Posted by admin on Aug 31, 2017 in |
The prescription pattern of analgesic was investigated for the months of June, July, August 2016 by studying 253 (143 male + 110 female) BHTs of in patients of the orthopaedic department. The data mainly age, sex, diagnosis and line of management available from BHTs was analysed in the form of percentage, average of variable. The generic name cost of treatment per patient and rationality of prescription were evaluated by referring NLEM, CIMS, WHO indicators of drug utilisation. A total of 599 analgesics were prescribed to the patients. The average number of analgesic per prescription was 2.33. The maximum number of patients was in the age group of 41-51 years. Diclofenac was the most commonly prescribed analgesic 152 (26.2%).Only 51 patients received single analgesic and majority of patient received parenteral (45.6% i.m) preparations. Only 9 (1.0%) analgesics from NLEM but no generic name drug was prescribed. And again gastro protective drugs 240 (95.17%) and antibiotics 290 (114%) were frequently prescribed with the analgesics. The average cost of treatment per patient...
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Posted by admin on Aug 31, 2017 in |
The aim of this research was to formulate and evaluate microspheres of Fluoxetine Hydrochloride. It is a selective inhibitor of serotonin reuptake type of drug used in the treatment of depression. It is practically soluble in water belongs to BCS class I with a bioavailability approximately 72%. Fluoxetine HCl mucoadhesive microspheres were prepared by using chitosan polymer and emulsion solvent evaporation method which enhance bioavailability of drug. Microsphere with particle size in the range 192.92µm to 251.18µm was prepared. Fluoxetine HCl microspheres were evaluated for mean particle size, the percentage yield, entrapment efficiencies, in-vitro release, in vitro mucoadhesive, FTIR, DSC, X-ray diffraction studies and stability study. Formulation F9 microspheres batch was found to be optimized and followed zero-order release kinetic. The optimized formulation was mucoadhesive in nature. Stability studies were carried out for F9 at a temperature of 40±2 °C/RH 75±5% formulation revealed that the drug behaviour was within permissible...
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Posted by admin on Aug 31, 2017 in |
Background: Understanding the association of risk factors to adverse drug reactions is very important to all healthcare professionals for the development of appropriate preventive strategies for better health care. Objectives: To identify and evaluate the risk factors associated with adverse drug reactions developed in the hospitalized patients of different departments. Methods: A prospective-retrospective study was conducted in a tertiary care hospital for a period of twenty two months, with a specific criterion. Multiple logistic regression analysis was used. Risk factors included provisional diagnoses, suspected drugs which were classified according to ICD-10 classification and therapeutic classification respectively and also subjects’ age groups and gender were included. Results: A total of 204 cases’ were identified with adverse drug reactions during the period of study for which 1:1 ratio of controls were taken. During the study 175 subjects developed single ADRs (adverse drug reactions) and 29 had multiple ADRs. Causality assessment and severity of reactions were evaluated by using standard scales. Greater association to ADR were shown in the age group of...
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Posted by admin on Aug 31, 2017 in |
Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavonoids content of crude ethanolic extract and nine different fractions of C. album (sub sp. striatum). The in vitro antibacterial activity was evaluate against eight multidrug-resistant bacteria based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), agar well and disk diffusion methods. Antioxidant property was evaluated by 1, 1-diphenyl-2-picryl-hydrazyl radical scavenging activity. The total phenol contents were measured by Folin-Ciocalteu and AlCl3 assays. Our results showed that MeOH: H2O with 80:20 ratio (most polar) fraction had the highest antimicrobial effect on eight multidrug-resistant bacteria (MIC: 0.15-2.5 mg/ml, MBC: 0.31-5 mg/ml and had highest inhibitation zones (well: 24.33±0.57 mm and disk: 26.33±1.53 mm). In antioxidant assay, MeOH: H2O fraction also exhibited the highest radical scavenging activity [Antioxidant activity = 95.1±2.13...
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Posted by admin on Aug 31, 2017 in |
Background: The coronoid process of mandible is thin flat triangular process from the ramus of the mandible. This varies in the shapes and size. It gives attachment to two main muscles that is temporalis and masseter muscle. The coronoid process is the favourable donor site. A Coronoid process graft can be used for alveolar defects repair, orbital floor repair, maxillary augmentation, repair of non-union fracture of mandible. These grafts can be widely used in the reconstruction of osseous defects in oral and maxilla-facial region. Aim of the Study: This study is done to find out the variation in shape of coronoid process of mandible, Intercoronoid distance, coronoid- condylar distance and the length and breadth and thickness of the coronoid process of mandible. Methods: The study was done on the 100 dry human mandibles from the osteology bank of Saveetha medical college and hospital. The distance was measured using the digital vernier callipers and the values were analysed. Results: This study is useful for the maxillofacial surgeon and this useful...
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