Posted by admin on Dec 31, 2017 in |
The present work focuses to check the acute and sub-acute toxicity studies of X42 fraction of Terminalia ivorensis in rats. Materials and methods: The acute toxicity of the extract was evaluated in rats. The rats were administered intraperitoneally the fraction at the dose of 50, 100, 200 and 300 mg/kg bw and recorded general symptoms and mortality. For sub acute toxicity, the rats received intraperitoneally, normal saline (control), 2.5; 5.0 and 10.0 mg/kg of the extract for 28 days. Animals were observed for general behavioral and signs of abnormalities during the experiment duration. The last day, blood was taken for hematological and biochemical analysis. The liver, kidney, and heart tissues were weighed. Results: Acute toxicity study produced dose dependent mortality with median Lethal Dose (LD50) of 200 mg/kg. Repeated administration of fraction caused no mortality. There were no significant changes (p>0.05) observed in serum biochemical markers, hematological markers, body weight changed, relative organs weight when compared to control group. Conclusion: The results show that the extract of T. ivorensis...
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Posted by admin on Dec 31, 2017 in |
Clopidogrel bisulphate is a drug used in inhibiting the platelet aggregation and also used in the treatment of cardiovascular disorders. It acts by inhibiting the adenosine diphosphate and is almost absorbed (98%) after oral administration. Approximately 50 % of drug is excreted in urine and 40% in feces. The plasma half life of drug is about 8 hours which makes frequent dosing necessary to maintain the therapeutic blood levels of drug for a long term treatment. So the transdermal patches were used to deliver the drug directly to systemic circulation through skin. The transdermal patches were prepared by solvent evaporation method. The influence of varying the combination of polymer concentrations at different ratio was evaluated. The polymers used in this study did not alter physicochemical properties of the drug. All the batches were evaluated for physical appearance, thickness, weight variation and drug content uniformity. The in-vitro drug dissolution study was carried out using Franz diffusion apparatus and the release mechanisms were explored. Mean dissolution time is used to characterize...
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Posted by admin on Dec 31, 2017 in |
The aim of present study on Spirulina platensis (Spirulina) was to evaluate the anti-stress activity. The anti-stress activity was assessed by tail suspension method andcold immobilization induced change of biochemical parameters. Acute toxicity (LD50) of Spirulina platensis values was also studied. Duration of immobilization time and cold immobilization induced alteration of biochemical parameters (liver functioning profiles like- AST, ALT, ALP and liver tissue anti-oxidant profiles like- MDA, SOD, GST) were used as a stress indicator. Spirulina platensis administered orally at two different doses of 200 and 400 mg/kg respectively. Diazepam, a well-known anti- stress drug (2 mg/kg i.p.) was taken as standard drug. The dose of 200 and 400 mg/kg of Spirulina Platensis significantly decreased the duration of immobilization time and also provide protection against stress induced alteration of biochemical parameters. It is concluded that the 200 and 400 mg/kg dose of Spirulina platensis have anti-stress...
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Posted by admin on Dec 31, 2017 in |
The study was conducted to study biochemical parameters in 42 major depressive disorder (MDD) patients, 22 males and 20 females (age range 18 – 55 years) visiting the Psychiatric Department, Government Medical College, Jammu. The smoking and alcohol intake was much lower (95.24% and 88.09%) in patients (both male and female) diagnosed with MDD. The well being status is also 76.19% satisfactory with 71.43% patients with no family history of psychiatry illness and 73.81% with absence of chronic morbidity. The levels of thyroid stimulating hormone (TSH), ferritin and insulin are in normal reference range while the Vitamin B and Vitamin D 25OH levels are observed to be lower in 54.76% patients. The present study concluded that there is need for awareness towards these biomarkers as they play an important role in brain functioning by planning awareness programs. Therefore, further study with large sample size to evaluate these biochemical parameters and other risk factors is required to mitigate the effect of depression in the population of...
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Posted by admin on Dec 31, 2017 in |
4-Aryl-hexahydroquinolines in vitro antioxidant properties were evaluated by spectrophotometric method. This method is based on the charge transfer complex which is formed between 4-aryl-hexahydroquinolines and chloranil. AM1 and PM3 semi empirical methods were used to estimate different physicochemical parameters. The antioxidant activity was correlated with these physicochemical parameters and different QSAR models were generated. Docking studies were also performed in the active site of prenyl transferase to identify the structural features of the antioxidants. Docking scores with appreciable binding energy values also exactly correlated with the experimental activity. The chemscore estimated by Gold Software was found to have a good correlation with the experimental activity. The Docking and QSAR results reveal that the electron donating substituents on benzene ring were responsible to improve the antioxidant activity of the...
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