Posted by admin on Nov 4, 2016 in |
Stress is part and parcel of our life and stress management is gaining importance day by day. Traditional mantras are reported to be very effective for and safe methods. Hence the traditional knowledge of mantras should be practiced, preserved and propagated. Om Namah Shivaya is a most potent and popular mantra, which is at the heart of the Vedas and Tantra. The present study was aimed to observe beneficial effects of OM Namah Shivaya chanting for stress management in elderly women with hypertension. The study was conducted at Sattva Cultural Space and Research Centre, Angamaly, Kerala. 8 elderly women aged 55-65 years with stage 2 hypertension were recruited in the present study after obtaining written informed consent. After recording baseline values, participants underwent practice sessions for 3 days under supervision of yoga teacher from the centre. After the practice sessions, participants chanted Om Namah Shivaya for 108 times by using japamala with 108 beds at 6;30 in the morning for 40 days under supervision of yoga teacher. Participants were...
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Posted by admin on Oct 31, 2016 in |
In chronic alcoholics, continuous heavy drinking leads to progression of alcoholic liver disease (ALD) from alcoholic fatty liver, hepatitis to cirrhosis. Strict abstinence from alcohol has its own limitations and there is paucity of promising drugs available to treat ALD. Malotilate showed promising hepatocyte regenerating capacity and ability to prevent such damage. Aims: The objective of this study was to evaluate curative effect of malotilate on ALD in rats. Methods: The study was done using Sprague Dawley rats. 5 groups were treated as: 1. Control: ethanol 40% v/v (orally 1ml / 100 g / d), 2. Vehicle control: Methyl Cellulose and 3, 4, 5: malotilate, three doses 25 (Low), 50 (Moderate), 100 (High) mg /kg / d orally, respectively. In all groups: ethanol was given initially for 21 days. Then vehicle or malotilate was administered for next 21 days. The liver damage was assessed bio-chemically on day-1, day-22, day-43 by measuring serum AST, ALT, ALP, GGT, total bilirubin, direct bilirubin, total protein, albumin and prothrombin time. The histo-pathological assessment...
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Posted by admin on Oct 31, 2016 in |
Pharmacokinetic modeling is the representation of the logarithmic mathematical equations in order to measure the physiologic response of the body to the drug. Absorption, distribution, metabolism and excretion follow drug kinetic principles according to specific reaction mechanisms in which concentration of the drug may either be dependent or independent of drug-body interactions. Michaelis-Menten equation exhibits association between drug concentration and its mass transfer through a kinetics transport mechanism, a principle also known as Fick’s Law of Diffusion. Reaction orders are the sum of the powers of drug concentrations being raised to a certain degree that follows a certain pattern of drug kinetics according to rate laws being established. Reactions between the drug and the body usually follows first and second order rate. First order rate of reaction can be described as drug concentration dependent, whereas, zero order reaction rate can be explained as drug concentration independent. This paper aims to describe the derivation of pharmacokinetic principles acting in multi-compartment model as the drug enters and exits the body using...
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Posted by admin on Oct 31, 2016 in |
Aim: Dalton’s Lymphoma Ascites cells (DLA) are a cancer of the lymphocytes, a type of cell that forms part of the immune system. The present study aims to evaluate the anticancer effect of methanolic extract of bokchoy (Brassica rapa Chinensis leaves) using in vivo model in mice. Methods: The experimental mice were divided to 5 groups. The methanolic extract (800 mg/kg) and nanoparticles of methanolic extract (1mg/kg) of Brassica rapa Chinensis leaves, was administered to mice of group III and IV respectively. The mice were induced with DLA. Group I mice served as normal control and group II as DLA control. Cyclophosphamide at 3mg/kg b.wt was administered to group V. Results: Treatment with methanolic extract and nanoparticles of methanolic extract of Brassica rapa Chinensis leaves (800, 1mg/kg, orally) against Dalton’s Lymphoma Ascites (DLA) in mice by the activities of marker enzymes as Aspartate transaminase (AST), Alanine transaminase (ALT), Alkanine phosphatase (ALP), Acid phosphatase (ACP), Lactate dehydrogenase (LDH), γ Glutamyl transpeptidase (γGT), 5’Nucleotidase, β-D-Glucuronidase, β-D-Galactosidase and Cathepsin D levels in...
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Posted by admin on Oct 31, 2016 in |
The study was aimed to investigate the common causative agents of urinary tract infection in community, their resistance pattern to different antibiotics, and the prescribing patterns of antibiotics used for treatment. A total of 200 women attending gynaecology OPD of Tribhuvan University teaching hospital had their urine tested for culture and sensitivity, out of which 85 showed microbial growths. Escherichia coli (56.9%) and Staphylococcus aureus (27.7%) were the most common organisms isolated. E.coli was found to be resistant against ampicillin (72.7%), followed bycephalexin (59.3%), cotrimoxazole (45.2%), cefixime (40%), ceftriaxone (26.3%), norfloxacin (25.9), ciprofloxacin (25%), ofloxacin (20.7%) nitrofurantoin(9.7%), gentamycin (9.4%) and amikacin (8%). S.aureus was found to be resistant against cefixime (71.4%), followed by ampicillin (64.7%), ciprofloxacin (60%), cotrimoxazole (35.7%), ofloxacin (33.3%), norfloxacin (33.3%), cephalexin (23.5%), cloxacillin (17.6%), gentamycin (8.3%) and nitrofurantoin (5.9%). Out of 65 patients, 48 were treated with definite antibiotic therapy and 17 were treated with empirical antibiotics. The antibiotics used in definite therapy were nitrofurantoin (36.7%), ofloxacin (20.4%), cephalexin (10.2%), norfloxacin (8.2%), ciprofloxacin (8.2%), cloxacillin (4.1%),...
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