Posted by admin on Jan 31, 2018 in |
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), substituted aromatic aldehyde 4(a-b), and thioglycolic acid mixed in ethanol. After completion of the reaction products obtained 6(a-f) was confirmed by spectroscopy. Library of such [1, 3, 4] thiadiazin-2-ylamine and [1, 3, 4] thiadiazin-2-yl)-thiazolidin-4-one derivatives has been generated and the structures were subjected to PASS for their probabilities of being biologically active. Biological prediction study of the library was done to find out most active molecules. Computer programme PASS predicted for three activities with top probability for compound 3(a-c) as- 1. Mucomembranous protector, 2. Arylacetonitrilase inhibitor, 3. Macrophage elastase inhibitor. Similarly Compounds 6(a-f) were predicted for two activities with top probability as- 1. CC chemokine-4-receptor antagonist, 2. Phosphatase...
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Posted by admin on Jan 31, 2018 in |
This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE), epileptic group pretreated with aqueous (AE) extract and epileptic group pretreated with diazepam (DP; Reference control) (2 mg/kg b.w/ip/ day). The CA extract is administered at the dose of 200 mg/kg body weight orally for one week. The experimental results were observed that the decreased content of phospholipids in the entire brain regions i.e. Cerebral cortex (CC), Cerebellum (CB), Hippocampus (HC) and Pons medulla (PM); total cholesterol, triglycerides and increased content of Lipid peroxidation in epileptic rats. The reversal changes were observed on pre treatment with the chloroform extract of CA and diazepam. Hence, it is evident that the different bioactive factors of CA offered protection against PTZ-induced...
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Posted by admin on Jan 31, 2018 in |
Objectives: To compare the efficacy, safety and cost effectiveness between oral Balofloxacin and oral Levofloxacin in acute uncomplicated urinary tract infections. Methods: Total 130 patients were enrolled for the study, out of them 119 patients completed the study. Patients were divided into two groups randomly; 63 patients received Balofloxacin 100 mg BID orally and 56 patients received Levofloxacin 500 mg orally OD for 5 days. Baseline evaluation of clinical features and urine culture was performed for isolation of causative organism. After 5 days on completion of therapy above parameters were repeated and compared. Analysis of reported adverse drug reactions (ADRs) and cost effectiveness was carried out. Results: After completion of treatment clinical evaluation showed Cure rate was 82.54% and 85.71%, while Effective rate was 96.83% and 98.21% for Balofloxacin and Levofloxacin group patients respectively. Bacteriological evaluation revealed that bacteriological clearance rate for Balofloxacin and Levofloxacin was 94.91% and 98.11% respectively. There was no statistical difference between both drugs for clinical and bacteriological cure (p > 0.05). ADRs reported were...
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Posted by admin on Jan 31, 2018 in |
India is the largest producer of the medicinal plants and is rightly called the “Botanical Garden of the world”. The objective of the present study is to evaluate the hepatoprotective activity of aqueous extract of Inflorescence (IA) and Pollen grains (PA) of Casuarina equisetifolia belongs to the family of Casuarinaceae against Paracetamol induced hepatotoxicity in Wistar rats. The aqueous extract of Casuarina equisetifolia IA and PA (250mg/kg and 500mg/kg. p.o.), were administered respectively to the animals. The drug Paracetamol (2g/kg. p.o.) was used to induce the hepatotoxicity and the drug Silymarin (25mg/kg. p.o.) was given as the reference standard. The plant extract was effective in protecting the liver against the hepatotoxicity induced by the Paracetamol in rats. This was evident from the significant reduction in serum enzymes like Serum glutamic pyruvic transaminase (SGPT), Serum glutamic oxaloacetic transaminase (SGOT), alkaline phosphatase (ALP) and total bilirubin (TB) levels. It was concluded from the result that the aqueous extract of Casuarina equisetifolia IA and PA possesses good hepatoprotective activity against Paracetamol induced...
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Posted by admin on Jan 31, 2018 in |
T-cell activation, with the low expression of CD62L (L-selectin) marker in the spleen, will increase B cell activity to produce lupus antibodies. Therefore, lupus patients need drugs which could increase the L- selectin expression in the spleen to reduce the auto-reactive T cell. The tested drug to increase the L-selectin in this research was the ethyl acetate fraction of Kalanchoe pinnata (Lmk) Pers leaves (EF-KP), based on its immunosuppressant and anti-inflammatory activities. The research was performed by means of 2, 6, 10, 14 tetramethylpentadecane (TMPD) induced lupus-like mice. The experimental groups consisted of negative control (NC), EF-KP, and positive control (PC) groups. After 21 day treatment, the blood leukocyte was checked. Then, the spleen was prepared for the flow cytometry method to measure CD4+CD62L+ and CD8+CD62L+ T cells. The relative percentage of CD4+CD62L+ T cells in EF-KP groups increased insignificantly (p>0.05) (NC=7.91 ± 4.98%, EF-KP = 8.63 ± 3.07%, PC = 12.62 ± 8.09%). The relative percentage of CD8+CD62L+ T cells increased significantly (p < 0.05) (NC = 6.20...
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