Posted by admin on Feb 28, 2017 in |
In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antimalarial drug, artesunate, which has been used as an alternative antimalarial drug against conventional drugs like chloroquine. Thirty six male mice were divided into six experimental groups. In the present study, Allium sativum was given at 100 mg/kg body weight with low dose (150 mg/kg body weight) and high dose (300 mg/kg body weight) of artesunate for 14 days and 21 days duration. Obtained results showed significant alterations in gravimetric indices as well as biochemical parameters. Moreover, administration of Allium sativum exhibited recovery and reestablishment of various altered indices in renal tissue as opposed to artesunate treated groups. This study obviously demonstrated that treatment with Allium sativum significantly attenuated the renal toxicity...
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Posted by admin on Feb 28, 2017 in |
There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms. Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla, Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymaloides. Most of the family members of Euphorbiaceae have unique feature of possessing latex in their plant body. This latex is a secondary metabolite and hence has no significant physiological role in the plant system. An attempt has been made to find whether the plant extracts prepared in water have any role against fungi. These fungi are pathogenic to both plants and animals. The stem and leaves are thoroughly washed in 1% mercuric chloride and later washed in tap water followed by double distilled water. Later on crushed in mortar and pestle using water. The fungal species used for our study are Aspergillus niger, Saccharomyces cerevisiae and Fusarium oxysporum. The extracts are directly used...
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Posted by admin on Feb 28, 2017 in |
The study was undertaken with an aim to formulate anti-hypertensive agents as sustained release matrix tablets. The literature review showed that Indapamide is an anti hypertensive / diuretics in SR dosage form 50% of drug is released between 5-14hrs and 20-80ng/ml blood level is obtained for 24 hrs and SR form permits uniform and constant blood level after absorption of galenic form by oral route up to now it is available as IR with an dose of 2.5mg/day which results in considerable blood peaks, it is formulated as SR form to avoid and maintain constant blood level and to maintain better theraupetic index. In the present study, HPMC was found to play a great role in controlling release of drug Indapamide from the matrix system. Incorporation of HPMC K 100 M CR as release controlling polymer in extra granular fraction was found helpful in restoring the original and still closer release...
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Posted by admin on Feb 28, 2017 in |
Series of 1 of 1-[(3,5 diphenyl substituted ) -4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl) ethan-1-one (5a-5j) derivatives were synthesized by the reaction between indole 3 acetic acid hydrazide and various chalcones (3a-3j). The Chalcones were prepared by Claisen-Schmidt condensation reaction in which substituted aromatic aldehydes was treated with simple acetophenone(aromatic ketones) in presence of 20% base(NaOH) and indole 3 acetic acid hydrazide was prepared by reaction between 3 indole acetic acid with hydrazide. The synthesized new compounds were identified by spectral studies and elemental analysis, and were evaluated in vitro for their antimicrobial activity using standard agar diffusion method and using four bacterial strains (Bacillus, Pseudomonas, Escherichia coli and Staphylococcus) and two fungal strains (Sclerotium rolfsii & Macrophomina phaseolina) most of compounds such 5c.5a,5b,5f,5g i.e 1-[5-(4-Chloro phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl] – 2 – (3H-indol-3-yl) ethan-1-one (5c), 1-(3, 5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl) -2-(3H-indol-3-yl) ethan-1-one (5a), 1-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl) ethan – 1-one( 5b), 1-[5-(4 dimethyl amino phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl)ethan-1-one(5e), 1-[5-(4 Hydroxyl 3 Methoxy phenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl)ethan-1-one(5g). Shows good activity against gram positive and gram negative bacteria. All the compound exhibits moderate to average antifungal...
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Posted by admin on Feb 28, 2017 in |
The study objectives were to develop a unique expandable integrated floating film to be filled in capsule dosage form, which combines hydrophilic and hydrophobic polymers. The developed film was totally free from the concept of gas generating system or the low-density system, which floats merely due to Archimedes principle. A 32 full factorial design was used in the study with HPMC K100M (X1) and ethylcellulose cp10 (X2) as independent variables and time required for dissolution of drug and swelling as dependent variables. FTIR and DSC studies were carried out to investigate any drug excipient interaction. The XRD studies of formulation showed decreased crystallinity of the drug levofloxacin. Steady slow gel formation and the higher concentration of ethylcellulose, resulted in sustained drug release. The hydrophilic polymer readily expands the polymeric network within two hours. The predicted value of 90.419 and the actual drug release from the polymeric film were closely related to each...
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