Posted by admin on Sep 30, 2016 in |
Tuberculosis (TB) remains a highly significant infection of microbial origin causing death of human in developing countries. The anti-tubercular drugs are less effective because of the emergence of multi-drug resistant strains and ineffective to extensively drug resistant strains of Mycobacterium tuberculosis. Plants are being an alternative source of anti-microbial compounds; the aim of this study was to investigate anti-mycobacterial potential of the few Indian medicinal plants and isolated compound from these to standard avirulent Mycobacterium tuberculosis H37Ra, standard virulent H37Rv and isoniazid resistant clinical isolates using Broth Microdilution Method. Methods and Results: Lyophilised ethanolic, aqueous and aqueous ethanolic extracts of four Indian medicinal plants viz. Coleus amboinicus, Glychirrhiza glabra, Pongamia pinnata and Terminalia chebula were screened for their in vitro antimycobacterial activity by Broth microdilution method (BMM) after 14 days of incubation at 37°C. The ethanolic extract of G. glabra was active against the tested strains of M. tuberculosis in primary screening with a MIC of 500µg/ml. The other extracts failed to exhibit inhibition at the tested concentrations. Glycyrrhizin...
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Posted by admin on Sep 30, 2016 in |
The natural acid like lemon juice provides mild acidic state which used to catalyzed reaction of primary amine and aldehyde in green solvent like ethanol at room temperature reflux for 1.5 hour gives Schiff bases in good yield. Schiff bases have attracted considerable attention of us due to their significant biological activities 1 like anticancer, antitumor, anti inflammatory agents 4, insecticidal, antibacterial 5, antituberculosis, antimicrobial 2-3, antifungal 5, anti-HIV and metal corrosion inhibition activities of Schiff bases, besides wide range of pharmacological activities. Natural acid is non-polluting and does not employ any lethal materials, quantifying if as a green approach for the synthesis of Schiff bases. Schiff bases also have several types of biological actions such as analgesic and antimalerial 6. They are working as Ligands for complexes of metal ions. Organosilicon complexes with Schiff bases are found to be beneficial in various agricultural applications like fungicides, bactericides, herbicides, acaricides and antifeedants 7. The metal complex of Schiff bases are also of principal significance in analytical chemistry and chemotherapy...
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Posted by admin on Sep 30, 2016 in |
Biofunctionalization of nanoparticles is an advancement of current nanotechnology and biotechnology fields. Developing biocompatible progressive functional materials possess antimicrobial properties could be hopeful for environmentally benevolent applications. Biofunctionalization of nanomaterials is one such topic to produce the non-toxic and more efficient antimicrobial agents. The present study describes a synthesis method of bioactive curcuminaniline functionalized zinc oxide nanoparticles in the eco-friendly methods and comparative studies of those were undertaken against non-functionalized zinc oxide nanoparticles. The synthesis process was carried out through a simple green methodology. Synthesized nanoparticles were analyzed for antibacterial activity by using disc diffusion method against two gram-positive bacteria and two gram-negative bacteria and antifungal activity by using agar well diffusion method against four funguses. Synthesized materials were characterized by UV- Vis, FT-IR, SEM and TEM techniques. The synthesized zinc oxide nanoparticles were in the range of 46 nm and the biofunctonalized nanoparticles were about 100 nm. The antimicrobial activities of those were showed appreciable inhibition zones against S.typhi, B.subtilis, A.niger and T.simii...
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Posted by admin on Sep 30, 2016 in |
Aim of the present study was to compare antianxiety activity of various extracts of Oats (OA), Rice Bran (RB) and Spinach (SP) which are rich in phenolics mainly flavonoids and possesses excellent antioxidant property. Flavonoids are reported to have effect on central nervous system, mainly in anxiety disorders. The activity of various extracts (petroleum ether and hydroalcoholic) of all the three plants was evaluated at different doses (50, 100, 200 mg/kg of body weight) using EPM model of anxiety. The studies were conducted on swiss albino mice, and the test materials were administered per oral route. Results indicated that out of all the prepared extracts of the three selected plants, hydroalcoholic extract of Spinach (Spinacia oleracea) exhibited maximum and significant effect at 200 mg/kg of body weight, the results were comparable to the standard antianxiety drug diazepam (2 mg/kg...
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Posted by admin on Sep 30, 2016 in |
Fexofenadine Hydrochloride (FHCl) is a second generation antihistaminic drug which is used in the treatment of allergic rhinitis and urticaria. It is a BCS class II drug and has high first pass metabolism leading to low oral bioavailability. Drug-inclusion complex with 2HPβCD was prepared by kneading method and characterized for solubility study, FTIR study and in vitro dissolution study. Nine different combinations of polymers to be added were generated by Central Composite Design was used to evaluate dependent parameters by varying the independent variables, HPMC E5 and HPMC K4M and responses were tensile strength, mucoadhesive strength and in vitro diffusion. Films were prepared and evaluated for different parameters and found to be in acceptable limits. Optimized formulation F10 generated from the design showed good tensile strength and mucoadhesive strength and optimum in vitro diffusion results. Drug permeation through porcine oral mucosa at the end of 120 mins was 85.59%. Short term stability studies revealed that formulation was stable after storage for 1...
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