Posted by admin on Mar 31, 2017 in |
Prodrug approach is a new frontier that reinforces the concept of green chemistry in the pharmaceutical chemistry field. The combination of a suitable synthesis and the strategy of the prodrug is of huge advantage for pharmaceutical industries. In this paper, we compare the conventional synthesis of new galactosylated NSAIDs prodrugs with green strategies and demonstrate how we can move away from the use of harmful substances using a suitable method for the synthesis of new compounds. So, we decided to investigate the use of potentially cleaner solvents and reagents such as room temperature ionic liquids, hydrochloric acid and glacial acetic acid. Furthermore, the chemical and enzymatic stabilities of new NSAIDs prodrugs were evaluated in order to determine both their stability in an aqueous solution at pH=1 and pH=7.4 and their feasibility in undergoing enzymatic cleavage by plasma to regenerate the original drug. Results concerning green synthetic approach clearly showed a reduction of time and waste. Moreover, these prodrugs are susceptible to degradation in rat plasma but stable to chemical...
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Posted by admin on Mar 31, 2017 in |
Objective: PCOS is a common endocrine disorder in women of reproductive age associated with insulin resistance. Metformin and Myo-inositol being insulin sensitizers improve biochemical parameters. This study was done to compare the effects of these drugs on biochemical profile in PCOS. Material and Methods: A prospective, open labeled, randomized, comparative, clinical study was conducted on 60 patients. The patients were randomly divided in two groups of 30 each to receive either of the following two treatments: Group A: Tab Myo-inositol 1g twice daily & Group B: Tab Metformin 500 mg thrice daily for 24 weeks. Biochemical profile was assessed by measuring fasting blood sugar, insulin levels & calculating glucose/insulin ratio and homeostatic model assessment- insulin resistance (HOMA-IR) index at baseline and subsequently at the end of 12 & 24 weeks. Serum Lipid profile was also assessed. Results: In both the groups, there was statistically significant improvement in insulin resistance. In group A & group B, the values for glucose/ insulin ratio improved from 6.77±0.99 to 7.87±1.03 and 5.5±0.42 to...
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Posted by admin on Mar 31, 2017 in |
Trigonella foenum (T. foenum), Trachyspermum copticum (T. copticum) and Nigella sativa (N. sativa) are important medicinal plants that need to be explored for their anti-oxidant potential. The aim of the present study was to evaluate the total anti-oxidant potential of methanolic extracts of T. foenum, T. copticum, N. sativa and the combination of these methanolic extracts in 1:1:1 ratio (Combination 1:1:1). The total phenolic content of the methanolic extracts of T. foenum, T. copticum, N. sativa and the Combination 1:1:1 was evaluated. Further the total anti-oxidant activity of the extracts was assessed by determining their total reducing capacity, DPPH radical scavenging activity and lipid peroxidation inhibition potential. The total reducing capacity was found to be 75.61, 115, 110.97 and 128.65 equivalents of ascorbic acid (μg)/mg for extract of T. foenum, T. copticum, N. sativa, Combination 1:1:1 respectively. The IC50 for DPPH radical scavenging activity obtained for T. foenum, T. copticum, N. sativa and Combination 1:1:1 was 2428.45, 316.18, 457.94 and 107.85 µg/ml respectively. The inhibition potential of lipid peroxidation...
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Posted by admin on Mar 31, 2017 in |
Ginger has shown to benefit in muscular pain due to eccentric exercise and in osteoarthritis but a later review denied these properties due to uncertainties. To ascertain the reality, this study was proposed. Methods: (A) Albino rats (n=6-12) were administered G.J at single dose (4 ml/rat, p.o) as single administration (acute) and chronic treatment 4ml/rat p.o over period of 7 days. Following this assessment was done. Effect of treatment with G.J acutely and chronically (7 days) administered, was assessed. Parameter used during assessment was head twitches. Results: Chronic treatment of ginger-juice induced the head twitches significantly. Acute treatment with ginger-juice did not affect this activity. Chronic treatment increased the number of head twitches induced by lithium. Conclusion: Lithium induced head twitches were enhanced after chronic administration of...
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Posted by admin on Mar 31, 2017 in |
Now a day the exposure of multi-resistance human pathogens has challenged our existing defense to save human being. To minimize such alarming issue, identification of naturally-occurring antimicrobial agents from plant origin has become a realistic and powerful tool to the researchers. Therefore the aim of this study was to investigate the antimicrobial potential of the ethanolic extracts of different parts of Abelmoschus moschatus (A. moschatus) against some important human bacterial and fungal pathogens. Different parts (leaves, stem bark, fruits pulp and seeds) of A. moschatus were extracted with ethanol to get crude ethanolic leaves (LE), stem bark (SBE), fruits pulp (FPE) and seed extracts (SE). Antimicrobial activity of LE, SBE, FPE and SE were assessed by disk diffusion and serial dilution method. All the extracts showed moderate antimicrobial activity against all tested pathogens. Among the extracts LE was comparatively highly sensitive against all tested pathogens. In case of S. dyesenteriae and S. sonnei zone of inhibition of LE (26 and 28 mm diameter with MIC 31.25 and 62.5 µg/ml;...
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