Posted by admin on Dec 31, 2016 in |
The aim of present study is to formulate and optimize the site specific controlled release formulation for release of loratadine in upper gastrointestinal tract. Superposrous hydrogel hybrids (SPHH) were prepared by using ferric chloride as crosslinking agent and sodium carboxymethyl cellulose as composite agent. The Superporous Hydrogels were evaluated for swelling ratio, mechanical strength, density, porosity, scanning electron microscopic studies. Statistical software, Design Expert was used for optimization and chosing the final formulation. Loratadine hydrochloride was loaded in optimized formulation and characterized by Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, Differential Scanning Calorimetry and in vitro drug release studies. Superporous Hydrogel Hybrids were prepared with desired mechanical strength and sufficient swelling ratio. Equilibrium Swelling Ratio of hydrogels followed the pattern SPHH < SPHC < CSPH. The pattern may be attributed to the additional crosslinking and decreased poresize. Reduced swelling ratio may be because of restricted polymeric chain flexibility. H- bonds between poly (AM-co-AA) and NaCMC reduced the polymer ability to form H-bonds with water molecules, limiting water absorption. Increase in...
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Posted by admin on Dec 31, 2016 in |
A simple, selective, rapid, precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine besylate and Telmisartan in tablet dosage form as per ICH guidelines. The wavelength selected for the analysis was 239 nm for amlodipine besylate, telmisartan and hydrochlorothiazide. The solvents used were methanol and distilled water. The mobile phase 0.05M Potassium dihydrogen ortho-phosphate (pH-3.2), acetonitrile and methanol in the ratio 45:45:10 was used to carry out the separation. Column used was Supelco C18 (250 x 4.6 mm, 5μ). Flow rate was selected as 1ml/min. Retention time for Hydrochlorothizide (HCT), Amlodipine besylate (AML) and Telmisartan (TEL) was found to be 2.9min., 5.1min., 8.2min. The developed method was validated for accuracy, precision, linearity, robustness, ruggedness, specificity. The proposed method can be used for the estimation of these drugs in combined dosage...
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Posted by admin on Dec 31, 2016 in |
Awareness of reproductive health is rights of humans and lack of accurate notification will lead to numerous complications.Pre-marriage is one of the best times to training of these issues. Therefore, this study was done in order to evaluation the effects of premarital education on the girls’ awareness about reproductive health. In this semi-experimental study, 152of womens that participated in courses at marriage counseling center were selected with consecutive sampling method in Garmsar city, Iran in 2012.Data were collected by a questionnaire containing demographic (contains two sections: demographic characteristics and reproductive health) in two stages of pre and post of test. Data were analyzed using SPSS software. According to the findings of this research, the average of girls’ age was 22.41± 3.22 and 55.3% of them, had college education and 53.9% of them were housewives. The mean score of awareness about reproductive health before the education, was 12.81±33.3 that increased to the 17.81±. 2.587after training and this difference was statistically significant (p= 0.000).As well as level of satisfaction of participants...
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Posted by admin on Dec 31, 2016 in |
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are useful in the treatment of serious bacterial infections thus keeping in view a potential approach is made for synthesising & characterizing of newer quinolone derivatives for their biological activity. Method: Quinolone ester was synthesised from Gould-Jacob reaction by using substituted aniline & diethylethoxymethelene malonate (EMME) Results: Solubility of all synthesised compounds were checked in various solvents & were characterized by FT-IR, 1H-NMR. Conclusion: The result of the present study thus demonstrates the anti-microbial activity against gram positive (Bacillus subtilis) & gram negative (Escherichia coli)...
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Posted by admin on Dec 31, 2016 in |
Increasing use of bioinformatics made very easy to researchers in biological and drug discovery field. Bioinformatics is involved at each and every step of drug discovery to drug development. The first step of the drug discovery is a question about disease and the treatment by drugs and whenever term drug comes, means something has to be given and the second question arises the given compound is drugable or not. To check any drugable compound the compound has to be cleared by the ADME studies and the main sensitive parameter blood brain barrier. Bioinformatics made it easy without use of model organism and waste of time. In this study we aimed to predict the blood brain barrier parameters on 87 drugs about their drug...
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