Posted by admin on Nov 30, 2017 in |
The objectives of the present study were to evaluate the preliminary phytochemical analysis (quantitative and qualitative) and DPPH antioxidant activity of two traditionally important plants occurring at Purulia district of West Bengal in India. Qualitative analysis of phytochemicals (flavonoid, alkaloid, terpenoids, saponins, phenol and carbohydrate) and quantitative analysis of total phenolics and flavonoids were done by using suitable test protocols available in the literature. Antioxidant activity was studied through DPPH assay. Qualitative phytotochemical analysis revealed that the methanolic extract exhibit richness in flavonoids, alkaloids, terpenoids, saponins, phenols and carbohydrates in comparison with aqueous extract. Total phenol and flavonoid content shows highest concentration in methanolic part of A. aspera (1.129mg GA EQ/gm, 3.22mg QEQ/gm) and lowest concentration in aqueous part of S cordifolia (.348mg GA EQ/gm, .324mg QEQ/gm). EC50 values of the two plants were 48.06µg/ml in A. aspera and 52.43µg/ml in S. cordifolia. The results conclude that there is positive correlation between total phenol content and DPPH antioxidant activity. The plants could serve as potential source of natural...
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Posted by admin on Nov 30, 2017 in |
Plants possess good antioxidant capacity to get rid of free radicals that cause many lifestyle diseases especially cancer. Assessment of Antioxidant activity of Amaranthus Linn. leaves were evaluated by using in- vitro model. In the present study evaluation of ethyl acetate of extract of Amaranthus Linn. leaves with the help of two In-vitro antioxidant models were carried out for Nitric-oxide scavenging Activity and DPPH method. IC50 value was calculated and compared with standard Ascorbic acid. Ethyl acetate extract was found to be extremely effective in scavenging nitric-oxide (IC50 584.4 μg/ml to 1072 μg/ml). In inhibition of DPPH Radical Scavenging activity (IC50 260.6 μg/ml to 957 μg/ml). Ethyl acetate extract showed different levels of antioxidant activities in tested...
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Posted by admin on Nov 30, 2017 in |
The alcoholic extract of fruits of the plant Luffa acutangula previously reported for is hepatoprotective activity was fractionated into three parts to chemically identify the most potent bioactive fraction. The hepatoprotective potential of the fraction prepared from extract was studied in vivo in rats as well as ex vivo in isolated hepatocytes against paracetamol induced hepatotoxicity. The hepatoprotective activity was determined on the basis of their effects on parameters like direct bilirubin, serum aspartate transaminase, serum alanine transaminase and alakaline phasphatase. Ethyl acetate fraction (EAF) of alcoholic extract 100 mg/kg, p.o.) exhibited maximum hepatoprotective activity and is the active fraction for hepatoprotective activity of L. acutangula...
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Posted by admin on Nov 30, 2017 in |
Cinnamomum riparium Gamble belongs to the family Lauraceae is a red listed species by the International Union for Conservation of Nature (IUCN). It is a tree growing in evergreen forests and traditionally used for treating conditions like wound healing, fever, intestinal worms, headache, inflammations, menstrual problems etc. According to tribal’s, this activity is mainly due to the volatile oil present in it. But as per published reports much works have not been carried out so far using its volatile oil. Hence it was thought worth to do the research work on this plant. Berries were collected from Paniyeli poru, near Periyar river, Ernakulam District, latitude 10.1720° N and longitude76.5959° E Kerala, India. Berry essential oil was separated by steam distillation technique by using a Clevenger trap apparatus. Separated berry essential oil was used for evaluating the physical and chemical properties including therapeutic activity (antioxidant activity) using DPPH scavenging assays. The berry oil exhibited 76.45% of antioxidant activity. The oil was subjected to GC-MS analysis. The main constituents present in...
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Posted by admin on Nov 30, 2017 in |
Diclofenac sodium is a nonsteroidal anti-inflammatory drug (NSAIDs) with analgesic and antipyretic properties. Because of widespread use of this drug, quality control testing should be done for diclofenac marketed products to ensure safety; efficacy; accepted quality; rationality of use to protect public health. Quality of pharmaceuticals has been great concern of WHO. Drug cost needs to be reduced as health care costs continue to rise. Generic products need to be therapeutically equivalent to the brand innovator products. This can be achieved only when bioequivalent study is conducted to show whether a generic product is interchangeable with brand product or another generic product. In this study focus is given to evaluate and compare the quality of six different brands of enteric coated diclofenac sodium tablets marketed in Addis Ababa and also to study the different physicochemical properties of diclofenac sodium enteric coated tablets and to compare in vitro dissolution profile of six brands of diclofenac sodium delayed release...
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