Posted by admin on Jan 31, 2017 in |
The aim of the present study was to prepare and evaluate floating microspheres consisting of (i) calcium silicate (CS) as porous carrier; (ii) famotidine and (iii) hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) as polymers. The floating microspheres were evaluated for particle size, micromeritic properties, percent drug content, in vitro floating behavior, and in vitro drug release. The % yield of formulations (FM1 to FM9) was found to be in the range of 79.51 ± 3.71 to 93.48 ± 0.94 %. Percentage drug content of floating microspheres formulations (FM1 to FM9) was found in the range of 77.25 ± 0.36 to 86.14 ± 2.04 %. In Vitro Buoyancy percentage of the microspheres was found to be 97.5 ± 1.53 %. At pH 1.2, the best formulation FM4 showed maximum drug release (99.26 ± 1.14 %) at the end of 12 hr. The SEM photographs of formulation FM4 showed that the fabricated microspheres were spherical with a smooth surface and exhibited a range of sizes within each batch. The in vivo...
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Posted by admin on Jan 31, 2017 in |
The aim of this study was to analyze the chemical composition of dried clove buds volatile oil in Bangladesh by Gas Chromatography-Mass Spectrometry (GC-MS) technique and also show their medicinal properties according to the characteristics of the constituents present in that essential oil. In this experiment the clove buds essential oil was extracted by hydro distillation method. The major constituents obtained from the oil includes 3-Allyl-6-methoxyphenol i.e. m-Eugenol (69.44%), Eugenol acetate (10.79%), 4-hydroxy-4-mehtylpentan-2-one i.e. Tyranton (7.78%) Caryophyllene (6.80%), 1,4,7-Cycloundecatriene, 1,5,9,9-tetramethyl-,Z,Z,Z-and trace amounts (<1%) of other constituents. Eugenol is present in concentration of 69.43% which is the major volatile constituent of clove bud essential oil. It has wide range of medicinal value such as antiseptic and anaesthetic analgesic, antioxidant, anti-inflamatory and antimicrobial activities. Clove oil is used in dental care and it can relieve toothache temporarily. So, from these chemical constituents it is clear that clove buds essential oil of Bangladesh has medicinal properties because of the medicinal characteristics of these...
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Posted by admin on Jan 31, 2017 in |
The aim of the present work was to develop a new microbeads system for colon-targeted delivery of celecoxib. The ternary system were develop using PVP (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HPB) to increase solubility of celecoxib. DSC and XRD results confirmed formation of amorphous celecoxib complex with HPB. Chitosan and pectin were used for the development of microbeads of new amorphous celecoxib. Calcium chloride was use as cross linking agent for electrolyte complexation between polymers. Eudragit RS100 was used to embed into microbeads in order to avoid premature delivery of a drug in acidic environment of stomach. Statistical design of experiment was employed to investigate the combined effect of three formulation variables, i.e., % of chitosan, pectin, and CaCl2, on responses like drug release pattern in acidic dissolution medium (CDR in UGIT), colonic dissolution medium with fungus culture of Aspergillus niger (CDR in LGIT) and drug entrapment efficiency (EE%). Response surface methodology was used to analyze multivariate approach for understanding the multifactorial relationships among formulation parameters. Full central composite design was...
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Posted by admin on Jan 31, 2017 in |
Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were randomly divided into five groups (n = 6) and treated as per treatment protocol with three different dose of Ginkgo biloba extract (125, 250, and 500 mg/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with Isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group II) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Ginkgo biloba extract in all three dose (group III, IV and V) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes ( reduced glutathione (GSH), superoxide dismutase (SOD)...
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Posted by admin on Jan 31, 2017 in |
Introduction: Pharmaceutical care entails the work of addressing patient’s medication related needs and problems. The involvement of the pharmacist in India in this regard has been somewhat restricted, contrary to trends in developed countries. Materials and methods: Questionnaire-based explorative, semi-quantitative study involving Doctors, Pharmacists and Nurses of the study department in the following sequence; Design of questionnaire, Pre-testing/validation, Administration, Collection, Evaluation & Interpretation. Results: Out of total 90 questionnaires distributed among health care providers the response rate was measured as 63.3% and less than 40% of the Health Care Providers could answer correctly to the first section of questionnaire intended to assess the knowledge regarding pharmaceutical care. In the perception part 73.3% of doctors agreed and 20% strongly agreed that pharmaceutical services provided by clinical pharmacist can improve the quality of patient care in hospital settings. 66.6% agreed and 26.6% strongly agreed that clinical pharmacist as a part of medical team will minimize medication errors. 73.3% agreed and 20% disagreed that doctors can allow pharmacists to be available with...
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