Posted by admin on Aug 31, 2016 in |
Flouroquinolones (FQ) used commonly for treatment of community and hospital-acquired infections, has been prefixed with multiple adverse effects. Amongst them the glycemic variability has been attention seeking. Drug induced dysglycemia can be acute or persistent and severe too. The present study is designed to evaluate and compare the actions of Levofloxacin vs. Norfloxacin in altering blood glucose levels in Alloxan induced diabetic albino rats. 30 albino rats with fasting blood sugar (FBS) in the range of 80-115 mg/dl were induced diabetes with intraperitoneal Alloxan (150mg/kg body wt). After 7 days of induction, the rats that developed a stable hyperglycemia with FBS≥250 mg/dl were selected for the study. Following administration of test and standard drug FBS levels were measured on days 0, 3, 7, 14 & 28 using glucometer. Statistically, values in all the groups were analyzed by using one-way analysis of variance (ANOVA), followed by independent T test for group comparisons. P values less than 5% (0.05) was considered as significant. Glycemic variation was found to be statistically significant...
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Posted by admin on Aug 31, 2016 in |
Background-In September 2012, the world health organization reported a global prevalence of diabetes exceeding 300 million people, predicting a further 60-70% increase by the year 2030, which means India alone will have 100 million people by year 2030. Wound healing is problematic in diabetic patients. Encouraging results have shown that PDGF application is better than good wound care alone. But the evidence to demonstrate the safety and efficacy of PDGF in Diabetic ulcer is scanty. Aim-To Study the Efficacy of Platelet Derived Growth Factor in Diabetic Lower Extremity Ulcer. Methods-This study was a prospective, double blind, and placebo controlled study. A total of 29 patients with 35 ulcers were included and divided in case and control group. The study medication was administered in conjunction with standardized good wound care for 24 weeks or until target ulcer healed. Results-It was found that 74.2% of ulcers were neuropathic while 48.3% patients had foot deformity in this study. At the end of 24 weeks 100% ulcers in group receiving PDGF completely healed...
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Posted by admin on Aug 31, 2016 in |
Introduction: Blood is the only oxygen transporter in the body and is crucial in saving lives. Research has failed to find a true substitute for blood and blood components The attitude, beliefs, and level of knowledge associated with blood donation will determine whether potential donors will donate blood or not. Methodology: A descriptive epidemiological study with cross sectional study design was conducted among blood donors attending the blood bank of SSKM Hospital. Result: It was found 67.08% of the donors had a knowledge score of less than 5. It was found that donors from urban areas, higher educational and socio-economic status as well as those who had previous history of blood donation had higher knowledge scores. This was statistically significant (p<0.05). Mass media like television and radio had an insignificant role in creating awareness as only 5% and 2% of the donors were made aware through these respectively. The most important source of knowledge for the donors was blood donation camps as an overwhelming 68% were made aware through...
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Posted by admin on Aug 31, 2016 in |
Diabetes Mellitus (DM) has emerged as a common endocrine disorder in the world and the prevalence of thyroid dysfunction is increasing at the same time. The thyroid hormones control insulin secretion. In hypothyroidism there is a reduction in glucose-induced insulin secretion by beta cells, and during thyrotoxicosis the insulin resistance will be increased. Type 2 diabetes mellitus patients with subclinical hypothyroidism are at risk of complications like neuropathy and cardiovascular events. Hence, there is a need to detect subclinical hypothyroidism in diabetic patients.50 type II DM patients were screened for thyroid function studies viz T3, T4 & TSH. 50 age and sex matched healthy volunteers were treated as controls and the results were correlated with fasting blood glucose levels and lipid parameters. The results showed a significant difference among the controls and the patients. It may be concluded from this study that there is hypothyroidsm in DM...
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Posted by admin on Aug 31, 2016 in |
Red blood cells (RBCs) is the primary target of human Plasmodium. Species. Occurs oxidative stress on uninfected and infected RBC and lead to hemoglobin (Hb) level decreased. The mechanism of decreased hemoglobin level are reduced survival time, diserythropoiesis and increased erythrolysis. Ascorbic acid and phenolics of TCW effectives to prevent RBCs from oxidative damage. Methods: The post test only randomized control group desain in 30 Swiss mices inoculated with PbA separated in 2 control groups K(+) and K(+)DHP, 4 groups of treatment X1, X2, X3 and X4. TCW treatments of 1mL and 2mL per 100g BW. Statistical analysis uses for parasitemia index and Hb levels was one way ANOVA test. Correlation of both variabel analyzed using Pearson’s test. Results: There were differences of the parasitaemia index (p<0.05) and mean±SD (%) K(+) (20.46±9.43), K(+)DHP (0.28±0.33), X1 (14.86±5.82), X2 (1.26±1.94), X3 (4.40±1.45) and X4 (0.32±0.40). There were significant differences in Hb levels (p<0.05) and mean±SD (g%)(8.46±1.36, 11.92±1.16, 9.92±1.77, 11.04±1.92, 11.06±0.80 and 12.80±1.16), multiple range test shown the differences of K(+) againts...
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