Posted by admin on Dec 31, 2017 in |
A health study was conducted in Northern Region of Bangladesh to determine the prevalence and cause of taking psychotropic drugs. The health survey was involved 615 patients who are taking psychotropic drugs and found 63.58% patient is male and 36.42% is female. The majority of patients are student (45.65%), housewife (19.02%) and service holder (13.33%). The age of patients is 15 – 24 years 35.93% and 25 -34 years 31.38%. Supreme cause of taking psychotropic drug is tension 25.37%, depression 18.21%, sleeping disorder 10.56% and pain 10.24%. The patients are taking anxiolytic drug (59.02%), antipsychotic drug (19.84%) and antidepressant drug (20.65%). The food habit of the patient’s shows that their preferred food is sour (16.26%), sweet (31.87%), spiced (23.58%), meat (47.97%) and soft drinks (30.41%). Among the patients, 31.06% are addicted to narcotics and 38.04% are smokers. It is alarming that about 35.77% of the patients are taking this type of drug without the concern of physician which might cause serious adverse effects. It also found that there is...
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Posted by admin on Dec 31, 2017 in |
Synthesis and characterization of Co(II), Ni(II), Cu(II) and Pd(II) complexes of ligand N‘-[(2Z,3E)-3-(hydroxyimino) butan-2-ylidene] benzohydrazide are reported. The ligand is monobasic and bidentate in nature. The molar conductivities reveal that all the metal complexes are non-electrolyte. The metal complexes have been characterized on the basis of spectral and magnetic studies. Co(II) ion forms brown complex Co(BBH)2 which has low spin square planar geometry. The diamagnetic nature and the spectral features of the brown Ni(BBH)2 complex suggests the square planar environment for the Ni(II) ion. Ni(BBH)2 adds on two molecules of pyridine to form a high spin six coordinate adduct. The room temperature magnetic susceptibility measurements of the pyridine adduct of Ni(BBH)2 indicates octahedral nature of the complex which is further supported by the absorption spectrum. The magnetic data in case of Cu(BBH)2 indicates presence of one unpaired electron in Cu(II) ion. The EPR spectrum of Cu(BBH)2 suggests the square planar geometry which is further supported by electronic absorption spectrum of the complex. Studies reveal square planar geometry for Pd(BBH)2...
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Posted by admin on Dec 31, 2017 in |
Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Ofloxacin is an antibacterial fluoroquinolone, widely prescribed in gastric and duodenal ulcers. It exhibits pH dependent solubility, more soluble in acidic pH and slightly soluble in neutral or alkaline pH. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Ofloxacin could be achieved for increasing local action in the gastric region against Helicobacter pylori, with the development of rice bran oil entrapped zinc pectinate beads containing Ofloxacin. Various formulations of floating beads of Ofloxacin were developed using polymers like Low Methoxy Pectin alone and in combination with rate controlling polymers such as Gellan Gum, Karaya Gum and Xanthan Gum. The beads...
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Posted by admin on Dec 31, 2017 in |
Chitosan is a natural biopolymer that has been extensively used traditionally for the treatment of various ailments and as an efficient vehicle or carrier for fabrication, encapsulation and target-specific delivery of a wide range of pharmacological moieties for improved therapeutic efficacy. Despite of numerous characteristic features, the pharmaceutical significance of chitosan is limited due to its poor water solubility. The present study was aimed to investigate the impact of enzyme (hemicellulase)-mediated hydrolysis on the physicochemical characteristics including solubility, physicochemical nature, crystallinity, contact angle/wettability and surface morphology of the WSC. The sustainability of enzymatic method was evaluated by testing aqueous solubility and carrying out fourier-transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), thermogravimetric analysis (TGA), contact angle measurement and scanning electron microscopic (SEM) analysis. Results of solubility studies revealed that hemicellulase-mediated hydrolysis significantly enhanced the aqueous solubility and wettability of the chitosan and exhibited smaller contact angle (θ) in comparison to the unmodified LMWCS. FTIR analysis showed that WSC synthesised via enzymatic hydrolysis exhibited ultra-low molecular weight and increased deacetylation degree...
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Posted by admin on Dec 31, 2017 in |
This study was carried out to isolate and characterize the bio active constituent from Euphorbia heterophylla and also to evaluate anticancer activity for the isolated compound against Breast cancer cell line (MCF -7 Cell line). The isolation of compound was performed on ethanol extract by using column chromatography and ultra sonicator by gradient elution. The structure of isolated compound was established on the basis of chemical test, thin layer chromatography and spectroscopic evidences. (IR, 1H NMR, 13C NMR, Liquid chromatography / tandem mass spectrometry (LC/MS/MS identification with data base library search). The yellow colour compound shows positive test for flavonoids in Thin layer Chromatography for flavonoids in the solvent system n-butanol: acetic acid: water (2:2:6) with Rf value 0.7. From the use of LCMS spectral library search system and TLC it is confirmed that the isolated compound is found to be quercetin. The Docking study was performed for the isolated quercetin against 5, 10 methenyltetrahydrofolate synthetase (MTHFS). The inhibition of (MTHFS) in human MCF 7 breast cancer cells has...
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