Posted by admin on Dec 31, 2016 in |
Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all ingredients which is used for making the final product tablet. Final product tablet is made by the addition of bulk drug and excipients. The continuous evolution of the bulk drugs and excipients can only ensure the quality of final product. Moisture content of API’S and excipients plays a very important role to manufacture the final product. It is may affect the physical and chemical properties of final product. Moisture content affects the physical, chemical and microbiological properties of pharmaceutical finished dosage forms. In direct compression process, high and extra low moisture content could be it affects the hardness of tablet. For satisfactory hardness of tablet, room temperature and humidity must be maintained in a specific limit. Tablet hardness is also most import parameter for any solid dosage...
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Posted by admin on Dec 31, 2016 in |
Introduction: Medical students of present era have to prove their efficiency in every step of life. To do so one has to become a competent doctor. This is possible only with the proper knowledge and application of the rational therapeutics in clinical practice. This can happen when the students are motivated and taught medicine in such a way that can produce better learning. The clinical aspect of medicine is usually touched in very theoretical way at present. This way of teaching pharmacology lacks the proper correlation of medicine and the disease (and patient). Students are hesitant in using the drugs related to cardiovascular system and are unable to handle the cardiovascular emergencies. Students practice irrational therapeutics. With this background idea, this project was taken up to enable our students to get better understanding of medicines. The project was a type of pilot study of its own kind to explore new mode of supportive teaching of pharmacology. Aim and Objectives: To know the impact of bedside teaching of clinical aspects...
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Posted by admin on Dec 31, 2016 in |
Three marine soil samples collected at various seashores of the Bay of Bengal near Chirala Coast of Andhra Pradesh were screened for the isolation of lipolytic Actinobacteria by tributyrin agar clearing method. The isolates were cultured under submerged fermentation conditions and assayed for their extra cellular lipase producing capabilities using olive oil as substrate. Enzyme profiling of the selected strain was done by incorporating the respective substrates in the media. The different parameters namely, morphological, biochemical, physiological and molecular were used for the characterization and identification of actinomycetes isolates. The secondary structure and restriction site of selected actinomycetes were predicted using bioinformatics tools available online. Results indicated that all the isolates showed lipolytic activity after primary screening. These isolates were subjected to secondary screening and lipase activity is estimated quantitatively. Morphological, cultural, physiological and biochemical characteristics as well as enzymatic activities suggested that all the isolates belonging to the genus Streptomycetes. The marine isolate RPBS-A4 was the most active one and thus was selected further identification. The 16S rDNA...
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Posted by admin on Dec 31, 2016 in |
Although there are numerous studies on antimicrobial activities of mushrooms against many common pathogenic microorganisms, there is hardly any study against Brucella spp., responsible for brucellosis in animals and human beings throughout the globe. The present study was aimed to evaluate the in vitro antimicrobial activities of ethanol extracts of five edible mushrooms namely, Pleurotus ostreatus, Pleurotus florida, Pleurotus eous, Pleurotus sajor-caju and Calocybe indica against four reference strains of Brucella spp.: B. abortus S19, B. abortus S99, B. melitensis M16 and B. suis 1330. Methodologies adopted were disc diffusion assay, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extracts. Evaluation of the antioxidant capacity of the extracts of the mushrooms by DPPH free radical scavenging activity was also aimed in this study. The total phenol content of the mushrooms showed significant positive Pearson correlation with the antioxidant capacity of the extracts. The results obtained revealed the antimicrobial potency of all the screened mushrooms against Brucella spp. P. sajor-caju had highest phenolic content, which may be...
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Posted by admin on Dec 31, 2016 in |
Let G be a simple molecular graph with vertex and edge sets V(G) and E(G), respectively. In 1972, Gutman and Trinajstić introduced the First and Second Zagreb topological indices of molecular graphs. These topological indices are useful in the study of anti-inflammatory activities of certain chemical instances, and in elsewhere. In this present study, compute the First Zagreb index Zg1(G)= and Second Zagreb index Zg2(G)= and the First Zagreb polynomial Zg1(G,x)= and the Second Zagreb polynomial Zg2(G,x)= of V-Phenylenic Nanotubes and...
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