Posted by admin on Aug 31, 2017 in |
Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting angiogenesis. In this present study we characterized the physicochemical and functional properties of endoglin gene using bioinformatics tools as this had not been studied previously. The three dimensional structure of endoglin was also computed using homology modelling and the reliability of the model was assessed by predicting its secondary structure along with validation. Additionally, using experimental evidence score, phylogenetic analysis and protein-protein network was framed between endoglin and its interacting neighbouring partners. These results are innovative and relevant enough to start prospective studies that will allow us to establish the relative strength of the prediction of diabetic retinopathy according to the endoglin levels presented...
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Posted by admin on Aug 31, 2017 in |
SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets – control set (1) were kept in control conditions, while, rats of experimental set (2) were exposed to 80 ppm of SO2 gas 1h/d for 30 and 60 days and rats of experimental set (3) were exposed to 80 ppm of SO2 gas 1h/d with oral administration of Emblica officinalis fruits extracts (200 mg/kg b.wt.) for 30 and 60 days, respectively. The results exhibits that rats of 30 days showed non-significant (P > 0.05) decrease in plasma potassium ion concentration compared with the control while the rats of 60 days showed significant (P < 0.05) decrease in plasma potassium ion concentration compared with the control. The SO2 exposed subjects show significant (P < 0.05) decrease in...
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Posted by admin on Aug 31, 2017 in |
Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. All cases pertaining to hyperglycemia were identified from medical record archive of a random sample of patients admitted to KAMC, from January 2015 to December 2015. Patients with a previous history of diabetes were excluded from the study. The case/non-case method was employed to find association between identified drugs and hyperglycemia. The hyperglycemia risk was estimated by calculating the reporting odds ratios (ROR). The results reveal about one fifth of study population was admitted primarily due to hyperglycemia. A significant association for hyperglycemia has been shown with corticosteroids, immunosuppressants and anticholinergic agents with ROR = 2.63; 95% CI (1.26-5.51), ROR = 8.38; 95% CI (2.33-30.16) and ROR =...
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Posted by admin on Aug 31, 2017 in |
The aim of the study was to prepare Temozolomide loaded solid lipid nanoparticles and evaluating loaded solid lipid nanoparticles. Temozolomide loaded solid lipid nanoparticles were prepared by micro emulsification method using different lipid (stearic acid) concentration keeping drug concentration unchanged, poloxamer 188 and cetyl alcohol as surfactant and co-surfactant. The prepared SLN were characterized for surface morphology by SEM analysis, drug loading and % entrapment efficiency, FTIR, zeta potential and in vitro diffusion studies. The lowest and highest % Entrapment Efficiency was found to be 85.85% and 97.45% for F1 to F5 batches respectively. Release studies were done by using saline phosphate buffer pH 7.4 using dialysis bag diffusion method. Zeta potential was found to be – 20.3 mV and particle size was found to be 119.34. For 8 hrs in vitro drug release found to be 79.16%, 74.45%, 71.42%, 61.36%, and 55.13% respectively. The release data was analysed by different kinetic models and found that the formulations best fit model is peppas and the drug release mechanism was...
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Posted by admin on Aug 31, 2017 in |
Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions having written diagnosis ARI/URTI/common cold were selected for study. Information on demographic profile and treatment were spread over three different age groups (i.e. Neonates: up to one month of age, Infants: 1 month to 1year and Children: 1-14 years). Each prescription then was analyzed as per objectives of study. Results: Male patients were more as compared to females and most of the patients were in the age group of 1-14 years. Antihistaminics were the most frequently prescribed class of drugs (28.52%) followed by antimicrobials (26.35%). Antihistaminics constituted 63.08% of respiratory drugs prescribed. Antimicrobials were prescribed in 86.57% of the prescriptions and Cefpodoxime was the most frequently prescribed antimicrobial agent followed by Amoxicillin-clavulinic acid combination....
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