Posted by admin on Nov 30, 2017 in |
Siddha system of medicine is the ancient traditional medicine practiced all over Tamil Nadu. Siddha system is bestowed with various specialities of few which are Varmam, Pranayamam, Yoga and Kayakarpam. This system has a vast repository of internal and external medicines; Varmam is one among such therapies used to treat multiple ailments, especially related to musculoskeletal and neurological deficits. Varmam is the vital life energy points located in human body and was identified as 108 points by the Siddhars. Here the Varmam treatment for Azhalkeelvaayu (Osteoarthritis), one of the types of Keelvaayu mentioned in the Siddha Noi naadal book is evaluated in a small group of patients. Among the elderly knee Osteoarthritis is leading cause of chronic disability in developed countries. Osteoarthritis (OA) is the second most common rheumatologic problem and is most frequent joint disease with prevalence of 22% to 39% in India. A study was done on 30 clinically diagnosed patients of osteoarthritis (knee joint). Such patients who underwent Varmam therapy are observed and results are presented....
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Posted by admin on Nov 30, 2017 in |
Community pharmacists are well placed to contribute to reduction of premature deaths from cardiovascular disease by implementing risk assessment and reduction strategies. The objective of this study was to assess outcomes of pharmacist’s cardiovascular risk reduction intervention among high risk persons dwelling in a rural community. Cardiovascular risk reduction intervention was carried out among 45 high risk patients using a non-randomized before and after design. Blood pressure, total cholesterol, random blood sugar and BMI were measured. Intervention consisted of leaflet based patient education, referral to physician and provision of prescribed medications at no charge. Data were expressed as mean, standard deviation and 95% confidence interval. Differences between baseline and post intervention values were explored using paired t test. The primary outcome measure was change in cardiovascular risk category between baseline and end of study. The results show that there were significant differences in blood pressures at baseline vs. post-intervention, (184.74 ± 15.78 vs. 138.69 ± 13.57; P ˂ 0.001), and (102.17 ± 15.14 vs. 82.62 ± 9.45, P ˂...
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Posted by admin on Nov 30, 2017 in |
Objective: Newly designed antipsoriatic agents which are substituted series of analogues of flavonoids (kaempferol and quercetin) that belong to the subclass flavonols were subjected to (2D-QSAR) analysis using VLIFEMDS-QSARPro software with an intention to derive and understand the possible correlation of biological activity as dependent variable and other descriptors like molecular weight, XLogP values as independent variables. It can be concluded that the current study provides better insight for designing and chemical synthesis of more potent antipsoriatic agents. Methods: Several statistical regression expressions were obtained using variable selection method as simulated annealing coupled with various model building methods like partial least squares (PLS) Regression, multiple linear regression (MLR) etc. Results: For the analogues of both quercetin and kaempferol, a total of 9 QSAR models were generated, each using test set of 15 and training set of 45 similar compounds. The best QSAR model generated by PLS model building method for quercetin was model Q4 with correlation coefficient r2 of 0.9021 and significant cross validated correlation coefficient q2 of 0.5791.Similarly,...
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Posted by admin on Nov 30, 2017 in |
A simple, precise isocratic stability indicating RP‐HPLC method was developed for the determination of isopropamide and trifluoperazine in pure and its pharmaceutical formulations. In the developed method, methanol, acetonitrile and water in the ratio of 40:30:30 (v/v) as mobile phase and Waters C-18 (250mm x 4.6mm, 5μm) column as stationary phase were used. The flow rate and detection wavelength were 0.9mL/min and 240 nm respectively. The method was validated as per ICH guidelines for specificity, linearity and range, precision, accuracy, robustness, solution stability, limit of quantification and limit of detection. The stability-indicating capability was established by forced degradation experiments. The results of all the validation parameters were well within their acceptance limits and also the degradation products formed during different stress conditions in stability studies were separated from both drugs and also from individual degradation products. This validated method was applied for the simultaneous estimation of isopropamide and trifluoperazine in commercially available formulation...
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Posted by admin on Nov 30, 2017 in |
This work investigates the effects of the surfactant system used and of spray drying temperature in physicochemical properties and retention of bioactive compounds of lipid based systems loaded with bioactive compounds of Syzygium aromaticum. Seven formulations were prepared, containing Compritol 888 ato and buriti oil as lipids and maltodextrin DE10 as wall material. The surfactants Poloxamer 188, Gelucire 50/13 and Gelucire 50/2 were employed and classified by their hydrophilic-lipophilic balance (HLB). The emulsions were homogenized by means of an ultrasonic probe and spray dried. The eugenol and eugenyl acetate content of each formulation was quantified by HPLC before and after the spray drying process. Higher eugenol retention was obtained for the composition using the amphiphilic surfactant Gelucire 50/13® (HLB of 13). Retention of bioactive marker compounds was affected by spray drying temperatures. A higher spray drying temperature (140 °C) increased eugenol loss. The particle morphology was affected by the formulation composition and the drying...
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