Posted by admin on Jan 31, 2018 in |
Curcuma longa nano powder was prepared by high energy ball milling equipment using green synthesis. Green synthesis is the process of synthesizing nanoparticle from biogenic resources based on the fact of its bioactive potential would be less toxic (product & bi-product), environmental safety (eco-friendly and biodegradable) cost effective and easily available to its natural origin. The powder was characterized by X-ray diffractometer (XRD), Scanning Electron Microscope (SEM), Fourier Transform Microscope (FTIR) and Photoluminescence spectrometer (PL).XRD and SEM results shows average crystalline size and grain size of turmeric powder are in nanometer range. Types of functional group and bond character in the nano powder were determined using FTIR. Optical properties of curcumin was includes changes the colour from yellow to red and emission of multicolour peak in visible region. In this approach, eco-friendly, rapid ways large amount of nano powder can be produced. Such nanometric food particles can improve the physicochemical properties of food materials. Since this materials also possess luminescence with nano size and hence may be useful in...
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Posted by admin on Jan 31, 2018 in |
Introduction: Patients with chronic kidney disease undergoing hemodialysis are usually co-morbid with hypertension that contributes to increased cardiovascular morbidity and mortality if not controlled. A number of factors are targeted as influencing agents to uncontrolled hypertension but adherence to treatment is counted as a major factor contributing to poor control of hypertension. Methods: A cross-sectional study was conducted at the renal unit amongst a sample size of 144 hypertensive patients aged 18 years and above, respondents were identified using simple random sampling. Data was collected using semi structured questionnaires. Data analysis using Chi square test was applied to establish significant relationships between the dependent variable (adherence) and independent variables (knowledge and perception), logistic regression was used to predict independent variables that influence adherence, and results with p values ≤ 0.05 were considered statistically significant. Adherence was determined using Morisky’s Medication Adherence Scale (MMAS-8). Findings: Overall, 83(57.6%) of the patients were found to have high adherence rate to their antihypertensive medication. Factors that influenced adherence to antihypertensive medication were; age...
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Posted by admin on Jan 31, 2018 in |
Whole body or local irradiation to gut is known to induce significant damage to gut epithelium and crypt stem cells. A large population of microbes in the gut remains unaffected. We hypothesize that the modifications in diet and enteric microbial population may provide a non-toxic mechanism to counter radiation induced health deficit, especially in the gut and therefore investigated the effect of dietary cucurbits in this context. Radio-protective effects of Lagenaria (Ls), Cucurbita (Cp) and Luffa (Lc) were evaluated in mice for cytokines (in jejunum tissues) through ELISA and intestinal villi microscopically. Irradiation of mice increased pro-inflammatory biomarkers NAP-3, IFN-γ and IL-17 and decreased anti-inflammatory biomarkers IL-10, IL-4 and TGF-β. Post-irradiation treatment with cucurbit extract (Ls, Cp or Lc) decreased pro-inflammatory cytokines NAP-3, IFN-γ and IL-17 and increased anti-inflammatory cytokines IL-10, IL-4 and TGF-β in mice. Treatment with cucurbits restored structural integrity of villi in irradiated mice. Various antioxidants and anti-inflammatory molecules present in cucurbits, their positive effects on probiotics and host tissues and microbial fermentation of dietary fibers...
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Posted by admin on Jan 31, 2018 in |
This work involves synthesis of [1, 3, 4] thiadiazin-2-ylamine 3(a-c) derivatives from various substituted acetophenone derivatives 1(a-c), and thiosemicarbazide 2 mixed in ethanol and irradiation with microwaves which were directly used for next step. [1, 3, 4]Thiadiazin-2-yl)-thiazolidin-4-one 6(a-f) were synthesized in the second step from substituted-6H-[1, 3, 4] thiadiazin-2-ylamine 3(a-c), substituted aromatic aldehyde 4(a-b), and thioglycolic acid mixed in ethanol. After completion of the reaction products obtained 6(a-f) was confirmed by spectroscopy. Library of such [1, 3, 4] thiadiazin-2-ylamine and [1, 3, 4] thiadiazin-2-yl)-thiazolidin-4-one derivatives has been generated and the structures were subjected to PASS for their probabilities of being biologically active. Biological prediction study of the library was done to find out most active molecules. Computer programme PASS predicted for three activities with top probability for compound 3(a-c) as- 1. Mucomembranous protector, 2. Arylacetonitrilase inhibitor, 3. Macrophage elastase inhibitor. Similarly Compounds 6(a-f) were predicted for two activities with top probability as- 1. CC chemokine-4-receptor antagonist, 2. Phosphatase...
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Posted by admin on Jan 31, 2018 in |
This study evaluated the anticonvulsant effect of different extracts of Centella asiatica (CA) with particular reference to lipid metabolism in different regions of rat brain. The rats were randomly divided into 4 groups having 6 in each group: i.e. Control group received saline, PTZ-induced epileptic group (60mg/kg b.w op/ 1 day), epileptic group pretreated with chloroform extract (CE), epileptic group pretreated with aqueous (AE) extract and epileptic group pretreated with diazepam (DP; Reference control) (2 mg/kg b.w/ip/ day). The CA extract is administered at the dose of 200 mg/kg body weight orally for one week. The experimental results were observed that the decreased content of phospholipids in the entire brain regions i.e. Cerebral cortex (CC), Cerebellum (CB), Hippocampus (HC) and Pons medulla (PM); total cholesterol, triglycerides and increased content of Lipid peroxidation in epileptic rats. The reversal changes were observed on pre treatment with the chloroform extract of CA and diazepam. Hence, it is evident that the different bioactive factors of CA offered protection against PTZ-induced...
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