Posted by admin on Sep 30, 2016 in |
Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan Cilexitil is approximately 15% after an oral administration. To increase bioavailability of such drug, solubility and dissolution are important parameters. To increase solubility of candesartan cilexitil, spray drying technique was incorporated with use of Fluidised Bed Processor. Also dissolution rate was improved with the use of appropriate superdisintegrants. Superdisintegrants used are Croscarmellose sodium, Crospovidone and Sodium starch glycolate. Dissolution rate of Candesartan Cilexitil from prepared dispersible tablet was compared with marketed formulation. Results have shown that solubility of Candesartan Cilexitil has been increased and dissolution rate was improved significantly. The transformation of Candesartan Cilexitil from crystalline to amorphous state by spray drying and the use of superdisintegrants are considered among the factors which...
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Posted by admin on Sep 30, 2016 in |
Asteracantha longifolia, Asparagus falcatus, Vetiveria zizanioides, Coriandrum sativum and Epaltes divaricate have proven hepatoprotective and antioxidative effects against carbon tetrachloride and paracetamol induced hepatotoxicity in mice and are widely used in Sri Lanka for the treatment of liver disorders. However, toxicological information regarding their safety after exposure to experimental animals or humans is not available. The present study was designed to evaluate repeated dose toxicity of the five aqueous extracts mentioned above. Healthy, ICR mice were treated with 0.9g/kg (orally) of aqueous extracts daily, for a period of 30 days. Animals were observed for effects on body weight, food consumption, external appearance and mortality. Biochemical, haematological and histopathological parameters were estimated in all groups at the end of 30 days. Aqueous extracts tested didn’t produce mortality, changes in behaviour, difference in body weight, feeding habits or any other physiological activities in mice, at the dose administered. Biochemical or haematological analysis showed no marked differences in any of the parameters examined in either the control group or in the plant...
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Posted by admin on Sep 30, 2016 in |
The Tablet manufacturing process is a complex process, influenced by several process variables The aim of this study was to optimize blending; roller compaction and tablets compression processes using design space approach for a model Anti- Hyperlipidemic drug Fluvastatin. During each processes there are several factors which may affect product quality. So the main objective of present work was to identify various parameters and optimize the parameter for formulation of better product which includes Blending time, Roller force, Compression force and machine speed which were recognized as critical process parameters and were evaluated. A scale up batch is taken to evaluate and optimize the parameters. Critical quality attributes like Blend uniformity, granules parameters, flow behavior, tablet appearance, impact on tablet physical parameters and in-vitro drug dissolution release profile is evaluated to optimize the parameters. The data & test results of blend, granules and tablets at various in-process phases were complied with the specified limits and finished product sample analysis results found to be complying within specifications. This study and...
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Posted by admin on Sep 30, 2016 in |
Coccinia grandis (Linn.) Voigt (Cucurbitaceae) has been widely used for the management of diabetes mellitus in Sri Lankan traditional medicine. The aim of the present study was to investigate antihyperlipidemic, antioxidative effects of the leaf extract of C. grandis in sterptozotocin induced diabetic rats and to standardize the leaf extract of C. grandis by standard analytical methods. The results showed that the concentration of serum total cholesterol, triglycerides and low density lipoprotein cholesterol were significantly lower in C. grandis (0.75 g/kg) treated rats than in diabetic control rats (P < 0.05). In addition, an improvement in the antioxidant potential is also showed in C. grandis treated diabetic rats. P < 0.05). The polyphenolic compounds, alkaloids flavonoids, saponins and sterols/tritepenoids were present in the C. grandis extract. The results revealed that the aqueous leaf extract of C. grandis (0.75 g/kg) exerted antihyperlipidemic and antioxidative effects in diabetic rats, corroborating the therapeutic use of C. grandis leaf extract in the management of diabetic complications in traditional...
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Posted by admin on Sep 30, 2016 in |
Background and Aim: Valproic acid (VPA) is a widely used antiepileptic drug. The main pathway of its elimination is through conjugation by UDP-glucuronosyltransferases with several polymorphic forms. In this study, we aimed to examine the effect of polymorphism in UGT1A6 enzyme-coding gene at two loci, namely, 541A>G and 552A>C on clinical outcome in Egyptian children with idiopathic epilepsy. Clinical outcome investigations involved VPA serum level, seizure control and incidence of adverse drug reactions (ADR). Methods: Genetic polymorphisms were detected in 48 patients receiving VPA monotherapy by PCR-RFLP. Steady state concentrations at trough level were determined by homogenous enzyme immunoassay technique. Patients were monitored for ADR, seizure frequency as well as seizure severity (SS). Results: Variant genotype group (AC & CC) had lower concentration to dose ratios (CDR) than those with (AA) genotype for UGT1A6 552A>C (p=0.029). Variant allele carriers had significantly lower CDR than wild allele carriers for both 541A>G and 552A>C (p= 0.047 and p= 0.001, respectively). Wild genotype for 552A>C had higher SS scores on Chalfont scale...
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