Posted by admin on Dec 31, 2017 in |
Cisplatin is a cytotoxic drug which induced the hepatotoxicity in the albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of cisplatin raised the level of LFT’s enzymes and also reduced the level of antioxidant enzymes in the liver of the mice. Administration of Cuminum cyminum and Nigella sativa extract and silymarin remarkably showed the hepatoprotective effect in the albino mice. Administration of C. cyminum, N. sativa and silymarin decreased the level of ALT, AST, and ALP along with increasing the level of total protein content. It also increased the level of antioxidant enzymes in the liver of albino mice showing its hepatoprotective activity. We found N. sativa has a better hepatoprotective and antioxidant effect than C....
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Posted by admin on Dec 31, 2017 in |
A sensitive, precise and accurate reverse phase high performance liquid chromatographic method (RP-HPLC) using an isocratic elution of 0.1 M NaH2PO4 (pH 3.0) and acetonitrile (80:20 v/v) with a flow rate of 1.0 mL/min, a column temperature of 30 °C and UV detection at 254 nm was developed for the estimation of metformin and benfotiamine simultaneously. The method was validated following guidelines given by International Conference Harmonization. The method allowed the determination of metformin and benfotiamine in the concentration range of 100-300 μg/mL and 15-45 μg/mL, respectively. The limit of detection & limit of quantification were 0.290 μg/mL & 0.968 μg/mL for metformin and 0.047 μg/mL & 0.156 μg/mL for benfotiamine, respectively. The percent relative standard deviation (%RSD) value was 0.067 % for metformin and 0.047 % for benfotiamine. The accuracies were 99.510 – 99.797% and 9.652 – 99.890% for metformin and benfotiamine, respectively. The developed and validated RP-HPLC method was applied successfully for the quantification of metformin and benfotiamine simultaneously in tablet dosage form. Common excipients in the...
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Posted by admin on Dec 31, 2017 in |
Morinda citrifolia L. (Rubeaceae) is a medicinal plant commonly called as Noni. Traditionally the entire plant is used for the treatment of cancer, inflammation, hypertension, diabetes, bacterial infections, and arthritis. The present study aims to explore the antineoplastic activity of Noni Juice (NJ) and Divine Noni Gold (DNG) concentrate on Ehrlich ascites carcinoma (EAC) bearing mice. Antineoplastic activity of NJ and DNG was evaluated in EAC bearing mice by administrating 0.35 ml/mouse p.o. respectively once daily for 14 days, before half an hour of NJ and DNG administration animal received single dose of cisplatin (CP) at the dose of 5.0 mg/kg b.w. i.p. on day 1 in respective cluster. Antitumor activity of NJ and DNG were measured by evaluating Mean Survival Time (MST), percentage Increase in Life Span (%ILS), body weight, tumor volume and viable cell count, additionally biochemical markers as well as hematological parameters were also evaluated. In the result, observed NJ and DNG respectively showed significant decrease tumor volume, viable cell count, body weight and raised MST...
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Posted by admin on Dec 31, 2017 in |
To evaluate a meticulous pharmacognostic cram of Cayratia pedata (Lam.) Gagnep. var. glabra Gamble (Vitaceae), an important endemic and endangered medicinal plant in Thiashola, Manjoor. The study genus is used in the Siddha, Ayurveda and Folk medicine for treating diarrhoea, refrigerant, hysteria, astringent and ulcers. However, the detailed scientific information of Cayratia pedata var. glabra is not available to identify the plant material and to ascertain its quality and purity. The plant C. pedata var. glabra is an herbaceous, large, fragile climber grows up to a height of 8-12 m with nodes and internodes. In present communication, morphology, anatomical and physico-chemical characters along with phytochemical screening and fluorescence analysis of powdered crude drug were carried out for systemic identification and authentication of aerial plant parts. This study provides referential information for identification and characterization of C. pedata var. glabra and its...
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Posted by admin on Dec 31, 2017 in |
The present study was designed to investigate the hypolipidemic activity of the methanolic leaf extract of Lagerstroemia speciosa Linn. Plant extract was tested in fat diet induced hyperlipidemic rat models. Methanolic extracts of leaves of Lagerstroemia speciosa Linn. were administered in doses of 250mg/kg and 500mg/kg/day for one week. The obtained results reveal that methanolic leaf extract (LMLS & HMLS) of Lagerstroemia speciosa Linn. showed significant antihyperlipidemic...
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