Posted by admin on Feb 28, 2017 in |
Objective: To evaluate drug utilization pattern among geriatric patients in outdoor as well as indoor departments of the hospital. Methods: Observational, prospective study was conducted from March 2014 to March 2015 among 600 geriatric patients; demographic details, education, occupation, diagnosis and drug details were recorded. The drugs were categorized by anatomical therapeutic classification and defined daily dose was calculated. The World Health Organization prescribing indicators and potentially inappropriate medicines (PIMs) according to Beers criteria were assessed. Results: The majority of the patients (75%) were in age group of 65-74 years. Cardiovascular diseases were common among geriatrics. Most commonly prescribed drug was ranitidine (56%). Comorbid conditions were present in 34.5% patients. In OPD and IPD 8.9% and 4.9% of drugs were fixed-dose combinations (FDCs) respectively. The mean number of drug formulations per prescriptions was 4.49±0.7 in OPD and 7.1±2.28 in IPD. Polypharmacy was prevalent in 62.5% of patients. Drugs prescribed by their generic names were 71.3% in OPD and 62.7% in IPD and 98% of were drugs that were included...
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Posted by admin on Feb 28, 2017 in |
Aim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (ointment base). Group II and III were treated with 5%w/w and 10% w/w MEZX topical ointment respectively. Group IV was treated with standard nitrofurazone ointment (0.2% w/w). The parameters recorded were percentage of wound contraction, epithelialisation period and tensile strength. Results: It was noted that the effect produced by MEZX ointment showed significant (P < 0.001) healing in all wound models when compared with the control group. All parameters such as wound contraction, epithelialisation period and tensile strength showed significant (P < 0.001) changes when compared with the control. MEZX stimulates wound contraction, decreases epithelialisation period and increases tensile strength. Conclusion: This study suggests that...
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Posted by admin on Feb 28, 2017 in |
Background: Metabolic syndrome (MetS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type2 diabetes (T2D) and cardiovascular disease (CVD). Heart fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with MetS. Methods: We measured serum H-FABP levels in 209 adult Tunisian MetS patients (108 diabetic MetS and 101 non-diabetic MetS) matched by gender and ethnic origin and 193 control subjects, using immunoturbidimetric method. All subjects underwent anthropometric and biochemical examinations. Results: Serum H-FABP levels were significantly higher in patients with MetS than in control subjects 9.80±4.75 and 3.78±1.04 ng/ml, respectively, (P<0.001). Serum H-FABP levels were significantly higher in patients with diabetic MetS than in without diabetic MetS, 12.63±4.92 and 6.77±1.80 ng/ml,...
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Posted by admin on Feb 28, 2017 in |
This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibited these Kinases Aurora B with a series of oleocanthal derivatives as legand can simultaneously induce the autophagy and apoptose in the tumoral cells. To understand the complexation mechanisms in the biological system call was made at the molecular docking, we used MOE software. was optimized geometries of all ligands, in result, the calculation of the score of energy was made to form the complex and identify the interactions in the two media a solvated (water solution) and the other unsolvated in the end we find that the ligands L5 and L6 haves the lowest...
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Posted by admin on Feb 28, 2017 in |
Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents of the leaf extracts were determined. The antioxidant activity of the extracts were investigated using DPPH, ABTS, nitric oxide scavenging assays, phosphomolybdenum assay, reducing power and metal chelating assay. Antimicrobial activity was tested against MTCC strains and MDR clinical bacteria. The antiproliferative activity was determined using MTT assay against three cancer cell lines. Results: Extracts showed high total phenolic content ranging from 85.7± 1.15 to 40.3± 0.6 gallic acid equivalents and flavonoid content ranging from 750±5.5 to 140±3.6 quercetin equivalents per gram of dry extract. Ethyl acetate extract showed highest DPPH scavenging activity with an EC50 value of 330μg/ml. The antimicrobial effects of all the extracts were found to be genus specific – only against Klebsiella spp. The chloroform...
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