Posted by admin on Jul 31, 2017 in |
Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, followed by stem, primarily by aqueous and methanolic extracts. The methanol and ethyl acetate extracts from all four plant parts showed decent antioxidant activities against DPPH free radicals, with methanolic extract of N. arbor-tristis stem showed activity as 86.9%, higher than the positive control. All the ethyl acetate extracts showed moderate to good activity (50-65%), showing that all the four plant parts have decent antioxidant potential. Further, the scavenging of the peroxide free radicals, produced during lipid per oxidation was also investigated. The methanolic extracts of flower and root, and ethyl acetate extract of stem showed almost 80% activity. The aqueous extract of leaf showed very good peroxide scavenging activity. The hexane extract...
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Posted by admin on Jul 31, 2017 in |
The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity....
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Posted by admin on Jul 31, 2017 in |
The lanthanide (III) complexes of general formula of [Ln(FPNH)2(NO3)](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; FPNH = 2-formylpyridine nicotinoylhydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscopy. Molar conductivity data suggest that the complexes are 1:2 electrolytes. IR spectral data suggest that FPNH acts as neutral tridentate ligand. Spectral data of complexes suggest that the ligand binds metal ion through pyridine nitrogen, azomethine-nitrogen and amido-oxygen donor atoms. Electrochemical behaviour of metal complexes was investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one electron reduction. The binding interaction of complexes with CT-DNA was investigated using absorption spectrophotometry. Based on spectral changes, groove binding of complexes to DNA is...
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Posted by admin on Jul 31, 2017 in |
Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (MES) induce...
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Posted by admin on Jul 31, 2017 in |
This study explored self-reported chronic illnesses and use of prescription medicines (PM) by elderly Malays in the community. The study was a population based cross sectional study conducted among 490 Malay subjects aged ≥ 60 years in the semi-urban and rural areas in Perak, Malaysia. The study was conducted using pre-validated questionnaires after getting informed consent from the study participants. Critically ill and subjects with cognitive impairment were excluded from the study. The mean age of the elderly respondents was 69.7 years and 68.4% of the elderly were females. Respondents belonging to the age group 60-69 years constituted the largest group (54.5%). The most common illness reported was hypertension (59.8%) followed by hypercholesterolemia (42.7%) and diabetes mellitus (32.2%). Other chronic illnesses were osteoarthritis (6.3%), bronchial asthma (4.1%), other cardiovascular diseases (2.2%) and other diseases (19.2%). 52.9% of elderly study subjects had multiple illnesses. 76.7% used at least one prescription medication. The highest users of PM were aged between 70-79 years, while the lowest users of PM were ≥ 80...
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