Posted by admin on Mar 31, 2017 in |
In order to improve the water-solubility of curcumin, the complex between curcumin and hyperbranched poly(amide-ester) was formed by dispering the solid curcumin in hyperbranched poly(amide-ester) aqueous solution. The interaction process was characterized by UV-vis absorption spectroscopy, Fluorescence quenching method, Fourier transformation-infrared spectroscopy, thermogravimetric analysis. Fluorescence quenching ananlysis reveal that the fluorescence quenching of curcumin is due to the formation of ground state complex between curcumin and hyperbranched poly(amide-ester) and the binding constant was 3.98×105L·mol-1. The other analysis also can prove the formation of complex between curcumin and HBPAE. The solubility of curcumin in aqueous solution was greatly increased more than 1000-fold at the presence of hyperbranched...
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Posted by admin on Mar 1, 2017 in |
Mn(II) complexes with four semicarbazide and thiosemicarbazide based ligands such as 2-formyl pyridine semicarbazone (L1), 2-formyl pyridine thiosemicarbazone (L2), 5-methyl 2-formyl pyridine semicarbazone (L3) and 5-methyl 2-formyl pyridine thiosemicarbazone (L4) have been synthesized and characterized. All the ligands were characterized by elemental analyses, IR, 1HNMR and mass spectral studies. The complexes were characterized by using various physicochemical techniques such as elemental analysis, molar conductance, magnetic susceptibility measurements and spectral studies such as IR, UV-visible and EPR. The complexes were found to have general compositions Mn(L)2X2 [where L = L1, L2, L3 & L4, X = Cl–, NO3–]. The molar conductance data of chloro and nitrato complexes of L1, L2, L3 and L4 suggest nonelectrolytic nature of the complexes. Therefore they may be formulated as [Mn(L)2X2].Complexes show magnetic moment corresponding to five unpaired electrons. On the basis of IR electronic and EPR spectral data distorted octahedral geometry of complexes has been...
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Posted by admin on Feb 28, 2017 in |
Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark was extracted with aqueous ethanol (70%) and quantitative analysis for total phenolic content, total alkaloids and flavonoids was carried out on the dried extract. The hypoglycaemic effects of aqueous A. stenophylla root bark extract, powdered Zingiber officinale and powdered Citrus Limon peels was determined on alloxan-induced diabetic rats singly and in combinations over 14 days. Glibenclamide administered at 0.2 mg/kg b. wt was used as the positive control. Results: All the plants decreased plasma glucose levels in a dose-dependent manner. The glucose levels of diabetic rats treated with all the plants combined showed the greatest reduction (59.2%). A. stenophylla and Z. officinale showed a glucose level reduction of 47.7%, A. stenophylla and C....
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Posted by admin on Feb 28, 2017 in |
Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal stability of Ag/PVA were evaluated applying Thermal Gravimetric Analysis (TGA), the decomposition temperature increase from 302 0C for pure PVA to 345 0C for irradiated Ag nanofillers /PVA with ion beam fluence 3.0 x 1018 ions.cm-2 at 0.8 % AgNO3 concentration . Fourier transform infrared spectroscopy (FT-IR) exhibits the creation of polar groups on the surface which are responsible for surface wettability improvement. From the above, this procedure is simple and useful for large scale synthesis and which make this material as a candidate medical devices and for drug delivery...
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Posted by admin on Feb 28, 2017 in |
Objectives of study: To develop and validate new, rapid, selective, precise, accurate and economical, isocratic RP-HPLC and UV spectrophotometric method for simultaneous estimation of Dextromethorphan and Quinidine in bulk and in tablet formulations. Methods: A RP-HPLC was developed for the simultaneous estimation of Dextromethorphan and Quinidine on Phenomenex C-8 column with the mobile phase of methanol and phosphate buffer (pH 2.5) in the ratio 60:40 v/v at flow rate of 1ml/min and detection at 230nm was used for the study. In UV spectrometry, simultaneous equation method was based on measurement of absorbances at two selected wavelengths 278nm and 331nm for Dextromethorphan hydrobromide and Quinidine Sulfate respectively. Absorbance ratio method based on the measurement of absorbances at isobestic point and wavelength maxima of one drug, selected wavelengths were 278nm (λmax of DMH) and 289nm (isobestic point). The developed methods were validated and recovery studies were carried according to ICH guidelines. Results: The peaks of Dextromethorphan and Quinidine were found to be well resolved with retention time of 4.3min and 2.8min...
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