Posted by admin on Dec 31, 2017 in |
Aim of the study: This study evaluates the analgesic, anti-inflammatory and antipyretic activities of the aqueous, methanol and n-hexane extracts of Trichosanthes dioica Roxb. to provide experimental evidence for its traditional use such as fever, pain and inflammation. Materials and methods: Investigations on the analgesic effects of Trichosanthes dioica Roxb. was carried out by acetic acid-induced writhing using Aspirin as standard. The anti-inflammatory activity was observed by carrageenin-induced edema of the hind paw of rats using indomethacin as standard. The antipyretic activity was observed by yeast induced pyrexia in rat using Paracetamol as standard. Results: It has been shown that the methanol and aqueous extracts significantly reduced acetic acid-induced writhing response in mice. The methanol and aqueous extracts remarkably inhibited the increase in vascular permeability induced by acetic acid and also significantly decreased the carrageenin-induced rat paw edema perimeter. The methanol and aqueous extracts also shows reduction of body temperature in yeast induced pyrexia in rat model. Conclusion: The results show that the methanol and aqueous extracts have analgesic...
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Posted by admin on Dec 31, 2017 in |
Phenolic extracts of crude oil and methanol extracts of defatted seed cake were used to evaluate total phenolics, flavonoids content and antioxidant activity for two locations. The seeds were evaluated for their proximate composition while oils were subjected to chemical analysis. Salvadora persica had highest phenolics ranged from 12.3 ± 0.3 to 22.3 ± 0.3mg GAE/g and flavonoids content 3.7 ± 0.6 to 6.2 ± 0.2mg CAE/g. The antioxidant activity having IC50 value ranged from 0.024 ± 0.0 to 0.045mg/ml. The highest oil content as 42.5 ± 0.4% and highest protein content was 23.3 ± 0.3%. The oil content of the seeds recorded the highest iodine value 112.0 ± 0.8g/100g. The seeds were found to be rich in Ca, K, Na and P. The dominant fatty acids found in the oils were myristic and palmitic...
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Posted by admin on Dec 31, 2017 in |
This study was conducted to evaluate the antimicrobial and cellular metabolic inhibitory properties of the ethanolic extract from the bark of ‘Lunas-bagon’, Lunasia sp. Extracts were evaluated using the agar well diffusion method for antimicrobial assay. The standard phytochemical screening was done for the determination of compounds that can be considered toxic and MTT assay for the effects of the extract on cellular metabolism. Results showed that the extracts have ability to inhibit selected Gram-positive and Gram-negative bacterial isolates indicating that the extracts are effective antibacterials. Results from the MTT assay revealed at doses lower than 100.0 ug/ml, extracts will not inhibit cellular metabolism of the splenocytes. Higher dose, however shows reduction of metabolic activity which may indicate the onset of apoptosis in cells. Basic biochemical tests indicated the absence of cyanogenic glycosides and anthraquinones, thus the extracts may not have toxic effects. Identification of bioactive compounds in through GC-MS analysis showed the presence of compounds that are known as antimicrobials and also effective in the treatment of selected...
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Posted by admin on Dec 31, 2017 in |
Rheumatoid Arthritis (RA) is a auto-immune disease in which body mistakenly considers some parts of its own system as pathogens and attacks them. RA is a chronic systemic inflammatory illness with prevalence of approximately 0.75% in India. It leads to irreversible joint damage and systemic complications. It is associated with substantial morbidity and increased mortality Better understanding of its pathophysiology has led to the progress of besieged therapies that have significantly enhanced outcomes. The key to beneficial achievement lies in identifying those who will have rigorous critical disease as early as possible, so that efficient management can be initiated prior to unalterable injure occurs. The primary aim of this study is to find out what factors play a significant role in determine the disease. From the brief account of discussion on observation and results of multivariate techniques are established, such techniques are important for they make it possible to encompass all the data from an investigation in one analysis. They in fact result in a clearer and better account...
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Posted by admin on Dec 31, 2017 in |
Doxofylline [7-(1,3-Dioxolan-2-ylmethyl) – 1,3-dimethyl purine-2,6-dione] is a Xanthine derivative drug used in the treatment of Asthma. The molecular formula is C11H14N4O4. Doxofylline is presently available in tablet form with high oral dosages of 400 mg, 800 mg and 1200 mg, Syrup with oral dosage of 100 mg/5mL and Suspension with oral dosage of 100 mg/5mL. It is also marketed as a combination drug with Terbutaline and Montelukast. Extensive literature survey revealed crystals with needle shape morphology. Novel crystal form (Form P) of Doxofylline with new rod shape morphology has been identified and fully characterized by a variety of analytical techniques such as Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimeter (DSC), Thermo Gravimetric Analysis (TGA) and Polarized Microscopy (PM). Since, rod shape crystals are preferable than needle shape crystals for filtrations in pharma manufacturing. The newly prepared novel crystal form (Form P) of Doxofylline with rod shape morphology is more suitable in Doxofylline...
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