Posted by admin on Feb 28, 2017 in |
Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant in comparison to control group and the observed efficacy was comparable to standard drug. The efficacy of the polyherbal preparation was found to be dose dependent. From the present study it is evident that the Polyherbal preparation has no mortality in selected doses. Liver antioxidant markers were elevated significantly, while the serum and lipid parameters were maintained at normal levels compared to control groups. Histopathological examinations of the liver showed that extract and Silymarin have a protective role over the toxicity of paracetamol and carbon tetrachloride induced hepatotoxicity in rats. Hence Polyherbal preparation could be one of the best sources of natural hepatoprotective...
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Posted by admin on Feb 28, 2017 in |
An ethnobotanical study of medicinal plants was carried out in the region of Oued Tlelat. It was made in order to establish the catalog of medicinal plants and gather all information on the therapeutic uses practiced by the local population in the study area. The results have identified 59 species that are divided into 29 families of which three are the most dominant, especially Lamiaceae, Apiaceae, and Fabaceae. The most cited plants Thymus vulgaris, Menthaspicata and Verbena officinalis. The foliage is the most used part and most of the remedies are prepared as an infusion. In terms of treated diseases, respiratory diseases occupy first place with a rate of 31.74%. This study highlights the medicinal plants used in the treatment of different type’s diseases (Respiratory, metabolic disorders, neurological disorders, dermatological infections, genitourinary infections) by the population of the study area. The results are a valuable source of information and a database for research in the field of...
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Posted by admin on Feb 28, 2017 in |
The objective of the present study is optimization of telmisartan tablet formulation employing βCD, Primojel, and Tween 80 by 23 factorial design to achieve NLT 85% dissolution in 10 min. Eight telmisartan tablet formulations were prepared using selected combinations of the three factors as per 23 factorial design. Telmisartan tablets were prepared by direct compression method and were evaluated. Telmisartan tablet formulations Fb and Fbc disintegrated rapidly in 20 and 40 seconds and gave very rapid dissolution of telmisartan, 96.1% and 95.8% in 10 min respectively. The increasing order of dissolution rate (K1) observed with various formulations was Fc< F1< Fac< Fa< Fabc< Fab< Fbc< Fb. The polynomial equation describing the relationship between the response, percent drug dissolved in 10min (Y) and the levels of βCD (X1) , Primojel (X2) and Tween 80 (X3) based on the observed results is Y = 55.327 + 3.613(X1) + 35.072(X2) – 9.182(X1 X2) – 3.757(X3) – 3.317(X1 X3) + 2.06(X2 X3) + 1.765(X1 X2 X3). Based on the above equation, the formulation...
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Posted by admin on Feb 28, 2017 in |
Despite significant progress made in the treatment of infectious diseases, caused by bacteria and fungi, it remains a major worldwide health problem due to rapid development of resistance against the existing antimicrobial drugs. In the present investigation, a novel series of chalcones 2a–2h were synthesized by the clasein-schmidt condensation of various aldehydes with methyl ketone in the presence of KOH in ethanol which lead to the formation of new chalcones. The structures of these compounds were elucidated by, IR, 1H-NMR spectral data. The in vitro antibacterial activity of these compounds was evaluated against two Gram positive and two Gram-negative bacteria Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa by microdilution method and then the minimum inhibitory concentration (MIC) of these compounds was determined. The results showed that compounds 2d, 2e and 2h showed most promising antibacterial activity as compared to the antibiotics ciprofloxacin in (Tables 1). Compound 2e which carries the nitro substituent appears to exhibit the highest antibacterial activity against all gram positive and gram negative...
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Posted by admin on Feb 28, 2017 in |
Understanding the mode of inhibition through the crystal structures of EGFR kinase domain complex with small molecule inhibitors provides us to search for potential ligands of EGFR. The binding mode analysis of pyridopyrimidine analog reveals that the presence of hydrogen bonds between the target protein amino acid Met 793 (i.e. the hinge region which is responsible for catalytic activity of the domain) and the ring nitrogen of the small molecule inhibitor. In addition, amino acid Asp 855 and Lys 745 were also involved in the interaction. The present work focuses on the identification of novel ligands through computational approach. By screening of pubchem database compounds, based on the bioactive and structural similarity of a pyridopyrimidine derivative (highly potent inhibitor of EGFR), 117 compounds were identified and all are having kinase inhibition activity but were not analyzed in EGFR. Using GLIDE software, the docking was done and complete analysis of the binding mode results in eleven compounds having same pattern of interactions and these compounds may be further analyzed by...
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