Posted by admin on Feb 28, 2017 in |
A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program called VALSTAT. The best models were selected from the various statistically significant equations. The study revealed that descriptors molecular weight (MW) and Connolly solvent excluded volume (cn sev) reduces the activity, where as molar refractivity (MR) enhances the anticancer activity. The analysis resulted in QSAR equation, which suggests that, n=27, r = 0.9115, r2 = 0.8308, adjusted r2 = 0.8087, standard deviation (std) = 0.0915 and q2 = 0.7644. The results obtained from QSAR studies could be used in designing better anticancer agents among the congeners in...
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Posted by admin on Feb 28, 2017 in |
Some new hydrazino group substituted benzothiazole derivatives have been synthesized and their characterization was done by IR, NMR and MASS spectral data. The antimicrobial activities of these synthesized compounds was done by cup-plate diffusion method in DMSO against some Gram positive and Gram negative bacteria. Some of synthesized derivatives exhibited potent activity when compared with standard drug...
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Posted by admin on Feb 28, 2017 in |
Reverse Phase – High performance liquid chromatographic (RP – HPLC) method was described for determination of Ambroxol Hydrochloride (AMB) and Cefadroxil Monohydrate (CEFXL). The chromatographic separation was achieved using mobile phase mixture of Acetonitrile and 0.05 M Dihydrogen Phosphate Buffer (pH 3.0 adjusted with Ortho Phosphoric Acid Solution) in the ratio of 40:60 (%v/v) and Eclipse Plus C18, (150 x 4.6 mm i.d), Particle size 5 mm column at 1.0 ml/min flow rate. 20 µL of standard preparation containing 30 µg/ml AMB and 250 µg/ml CEFXL was injected into the column and the component was separated by carrying out elution for a run time of 15 minutes and detected at 230 nm wavelength. The described method shows excellent linearity over a range of 6 to 60 μg/ml and 50 to 500 μg/ml for AMB and CEFXL, respectively. AMB and CEFXL were subjected to stress degradation conditions of hydrolysis (acid and base), oxidation and thermal degradation. Stressed samples were analysed by the developed method. The proposed method was readily applied...
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Posted by admin on Feb 28, 2017 in |
Impaired carbohydrate and lipid metabolism with amplified oxidative stress are well recognized factors for Coronary artery disease (CAD) which is the major reason of mortality and morbidity all over world. The incident of CAD with type 2 diabetes mellitus (T2DM) is growing and they are predicted to be the biggest cause of death by 2020 in India. Therefore, the venture of the present study was to assess the association of hyperglycemia, oxidative stress, antioxidant enzymes, lipid profile and lipoprotein components in serum of CAD with T2DM patients as well as to compare the results with age-sex matched healthy human volunteers. Five hundred participants were enrolled for the present study, with their ages ranging from 37 to 57 years from OPD of medicine, Era’s Lucknow Medical College & Hospital, Lucknow, were attending OPD for routine medical checkup. Out of which two hundred fifty were clinically new diagnosed case of CAD with T2DM like hyperglycemia, angina pectoris and Myocardial infarction (MI), remaining two hundred fifty were healthy controls. All biochemical assays...
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Posted by admin on Feb 28, 2017 in |
Aims: To evaluate and analyze effectiveness of animal simulation based teaching in pharmacology in comparison to conventional methods to undergraduate medical students. Methods: An interventional and comparative study was conducted among second professional MBBS students. All students were divided into two groups A and B. Four demonstrations of experimental pharmacology were demonstrated by conventional method and animal simulation method by same teacher. Both groups were equally exposed to both modes of demonstrations. Every demonstration was followed by an assessment containing thirty objective type questions. Feedback was taken to analyze generalized opinion about the programme on likert’s scale. The data was analyzed by using Fisher’s exact test and p value calculated. Results: Percentage of students who scored 60% or more was higher in simulator based teaching in assessment related to procedure, related pharmacology and applied pharmacology. The difference between total scores of both groups in all four demonstrations was statistically significant with p value < 0.05. In feedback, percentage of students who opted three or more on likert scale was...
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