Posted by admin on Mar 31, 2018 in |
Hypothyroidism and Hyperthyroidism are the two primary pathological conditions that involve the thyroid gland. Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Accurate measurement of thyroid hormone concentrations is the key for proper diagnosis of thyroid gland dysfunction. This article is mainly focused on the effect of food on serum levels of Thyroid profile (TSH, FT3 and FT4) and preference of blood sample for Thyroid Profile in diabetic patients. An observational cross sectional study was done on 120 Diabetic patients attending OPD of our hospital for regular health checkup. Thyroid profile was done on the fasting and postprandial samples. The values of TSH, FT3 and FT4 in postprandial samples were decreased as compared to fasting samples which were significant statistically with p- value less than 0.05 in all the parameters. Hence from our study, it can be stated that Thyroid profile in fasting state would be more beneficial for proper diagnosis of thyroid...
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Posted by admin on Mar 31, 2018 in |
Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects. As a part of proactive approach in the fight against breast cancer, two copolyesters using varying chalcone diols as monomer and varying aliphatic and aromatic acid chlorides were synthesised by solution polycondensation method. The two copolyesters were characterized by solubility and viscosity measurements. The structure of the copolyesters was established by FT-IR, 1H NMR, 13C NMR and MALDI. The monomer and copolyesters were studied for their anticancer activity using MCF-7 Cell Line and their cytotoxic effect were studied on VERO Cell Line by MTT assay. The IC50 values were calculated using the Software Graph Pad Prism Version 7 and ED50 plus v 1.0. The Selectivity index indicates that the chalcone HHEP and the two copolyesters are good anticancer agents and the chalcone MHEP is cytotoxic. The Selectivity index were found to be more than two, these copolyesters can be targeted individually or in combination with cancer drug in...
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Posted by admin on Mar 31, 2018 in |
This study aimed to characterize and evaluate chitosan nanoparticles (CSNPs) as a carrier system for the hormone, oxytocin. Ionotropic gelation was the technique used to synthesize the CSNPs. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed narrow particle size distribution of 30-50 nm and spherical particle shape. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), thermal gravimetric / differential thermal analysis (TGA / DTA) and Fourier Transform Infrared Spectroscopy (FTIR) were used to evaluate possible drug-polymer interactions. Data obtained from X-ray diffraction (XRD) showed a decrease in crystallinity due to the disruption of the intramolecular / intermolecular chitosan network and a molecular level of oxytocin dispersion in the O-CSNP matrix. Differential scanning calorimetry (DSC) exhibited further evidence of drug-polymer interaction through observed endothermic shifts. Fourier-transform-infrared (FT-IR) spectra obtained confirmed the presence of oxytocin within the CSNP matrix as well as further proof of the intermolecular interactions existing between oxytocin and chitosan. Loading and release profiles of the O-CSNPs were conducted using LC/MS. The effect of nanoparticle size...
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Posted by admin on Mar 31, 2018 in |
Introduction: Klebsiella pneumoniae is one of the most frequent infection organism following orthopedic surgeries and specifically total hip arthroplasty. Recently, attitude toward herbal medicine is being popular both in people and health care systems. Ruta graveolens is a traditional herbal remedy Iranian medicine and some other countries with a wide spectrum of therapeutic utilities. Our purpose was to determine the effects of this medicinal plant on Klebsiella pneumoniae growth. Materials and methods: Standard Klebsiella pneumoniae was used. We assessed the hexane extracts of both leaf and stark of Ruta graveolens on growth of bacterial disc diffusion and serial dilution methods. We compared the results with some standard frequent chemical antibiotics. Results: Our results showed that all doses of leave extract including 200, 250, 300, 350 and 400 micrograms of stark extract had inhibited the growth. In disc diffusion test 500 μg of hexanic extract prevent the growth of bacteria rather than antibiotic discs. We determined minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) by doing their methods. Conclusion:...
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Posted by admin on Mar 31, 2018 in |
Objective: The flavonoid baicalein, is historically used as an herbal medicine by the Chinese, which produces a wide range of pharmaceutical effects, among which is the potent anticancer activity which has raised a great conflict of interest in the recent years. This study aims to verify the anti-proliferative and the cell viability effects of baicalein on metastasis of MCF-7 human breast cancer cell lines by in-vitro, to investigate the related mechanisms. Methods: MTT assay was used to investigate the anti-proliferative activity of baicalein using MCF-7 cell lines and trypan blue assay method were used to examine the effects of baicalein on cell viability on MCF-7 cell lines. Results: The in-vitro cytotoxicity activity studies were proved that cancer cell lines were inhibited significantly with the increasing of sample...
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