Posted by admin on Apr 30, 2017 in |
Nelumbo nucifera Gaertn a perennial aquatic plant also known as sacred lotus. The Rhizome, flower, seeds and leaves all are edible and have been proved for their medicinal value. Study about its phyto-nutrients in the aerial parts are scanty. In the present study a phytoscreening of aerial parts of Nelumbo nucifera seeds and seed pod was done to assess and compare their phytoconstituents. Total phenolic content in Nelumbo nucifera seed pod was 93.45mg Gallic Acid Equivalents and 10.5mg/g in the seeds, the total flavonoid content was 295.312mg/g Quercetin Equivalents in NN seedpod and 28.125mg/g in the seeds, tannin content is 508.7mg/g Tannin Equivalents in Nelumbo nucifera seedpod and 69.637mg/g in seeds. Gallic acid, Quercetin and Tannin Equivalents were taken as standard for phenol, flavonoid and tannin content respectively. Phytochemical constituents analyzed by Gas Chromatography – Mass Spectrometry analysis of aerial parts Nelumbo nucifera can be used for routine quality control analysis. The data obtained emphasize, the potential of traditional medicine Nelumbo nucifera, whose phytoconstituents form a source of natural...
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Posted by admin on Apr 30, 2017 in |
The present investigation was carried out to study the disintegrant property of Plantago ovata and Ocimum basilicum mucilages. The objective of the work was to develop Fast disintegrating tablets of Ondansetron HCl with a view to enhance patient compliances and dissolution rate by direct compression method using 3² full factorial design. Plantago ovata (2-10% w/w), Ocimum basilicum (4-8%w/w) mucilages were used as natural superdisintegrant and microcrystalline cellulose was used as diluent, along with directly compressible mannitol to enhance mouth feel. The tablets were evaluated for hardness, friability, thickness, drug content uniformity, in vitro dispersion time, wetting time and water absorption ratio. Based on in vitro dispersion time (approximately 11 s); the formulation containing 10% w/w Plantago ovata and 8% Ocimum basilicum mucilages were found to be promising and tested for in vitro drug release pattern (in 0.1 N HCl), short-term stability (at 40º/75 % RH for 6 mo) and drug-excipient interaction. Surface response plots are presented to graphically represent the effect of independent variables (concentrations of Plantago ovata and...
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Posted by admin on Apr 30, 2017 in |
Background: Hyperglycemia may induce endothelial dysfunction. Chromium Supplementation enhances endothelial relaxation and may improve endothelial dysfunction. Present study was planned to evaluate effect of proprietary chromium complex(PPC) and its individual components on endothelial dysfunction and lipid profile in type 2diabetics. Methodology: Study was done in two parts. In part I, PPC 400mcg produced significant improvement in endothelial function compared to PPC 200mcg and placebo. In part II, 96 eligible subjects were randomized to chromium chloride 400mcg, Phyllanthus emblica 6mg and Shilajit 6mg, chromium picolinate 400mcg, chromium polynicotinate 400mcg and chromium dinicocysteinate 400mcg and compared to PPC 400mcg. Efficacy parameters were change in endothelial function(>6% change in reflection index(RI), biomarkers of oxidative stress and lipid profile after 12weeks treatment. Laboratory safety parameters were measured at baseline and post treatment. Results: Total 96 subjects completed the study. PPC 400mcg produced better improvement in reflection index (−3.34%±1.00% to −7.23%±1.88% (p<0.001) compared to chromium chloride 400mcg (-3.79%±0.82 to-3.22%±0.85), Phyllanthus emblica 6mg and Shilajit 6mg (-1.44%±0.58 to-5.67%±0.54), chromium picolinate 400mcg (-4.68%±1.24 to -2.46%±0.90), chromium...
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Posted by admin on Apr 30, 2017 in |
The multidrug-resistant strains are a major problem in the control of infections in hospitals. The smaller size of nanoparticles is gaining importance in research for the treatment of various diseases. The main objective of this study is synthesis of silver nanoparticle in eco-friendly manner without using any hazardous chemicals. Stable and spherical shaped nanoparticles Synthesized by using aqueous leaf extract of T. alata. This method offers a viable and an eco-friendly way for fabrication of benign nanoparticles as it is a simple and carried out at room temperature without any huge inputs in terms of energy and waste. It is advantageous over the microbial synthesis as it is carried out using in aqueous solutions at ambient temperature, without any toxic chemicals in lesser time and could be exploited for developing cost effective biosynthesis of Ag nanoparticles at a large scale. One more aim of this study is that analysis of antimicrobial activity of biogenic nanoparticles against disease causing human pathogens. Characterizations of nanoparticles were done by UV-Vis spectroscopy, FTIR,...
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Posted by admin on Apr 30, 2017 in |
Sumatriptan succinate, a selective 5-hydroxytryptamine-1 receptor agonist, is an antimigraine drug with bitter-taste. The present study was performed to prepare and evaluate eudragit-E microparticles containing sumatriptan and formulate fast disintegrating tablets of drug microparticles to increase patient-compliance and improve the efficacy of drug. Microparticles were prepared by solvent-evaporation method using water-dichloromethane/PVA and water-dichloromethane/liquid paraffin systems. The effect of different variables (polymer:drug ratio, PVA concentration and solvents combination ratios) on particle size and encapsulation efficiency of the microparticles was investigated. The final microparticles were evaluated for particle size, loading percent, taste-masking, thermal analysis and in-vitro release profile. The drug loading were higher in w/o/o emulsion than w/o/w. Mean particle size was not statistically different for different formulations. Sumatriptan release rate from eudragit-E microparticles was very fast in HCl 0.1 N medium and release profile was acceptable for fast disintegrating tablets. The prepared tablets were evaluated for in-vitro disintegration time, weight variation, hardness, friability and in-vitro drug release. The optimized formulation (F6) (provided a pleasant taste and mouth-feel) disintegrated within 20...
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