Posted by admin on Aug 31, 2017 in |
The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on changes in circadian rhythm. Time dependent pulsatile drug delivery consists of a core tablets containing Candesartan cilexetil with different excipients surrounded by coating materials. Coating materials consist of combinations of hydrophilic polymer as HPMC and hydrophobic polymer as ethyl cellulose in various combinations. Formulated tablets were evaluated for its micromeritics as well as post compression characteristics such as weight variation, hardness, friability, drug content uniformity and in vitro drug dissolution. The drug-excipients study was carried out by using FTIR. In vitro drug release studies were performed using pH 6.5 phosphate buffers for 8 hrs. Optimized formulation F10 was selected and tested for its accelerated stability which was found...
Read More
Posted by admin on Aug 31, 2017 in |
Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and help to overcome non-communicable diseases like diabetes mellitus, obesity, hyperlipidemia, cardio-vascular diseases, etc. It is rich in micronutrients, especially vitamin B and minerals, Phytochemicals and dietary fiber. The phenolic compounds in minor millets also helps in the prevention of chronic diseases like Cancer. Minor millets like Paspalum scrobiculatum L., Panicum sumatrense Rothex Roem. and Schult, Eichinochola frumentacea Link and setaria italic (L.) P. Beauv. were chosen for the study. The bilaterally ovariectomized rat is an animal model for the studies related to menopause. The powdered minor millets were mixed with rat pellet and fed to the ovariectomised rats. After three months of the study, the blood...
Read More
Posted by admin on Aug 31, 2017 in |
Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting angiogenesis. In this present study we characterized the physicochemical and functional properties of endoglin gene using bioinformatics tools as this had not been studied previously. The three dimensional structure of endoglin was also computed using homology modelling and the reliability of the model was assessed by predicting its secondary structure along with validation. Additionally, using experimental evidence score, phylogenetic analysis and protein-protein network was framed between endoglin and its interacting neighbouring partners. These results are innovative and relevant enough to start prospective studies that will allow us to establish the relative strength of the prediction of diabetic retinopathy according to the endoglin levels presented...
Read More
Posted by admin on Aug 31, 2017 in |
SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets – control set (1) were kept in control conditions, while, rats of experimental set (2) were exposed to 80 ppm of SO2 gas 1h/d for 30 and 60 days and rats of experimental set (3) were exposed to 80 ppm of SO2 gas 1h/d with oral administration of Emblica officinalis fruits extracts (200 mg/kg b.wt.) for 30 and 60 days, respectively. The results exhibits that rats of 30 days showed non-significant (P > 0.05) decrease in plasma potassium ion concentration compared with the control while the rats of 60 days showed significant (P < 0.05) decrease in plasma potassium ion concentration compared with the control. The SO2 exposed subjects show significant (P < 0.05) decrease in...
Read More
Posted by admin on Aug 31, 2017 in |
Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical City (KAMC) in Riyadh, Saudi Arabia. All cases pertaining to hyperglycemia were identified from medical record archive of a random sample of patients admitted to KAMC, from January 2015 to December 2015. Patients with a previous history of diabetes were excluded from the study. The case/non-case method was employed to find association between identified drugs and hyperglycemia. The hyperglycemia risk was estimated by calculating the reporting odds ratios (ROR). The results reveal about one fifth of study population was admitted primarily due to hyperglycemia. A significant association for hyperglycemia has been shown with corticosteroids, immunosuppressants and anticholinergic agents with ROR = 2.63; 95% CI (1.26-5.51), ROR = 8.38; 95% CI (2.33-30.16) and ROR =...
Read More
