Posted by admin on Feb 28, 2018 in |
Benzimidazole is a heterocyclic aromatic organic compound which has been an important pharmacophore and privileged structure in medicinal chemistry. Substituted benzimidazoles have considerable interest as compounds with a wide spectrum of biological activity and low toxicity. In the present study, a new series of benzimidazole thiourea derivatives are synthesize and screened for antibacterial and antifungal activity. The Methyl 4-(1H-benzo[d]imidazol-2-yl) phenyl carbamodithioate amine derived from Methyl 4-(1H-benzo[d]imidazol-2-yl) phenyl carbamodithioate (TD1-TD6) have been synthesized by reacting the thio methyl group with different amines in presence of ethanol. The synthesized compounds were characterized by FT-IR, 1H NMR, Mass spectra and elemental analysis. The synthesized compounds were screened for their in vitro growth inhibiting activity against four bacterial strains Bacillus subtilis, Staphylococcus aureus (Gram positive bacteria); Escherichia coli, Pseudomonas aureginosa (Gram negative bacteria) and two fungal strains namely Candida albicans and Asperginous niger. The synthesize compounds were compared with standard agents norfloxacin for antibacterial and fluconazole for antifungal activity using well plate method. Compounds exhibit good activity in bacteria Bacillus subtilis and fungous...
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Posted by admin on Feb 28, 2018 in |
An ethanolic extract of Kariyat (Andrographis paniculata) was prepared by using Soxhlet extractor. Kariyat ethanolic extract (KEE) was subjected for phytochemical investigations and screened for analgesic and antipyretic activities in experimental animals. High performance thin layer chromatography (HPTLC) and gas chromatography mass spectrometry (GC-MS) investigations indicated presence of steroids, phenols, terpenoids, alkaloids, saponins, flavonoids etc. The various concentrations ethanolic extract were tested for analgesic activity in mice by using acetic acid-induced writhing in mice and hot-plate method. The maximum protection of 56.23 % against writhing movement was observed at 300mg/kg when compared to standard drug which showed 79.43% protection. Analgesic activity of KEE using hot plate method indicates mean basal reaction time increased significantly in the treated group compared to control group from 30 min onwards. The various concentrations of KEE also tested for antipyretic activity in rats by using Brewer’s Yeast Induced Hyperpyrexia and results significant antipyretic activity 1 hr after drug administration. Mechanism of action was determined by studying prostaglandin inhibition studies. Results indicated that KEE produces...
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Posted by admin on Feb 28, 2018 in |
The objective of present study was formulation and evaluation of fast release tablets of Fexofenadine hydrochloride. Fexofenadine hydrochloride is an anti-histamine with selective H1-receptor antagonist activity. In this investigation fast release tablets of Fexofenadine hydrochloride were prepared using cross povidone as a superdisintegrants by melt technology method. The Fourier transform infrared spectroscopy revealed absence of any drug – excipient interactions. The tablets were evaluated for pre-compressed evaluation like bulk density, tapped density, Hauser’s ratio, Carr’s index and angle of repose and post-compressed evaluation like weight variation, thickness, hardness, friability, wetting time, disintegration time, content uniformity and in-vitro drug release profile. The wetting time for all batches was found in the range of 20.1 to 80.1 sec. All the tablets were disintegrated within 100 seconds. In-vitro percent drug release was found up to 98.25 % in 30 min. The formulation 4 showed better result in wetting time, disintegration time and drug release...
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Posted by admin on Feb 28, 2018 in |
Sorghum is an important food source with substantial nutritional value. An in vitro antioxidant evaluation of different extractions of graniferous sorghum [Sorghum bicolor (L.) Moench] hybrid Guanipa 71 was proposed here. Acetone / water extracts of both grains and brans revealed strong antioxidant properties by reducing Fe3+ (22.9% and 42.3%) and chelating Fe2+ (47.3% and 32.4%), respectively. Moreover, both extracts were found to inhibit the DPPH● radical, exhibiting an IC50 (μg/mL) of 31.34 and 36.48 respectively, as well as, to reduce Molybdate (VI) through the relative antioxidant capacity assay (IC50 of 330and 227.6μg/mL, respectively). They also inhibited the oxidative degradation of 2-deoxyribose (2-DR) provoked by the Fenton reaction by 29.60% and 17.77%, respectively. Furthermore, aqueous extracts of grains and brans chelated Fe+2 by 65.09% and 59.12% and inhibited the degradation of (2-DR) in the Fenton reaction by 17.18% and 10.67%, respectively. Overall, the results showed that the acetone / water extraction from the brans of sorghum showed the best antioxidant effects, via electron transfer, radical scavenging and metal chelating...
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Posted by admin on Feb 28, 2018 in |
Let G(V,E) be a simple connected graph. For an edge e=uv, mu(e) is the number of edges lying closer to the vertex u than v, analogously define mv(e). The edge version of PI index of a graph G is defined as .Nano-structured TiO2 has been widely used in various applications such as biosensors, solar cells and biomaterials. Synthesis of nano-structured Titanium dioxide (TiO2) such as Nanotubes, Nano-wires and nano-fibers has raised interest lately due to their high surface to volume ratio and the ability of provoke a greater degree of biological plasticity compared to conventional microstructures. Nano-structured TiO2, has been widely used in various applications such as biosensors, solar cells, photocatalysis, phoelectrolysis and biomaterials. In this paper, we compute the edge-PI index of Titania Nanotubes...
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