Posted by admin on Feb 19, 2018 in |
The aim of study is to develop microsponge based delayed release dosage form, technique used to manufacture microsponge was quasi emulsion diffusion technique. Eudragit L 100 and Eudragit S 100 polymer is used to incorporate lansoprazole in microsponge. Lansoprazole is acid labile drug hence release of lansoprazole was delayed from acid environment. Microsponge contains porous polymeric microspheres, typically 100 – 250 μm in diameter. Compatibility of the drug with adjuncts was studied by DSC. Production yield, loading efficiency, particle size analysis, surface morphology and in-vitro release studies were carried out. Optimized microsponge blended with other diluents and filled in capsules. Blend containing lansoprazole Microsponge were evaluated for SeDeM parameters to check its flow. The microsponge formulation F2 showed delayed release of lansoprazole in buffer stage pH 6.8 bypassing the acidic stage. The result reveals that developed microsponge are cost effective and can be used as a delivery system for acid labile drug lansoprazole to avoid its degradation in acidic media of the stomach. SeDeM technique can be employed for...
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Posted by admin on Feb 11, 2018 in |
Background: Advancement in pharmacotherapy leading the new drug discovery for the clinical problem, as well as it’s also exploring the clinical applications and Drug-Related Problem (DRP). DRP is an event or circumstances, which involving drug treatment that interfere or potentially interferes with patient achieving an optimum outcome of medical care. DRP cause significant morbidity and mortality in health care. Method: A prospective, observational study conducted was performed on 120 patients. Patient age more than 18 years of either gender and diagnosed with the psychiatry disorder were enrolled in the study. Result: Total 120 patients were enrolled and five type of DRPs were obtained during the study, ADR 24 (44.4%), drug-drug interaction 6 (11.1%), overdose 12 (22.2%), sub-therapeutic dose 6 (11.1%), failure to receive drug 6 (11.1%). Out of 103 Interventions, 54 (52.4%) suggested recommendation were accepted by the psychiatrists. Conclusion: The overall study suggested that the clinical pharmacist has a huge scope and it is an integral part of the health care team. The clinical pharmacist has greater responsibility...
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Posted by admin on Feb 9, 2018 in |
DNA barcoding is currently gaining popularity due to its simplicity and high accuracy as compared to the complexity and subjective biases associated with morphology-based identification of taxa. The standard chloroplast DNA barcode for land plants is normally recommended by the Consortium for the Barcode of Life (CBOL) plant working group that needs to be evaluated for a wide range of plant species. In Visakhapatnam district of Andhra Pradesh state, there are many natural and manmade seasonal wetlands that serve as important gateways for the migratory waterfowl. Hence these wetlands contribute significantly towards balancing of ecosystem. Many researchers had identified plant species of these wetlands by traditional methods but the aspect of identification of plants through barcoding has largely been ignored. We therefore, tested the potential of the rbcL marker for the identification of Mangrove plants belonging to two families of some wetlands of Visakhapatnam. This had been carried out by rbcL gene as the standard plant barcode Maximum likelihood tree analysis was also performed to evaluate the discriminatory power...
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Posted by admin on Feb 6, 2018 in |
A simple and fast isocratic reverse phase- high performance liquid chromatography (RP-HPLC) method was developed for estimation of iloperidone from rat plasma employing a photo diode array (PDA) detector. The plasma samples were prepared by protein precipitation using acetonitrile as extracting solvent. The chromatographic separation was performed on a BDS Hypersil Phenyl column (250 mm × 4.6 mm; 5 μm) using a mixture of 0.01 M sodium dihydrogen phosphate buffer (pH 6.0) and acetonitrile (60:40, v/v) as mobile phase with a flow rate of 1.5 ml/min, retention time 7.04 min, and detection wavelength 276 nm. The method was validated for linearity, sensitivity, selectivity, accuracy, precision, and stability according to USFDA guidelines. The calibration curve exhibited linearity in the concentration range of 50–1000 ng/ml (r2=0.998) and the lower limit of quantification (LLOQ) and limit of detection (LOD) of the method were 50 ng/ml and 30 ng/ml respectively. The chromatographic runs were selective without any interfering peaks at the retention time of iloperidone. The accuracy and precision of the method were within USFDA specified range. The plasma samples...
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Posted by admin on Jan 31, 2018 in |
The World Health Organization 2015 (WHO) reports indicate that there were 9.0 million new tuberculosis (TB) cases and 1.5 million tuberculosis (TB) deaths during 2015. Co-infection with the HIV fuels the global TB crisis, and successful TB treatment is further complicated and hampered by the existence of multidrug- resistant (MDR) TB and extensively drug resistant (XDR) TB. Hence there is an urgent need for newer anti tubercular agents. Heterocyclic moieties possess profound biological activities including anti inflammatory, antitumour, antitubercular activity. The Benzothiazole nucleous and the thiophene nucleous exhibit profound pharmacological activity and so series of 2-amino thiophene derivatives were designed and docked against the enzyme glutamine synthetase-1 (PDB-ID- 4ACF) which plays an important role in the metabolism of nitrogen. Similarly, a series of Schiff bases with benzothiazole scaffolds were designed and docked against cyclopropanemycolic acid synthase-2 (PDB-ID-1KPI), the enzyme specific for synthesis of cell wall of Mycobacterium tuberculosis. Based on the docking score, interactions and docking pose molecules were screened and the selected compounds were synthesized. The synthesized compounds...
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