Posted by admin on Oct 31, 2016 in |
The synthesis of a novel of pyrazole derivatives was achieved by condensation of acetyl furan with phenyl hydrazine to give hydrazone (1) On the other hand, cyclization of α, β-unsaturated ketone. Using Vilsmeier reagent by DMF (dimethylformamid) and POCl3 Phosphorusoxychloride) to give compound (2). The chemical structures of allnew compounds were established by IR, ¹HNMR, and mass spectra data. All the synthesized compounds were screened for in vitro antibacterial activity and most of them showed potency against both gram positive and gram negative bacteria. Compounds 4-(α-benzoyl aminoacrylic acid) – 3 – Furayl-1-phenylpyrazol, 4 – (α-benzoylaminomethylacrylate)-3-Furayl-1-phenylpyrazol, 4- (2-4-dinitrophenylhydrazone)-3-Furayl-1-phenylpyrazole showed the highest antibacterial activity against Bacillus subtilis strain with minium inhibition zone 19...
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Posted by admin on Oct 31, 2016 in |
The influence of fluconazole pre-treatment on the hypoglycaemic effect of pioglitazone (10 mg/kg, p.o) and rosiglitazone (720µg/kg, p.o) was studied. This study was conducted on diabetic rats of either sex, randomly distributed into two different groups. Diabetes was induced by administering 120mg/kg of alloxan intraperitonially. Then they were pretreated with fluconazole (36 mg/kg) in 2% w/v gum acacia suspension for seven days. On eighth day, rosiglitazone and pioglitazone were administered to respective groups one hour after fluconazole treatment. Blood samples were collected by retro orbital plexus under light ether anesthesia at different time intervals up to 24 hours. The hypoglycaemic activity of thiazolidinediones was studied and it indicated that fluconazole pretreatment has enhanced the hypoglycaemic effect of pioglitazone and rosiglitazone, at higher dose, significantly. Hence it is suggested that during the concomitant usage of fluconazole and thiazolidinediones, the therapeutic drug monitoring is essential and may also require readjusting the dose and frequency of administration of...
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Posted by admin on Oct 31, 2016 in |
The present study was carried out to evaluate oral hypoglycemic activity of rhizome of Hemidesmus indicus R.Br. in Albino wistar rats. Hemidesmus indicus (Family: Asclepiadaceae) is a commonly known Indian Medicinal Plant. It contains various phytoconstituents like hemidesminine, hemidine, hemidesmin-1 and hemidesmin-2 and other chemical constituents like glycosides, flavonoids, tannins, sterols and volatile oils. Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. Streptozotocin induced diabetic albino wistar rat by administrating graded oral doses (200 and 400 mg/kg b.wt.) injected to group 3 and 4 for 90 days. This study also includes histopathological studies of pancreas. Phytochemical screening of methanol rhizome extract of Hemidesmus indicus R.Br. The presence of alkaloids, saponins, cardiac glycosides, tannins and steroid. Metformin (100mg/kg) as standard oral hypoglycemic agent for 12 weeks resulting in significantly reduction in blood glucose. The present research work indicated that Hemidesmus indicus R.Br. methanol extract of rhizome (HIME) have prominent antidiabetic effect at a dose of...
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Posted by admin on Oct 31, 2016 in |
Diabetes is a rapid gaining status of potential epidemic in India with more than 62 million diabetic individuals currently diagnosed with the disease. Drug utilization studies are important for the optimization of drug therapy and have received a great attention in recent years. The study of drug utilization or prescribing patterns is a component of medical audit, which seeks monitoring, evaluation and necessary modifications in the prescribing practices to achieve rational and cost effective pharmacotherapy. These studies serves as a tool of investigation for clinical pharmacology and as source of suggestive information for epidemiology. The present study aimed to evaluate the drug utilization pattern of standard antidiabetic drugs in a medicine outpatient clinic of a tertiary care teaching hospital. It’s a retrospective observational epidemiological study undertaken for a period of 8 months in outpatient unit of a tertiary care Hospital, Erode. The study enrolled 175 patient prescriptions. A total of 175 patients had co-morbid conditions along with diabetes. Commonly seen co-morbid condition in the study was hypertension. The study...
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Posted by admin on Oct 31, 2016 in |
Herbal plants produce a diverse range of bioactive molecules, making them a rich source of different types of medicines. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. As such developing a polyherbal formulation will definitely produce synergistic effect as needed comparable to standard drugs that are available in market all over the world. The polyherbal formulation, which has a combination of medicinal herbs such as Allium sativum, Trigonella foenum-graecum, Linum usitatissimum was tested for its antioxidant activity, total phenolic and alkaloid contents in-vitro. The purpose of the present study was to investigate the in-vitro antioxidant, total phenolic and alkaloid content of polyherbal formulation and its application for treating life threatening diseases such as cancer, cardiac diseases, diabetes mellitus. In this paper we report the results of such studies in order to orient future investigations towards the finding of new, potent, safe and easily available food...
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