using Chemometric methods such as trilinear regression analysis, Cramer’s matrix method, Method of least squares, Multivariate calibration methods such as partial least square regression (PLS) and Principle component regression (PCR). The wavelengths selected for all the above methods were 270 nm (wavelength of maximum absorption; λmax of HCT), 342 nm (wavelength of maximum absorption; λmax of AMLO) and 292 nm (wavelength of maximum absorption; λmax of TEL). Results: The methods shows good linearity for TEL from 4 – 20 μg/ml, for HCT from 2-10 μg/ml and AMLO from 2 – 10 μg/ml with regression coefficient values of 0.970, 0.996 and 0.980 respectively. The RSD value for intraday and inter-day precision was found to be less than 2%. The percentage recovery...
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Posted by admin on Mar 31, 2018 in |
The present study aimed to green synthesis the nanoparticles using bioactive compounds from unique seaweeds and testing its application for anti-microbial, anti-diabetic, ovicidal, larvicidal and cytotoxic activity. Seaweeds are marine non- flowering plants have much of the secondary metabolites and had not been explored widely. There are very limited amount of literature are there for seaweeds. Steochospermum marginatumis a species of brown algae in the family Phaeophyta, they are found on rocky shores. The green synthesis of silver nanoparticles (AgNPs) was synthesized from the seaweed Steochospermum marginatum. The AgNPs was formed at 60°C at 5000 rpm when the solution of silver nitrate was added to aqueous extract of Steochospermum marginatum. The UV-Visible Spectroscopy, Fourier transform-infrared spectroscopy (FT-IR), Scanning electron microscope (SEM) were used for characterization of AgNPs. The green synthesized silver nanoparticles were tested for various applications such as Anti-microbial, ovicidal, larvicidal and anti-diabetic and cytotoxicity using VERO cell...
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Posted by admin on Mar 31, 2018 in |
Diabetes mellitus or sugar diabetes is a condition that occurs when the body can’t use glucose (a type of sugar) normally. It is a chronic disease associated with abnormally high levels of the glucose in the blood because of disturbances in carbohydrates, fat and proteins metabolism and it is due to one of two mechanisms that inadequate production of insulin (which is made by the pancreas and lower blood glucose), or inadequate sensitivity of cells to the action of insulin. This causes glucose levels in the blood to rise, increased urination, extreme thirst and unexplained weight loss. The prominent objective of this work was to find out the anti-diabetic and anti-hyperlipidemic activities of Origanum majorana ethanol leaf extract (100, 200, 400 mg/kg body weight) in Streptozotocin (50 mg/kg b.w) induced diabetic rats. After oral administration of such extract the blood glucose levels were recorded at specific intervals. In consequence it was observe that extract was significantly diminished blood glucose level. Simultaneously the effect of the extract on diabetes induced...
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Posted by admin on Mar 31, 2018 in |
Coconut shell oil was extracted from raw coconut shells, collected from Thiruvallur District. These were extracted using various solvents based on the polarity which includes ethanol, chloroform, acetone, petroleum ether and aqueous. The antibacterial activity against the growth of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Salmonella typhi was done. The antifungal activity against the growth of organisms such as Epidermophyton floccosum, Aspergillus niger, Penicillium, Microsporum canis, Candida albicans and Aspergillus flavus were tested. The extracts were compared with standards like novobiocin, amoxillin and ketoconazole for antibacterial and antifungal activity respectively. The results indicate that zone of inhibition increased when increasing the concentration of the extracts. Among the five extracts of coconut shell oil the ethanolic extract exhibited maximum antibacterial activity against six bacterial strains. Ethanol and petroleum ether extract showed maximum inhibitory activity against Epidermophyton and Candida albicans. This study showed that coconut shell oil possesses antimicrobial...
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Posted by admin on Mar 31, 2018 in |
Introduction: Menorrhagia that means excessive uterine bleeding is one the most common reasons that women refer to gynecological centers. Despite the use of “Quince paste” in Iranian Traditional Medicine (ITM) clinics, no studies have been done in this regard. Objectives: This study was carried out to investigate the effect of “Quince paste” on uterine bleeding in patients with menorrhagia. Materials and methods: This study was a clinical trial of before-after pilot study conducted on 35 patients aged 18-50 years suffering from menorrhagia. A tea spoonful of “Quince paste” after each meal was prescribed for two months. A pictorial form was completed to determine bleeding volumes and days as well as quality of life questionnaire before and at the end of the intervention. Results: Patients age was 33.8 ± 10.8 years and BMI was 28.94 ± 14.07. Bleeding score decreased significantly after two months of intervention (from 264.2 ± 198.9 to 125.8±155.9), (p<0.001). Quality of life score decreased significantly from 30.28 ± 5.73 to 22.02 ± 3 (p<0.001). Bleeding days...
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