Posted by admin on Sep 30, 2017 in |
In this research work, a well established method was used to synthesize of stannane of 2, 4-hexadienoic acid and its characterization was carried using ultraviolet (UV)-visible and 1H NMR (nuclear magnetic resonance). Our research aimed at developing a potent multi-target drug which could act as antibacterial agent and also peroxisome proliferator-activated receptor gamma (PPAR γ) agonists that is having the potential to activate the PPAR γ. In vitro antibacterial study was carried out against, Staphylococcus aureus (gram positive) and Escherichia coli 1610 (gram negative) using ‘well diffusion method’. It was followed by in silico docking studies, using computational software iGemDock v2.1 tool and its effect on glycemic and lipid parameter was also studied. Pharmacokinetic properties were studied using pkCSM software developed by the University of Cambridge. Drug likeness study and all the specifications were tested with the help of Molinspiration Molecule Viewer software available online. It was observed that the stannane of 2, 4-hexadienoic acid inhibited the bacterial growth of Staphylococcus aureus (gram positive) and Escherichia coli 1610 (gram...
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Posted by admin on Sep 30, 2017 in |
In present study total 2352 samples were collected out of that 21.04% were positive for Typhoid fever while 78.95% were negative. The sex wise distribution results showed male are more effected (12.71%) as compare to female (8.33%). However, the age wise distribution showed that 10.45% in 6-10 years, 6.54% in 3-6 years and 4.03% in 1-3 years. Moreover, the Typhoid fever cases were significantly high (8.41%) in Pashtoon followed by (6.93%) in Baloch, (4.16%) in Punjabi and (1.53%) in Hazara. The 11.60 % Typhoid fever was observed in the patients with low socioeconomic status, 6.67% in middle socioeconomic status and 2.76% in the patients belonged to high socioeconomic status. The electrolytes imbalance results revealed that Sodium was low in 9.82% patients and Potassium was low in 7.21% patients while the calcium was low in 4.01% Typhoid patients. The significant Typhoid fever cases were reported in July (2.97%) August (3.13%) and September (3.92%) as compared to other months of the...
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Posted by admin on Sep 30, 2017 in |
Herb is an indispensable food ingredient for the tribal people of Arunachal Pradesh. They practices innumerable traditional food recipe to maintain good health. Spilenthes oleracea L. is one of such medicinal food plant used by tribal people of Arunachal Pradesh. The study was carried out to find out the phytoconstituents of S. oleracea shoot. Ethanolic extract of the sample was subjected to GC-MS to know the Phytoconstituents of this herb and correlate the phytoconstituents and health claim thereof if any. This study reports the presence of 48 phytocompounds and a total of 10 compounds identified from this sample have been reported to show painkiller effect that complements the traditional knowledge on this herb among the tribal people of the study site and scientific evidence. Sesquiterpene, Polyenoic fatty acid, Steroidal, Palmitic acid ethyl ester and Hydrocarbon are the major group of compound found from the sample. Present work advances S. oleracea as a medicinal food...
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Posted by admin on Sep 30, 2017 in |
Introduction: Obesity is a morbid condition characterized by abnormal or excess deposition of body fat to an extent that it adversely affects health. The basic etiology behind obesity is the disparity between the energy intake and energy expenditure. Lifestyle modifications and drug treatment is the mainstay of treatment. Unfortunately the benefits are for short term that might be because of cessation of drugs use or side effects which ultimately leads to rebound weight gain. Methods: Experiment was conducted on 42 adult healthy female wistar rats weighing around 150-200g, divided into 7 groups with 6 rats in each group. Group 1 given normal chow while others were given High Fat Diet (HFD). From 5th week till the end of 8th week group 3 to 7 were given respective drugs (extracts of Gymnema sylvestre and Acorus calamus). Obesity parameters (body weight, BMI, locomotor activity) were recorded on day 0, at the end of 8th week and at the end of 8th week. Internal organs (kidney, liver, spleen and heart) and fat...
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Posted by admin on Sep 30, 2017 in |
Biologically active compounds identified as flavonoids, glycosides, alkaloids, saponins, terpenoids and polyphenolics from plant extracts possess health promoting properties. The use of natural antioxidants in the treatment of various skin diseases has gained utmost importance in recent years. Therefore, present study was designed and conducted with the aim to evaluate the anti-inflammatory activity of cream formulation containing fruit extracts of Musa acuminata, Psidium guajava and Pyrus communis using in vitro model. Fruit of M. acuminata, P. guajava and P. communis were extracted by cold percolation, comprising of ethanol, methanol and distilled water. The cream formulation and the reference drug (Diclofenac sodium) of varying concentrations were incubated with fresh egg albumin under specified experimental conditions and subjected to determination of absorbance and viscosity to assess the in vitro anti-inflammatory activity. Linear regression analysis was used to calculate IC50 value. The results revealed that cream formulation and diclofenac sodium inhibited protein denaturation in a dose-dependent manner. The IC50 value of cream formulation 1254.13±16.91µg/ml and diclofenac sodium was recorded as 845.82±16.94µg/ml at correlation coefficient value...
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