Posted by admin on Nov 30, 2016 in |
Synthesis of 6-Methyl-2, 4-dihydro-3H-pyrazol-3-one- 4- (4-substituted) Benzylpiperazine derivatives IVP a-e was carried out by bromination of Ethyl aceto acetate (I) with KBr. The reaction was carried out in the presence of Hydrochloric acid and tolune to produce Bromo-ethyl aceto acetate (II), it is further condensed with substituted Benzylpiperazines in presence of ethanol to obtain condensed compound (III). This upon cyclization with excess of hydrazine hydrate will produce title compounds. All the title compounds IVP a-e were screened for possible antibacterial activity against P. Vulgaris, S. Aureas, E. Coli, B. Subtillus and antifungal activity against Altenaria, Culvalaria, C. Albicans and A. Niger. Among the compounds synthesized IVPb and IVPc demonstrated good antibacterial activity, IVb, IVc, and IVe showed good antifungal activity. The activities of the synthesized compounds are compared with the standard and other test compounds. The structures of synthesized compounds were established by elemental analysis, IR, H NMR and Mass spectral...
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Posted by admin on Nov 30, 2016 in |
Aim: The objective of this survey was to assess the awareness pattern of analgesic administration and the various factors impacting the prescription of analgesics. Materials and methods: Pretested interviewer administered questionnaire was distributed to 100 study subjects consisting of post graduates and dental practitioners in Chennai. The questionnaire was designed to contain questions regarding the most commonly prescribed analgesic in various dental procedures and the various factors taken into account by the dentist while prescribing these analgesic drugs. The data was analysed using SPSS software. Results: In this study, the most commonly prescribed analgesic was paracetamol (78%). 63 % of the dentists preferred non-opioids, 28% preferred opioids and the remaining 9% prescribed both opioids and non-opioids.87% of the dentists have chosen combinations of analgesics. The most commonly prescribed combination was paracetamol with diclofenac(59%). 83% of the dentists preferred topical analgesics. 94% of the dentists took into account, the medical condition of the patient while prescribing analgesics. Special care for pediatric patients was given by 97% of the dentists. Among...
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Posted by admin on Nov 30, 2016 in |
This study was designed to determine the extent of photolytic degradation of diazepam tablets, without light-protective packaging, available in the market. The UV spectroscopy method was designed and applied for this purpose. A total of 2160 tablets (each tablet contained 5 mg diazepam) of three different brand formulations A, B and C were chosen randomly. These tablets were then exposed to different indirect and direct lighting conditions i.e. normal room light condition (for 60 days), direct sunlight exposure (6 hours per day for 3 days), 25 Watt incandescent light bulb exposure and 40 Watt incandescent light bulb exposure (6 hours per day for 3 days). Samples from these light exposures were analyzed for potency determination using UV spectrophotometer and compared against the tablets kept in dark place (Control). Tablets of all three formulations showed marked degradation. The overall average degradations were 23.64%±5.53%; 28.36%±4.87%; 19.72%±4.83% and 25.40%±4.17% respectively for normal room light, direct sunlight, 25 Watt and 40 Watt incandescent bulbs whereas tablets kept in dark place showed little or...
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Posted by admin on Nov 30, 2016 in |
A simple, rapid, sensitive, and accurate high performance liquid chromatography was developed for determination of Idelalisib (IL) in rabbit plasma using Ibrutinib as internal standard (IS). Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). The analytes and IS were separated on a ODS (250 mm × 4.6 mm, 5 µm) column using Mobile phase composition as Buffer and Acetonitrile in the ratio of 85:15 v/v%. The total chromatographic runtime is 10.0 min with retention time for IL and IS at 7.195, and 5.435 min, respectively with a flow rate 1ml/min. The method is validated over a dynamic linear range of 0.02-4 µg/mL for IL with a correlation coefficient of r2 0.999. The method was validated as per the USFDA guidelines and the results were within the acceptance criteria for selectivity, sensitivity, linearity, precision, accuracy, recovery stability of solution and stability of solution in...
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Posted by admin on Nov 30, 2016 in |
Phoenix sylvestris Roxb, commonly known as date sugar palm or wild date palm, grows naturally in the tropics and subtropics of the Indian subcontinent. The present study was aimed for phytochemical evaluation and to develop the high performance thin layer chromatography (HPTLC) fingerprint profile of methanolic extract of P. sylvestris at two ripening stages. The powdered plant material was extracted using methanol. Quantitative analysis of phytochemicals and HPTLC fingerprinting analysis were carried out. The quantitative analysis of the phytochemicals revealed the presence of various amounts of total phenolic, total flavonoids and total tannins. These phytochemicals were significantly higher in the unripened stage than ripened stage. The HPTLC fingerprinting analysis was carried for phenolic compounds by using Camag Linomat 5 instrument which revealed the presence of phenolic compounds in two stages of P. sylvestris. HPTLC data revealed that unripened extract has high quality phytochemicals than ripened extract. The phytochemical changes of P. sylvestris fruit ripening clearly explained its growth, development and ripening...
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