Posted by admin on Sep 30, 2017 in |
We studied the feasibility, safety, clinical benefit, efficacy and 30 day outcome in 50 patients receiving tirofiban in patients with failed thrombolysis in acute ST elevation myocardial infarction, and compared with 50 patients for age, gender and infarct location, who did not receive rescue treatment for different reasons. Tirofiban resulted in an overall ST segment elevation, resolution, at 240 minutes in 44 patients (88 %). Incidence of major events during hospitalization was higher in control group. One patient (2 %) died in study group against 4(8%) in control group while 4 patients had refractory angina needing early percutaneous coronary intervention as compared to 13 in control group. None reinfarcted as against 4 in control group. Two patients developed congestive heart failure against 8 in control group. However, minor bleeding events (mainly gum) were significantly higher, 9 against 0 in control group. Coronary angiography revealed residual thrombus only in 4 patients treated with tirofiban compared to 13 in controls and surprisingly the number of stents required were less in study...
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Posted by admin on Sep 30, 2017 in |
In this study, GC-MS analysis shown that ethyl acetate fraction of Allium cepa (EAFAC) (band one) consists of 55 compounds which shown antileishmanial activity. (IC50 73.1 ± 2.1 ug/ml) is the inhibitory concentration which is observed for ethyl acetate fraction of Allium cepa (EAFAC) (band one). Leishmania major is the specie used for this leishmanicidal assay. In this bioassay, Amphotericin B (IC50 = 0.29 ± 0.05 ug/ml) and pentamidine (IC50 = 5.09 ± 0.09 ug/ml) were used as positive control drugs to compare the parasite inhibition with that ethyl acetate fraction of Allium cepa (EAFAC) (band one). This activity was perceived under incubation period 72 hours and incubation temperature 22 °C. Methanol extract of Allium cepa (MEAC), Hexane fraction of Allium cepa (HFAC), Ether fraction of Allium cepa (EFAC), and Diethyl ether fraction of Allium cepa (DEFAC) and butanol fraction of Allium cepa (BFAC) exhibited no antileishmanial activities. In this research paper we represent 30 compounds out of 55 compounds of ethyl acetate fraction of Allium cepa (EAFAC) (band...
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Posted by admin on Sep 30, 2017 in |
The objective of this study was to design and develop poly herbal cream based formulation using combination of aqueous poly herbal extracts of Rosa damascena flowers (RDW), Clerodendrum paniculatum leaves (CPW), Murraya koengii leaves (MKW) and Annona squamosa leaves (ASW) which increased the collagen content in human dermal fibroblast thereby showing skin anti-ageing property. The presence of collagen –I content in human dermal fibroblast (HDF) cells was confirmed by ELISA. The three different ratios of plant extracts blends (CB 01, CB02 and CB03) were prepared. The extract blend (CB03)in particular ratio (2:2:1:1) of the above individual plant extracts respectively showed 18.65 ± 0.061ng/ml (p < 0.05) of collagen-I as compared to 16.53 ± 0.064 of standard ascorbic acid (ng/ml) at 100µg/ml. Five different carrier cream base was developed (F-1, F-2, F-3, F-4 and F-5. F2 (PHY/AAC/01) formulation was finalised with (CB03) active blend (PHY/AAC/02) which showed 17.53 ± 0.011ng/ml for collagen-I content in HDF cells. The in vitro safety of (CB 03) and (PHY/AAC/02) was measured by neutral red...
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Posted by admin on Sep 30, 2017 in |
The mycological analysis of stored seed of groundnut (Arachis hypogaea) through agar plate as well as blotter paper methods of study revealed presence of 16 fungal species viz., Alternaria alternata, Aspergillus candidus, Aspergillus flavus, A. Niger, A. ochraceous, A. phoenicis, A. tamari, A. terreus, A. sydowi, Fusarium moniliforme, F. oxysporum F. solani, P. glabrum, Rhizopus nigricans, Trichoderma viride and Trichothecium roseum. Out of 20 essential oils extracted from leaf of plants and assessed for their antifungal potential only leaf oil of Tinospora cordifolia,(Willd.) Miers ex Hook. F. & Thoms exhibited absolute toxicity (100%) against dominant fungi Aspergillus flavus, A. niger at 400 ppm concentration. This showed fungicidal activity at 500ppm.It showed MIC against 10 fungi at 400ppm, controlled 15 fungi at 600 ppm. There was no ill effect of physical factors viz., temperature treatment up to 100 °C, autoclaving at 15 lb/square inch pressure at 120 °C and storage up to 105 days on activity of leaf oil. In vivo studies depict that oil of T.cordifolia as seed dressing...
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Posted by admin on Sep 30, 2017 in |
The present study instantiates the phyto-fabrication of silver nanoparticles by utilizing Petrea volubilis L. leaf broth which were instantaneously synthesised, eco-friendly, and cost-effective. The influence of physico-chemical parameters viz. contact time, leaf broth quantity, pH, temperature, and silver nitrate concentration were investigated and optimised to engineer infinitesimal nanoparticles. The SPR bands obtained from UV-vis spectroscopy confirmed the synthesis of silver nanoparticles. The active phytochemicals in Petrea volubilis L. leaf broth namely carboxylic acids, phenolic compounds and aldehydes were found to be responsible for the bio reduction and capping of silver ions according to FT-IR spectroscopy. The capping molecules of NPs were negatively charged and were passably stable as revealed by zeta potential measurements and the XRD patterns illustrated their crystallinity. HRTEM microphotographs enumerate spherical shaped nanoparticles. The EDS analysis at 2θ confirms the synthesis of elemental silver. The nanoparticles were evaluated for their antimicrobial activity. The highest anti-bacterial activity was observed against S. aureus as compared to the bacteria S. typhi and A. flavus a fungus. The leaf extract...
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