Posted by admin on Jul 31, 2016 in |
Azima tetracantha is a small flowering shrub belongs to salvadoraceae family and commonly known as mulluchangu or mulsangu in Tamil. It is an best known medicinal plant ,which have a central role in the treatment of disease from pre historical period. From the plant lot of phytochemicals has been reported such as alkaloids, steroids ,tannins, terpenoids, flavonoids, glycosides, phenols etc and also possesses activities such as antioxidant, antifungal, antibacterial , hepatoprotective, antidiabetic and antihyperlipidemic etc .In the present study preliminary evaluation and isolation of an active pharmacological compound euphol was obtained from the chloroform extract of the leaves of Azima tetracantha was carried out. The compound euphol is a tetracyclic triterpene alcohol which produces antinociceptive effects in inflammatory and neuropathic pain. The compound was isolated by column chromatography and characterized by chemical test, TLC, FTIR, NMR, C 13 NMR spectrum. In future it may be a promising molecule for the management of neuropathic...
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Posted by admin on Jul 31, 2016 in |
The Wheat, Maize and Cotton are the major crops in the agriculture field specially in Maharashtra, India. So for better productivity this study aims to prepare steam soluble aroma compounds called hydrosols. Hydrosols of different plant species (Ipomea carnea Leaves and Flowers, Lantana Camera Leaves) were prepared by steam distillation method. The purpose of this study was to determine the effect on the growth of Wheat, Maize and Cotton crops by using Ipomea carnea leaves and flowers and Lantena camera leaves. In this study the wheat, maize and cotton crops were germinated in different pots and continuous dosing of hydrosol was applied with fixed quantity and result was observed after...
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Posted by admin on Jul 21, 2016 in |
Advances in nanoparticulate frameworks for enhanced medication conveyance show an extraordinary potential for the organization of urgent dynamic particles. The fundamental motivation behind creating elective medication conveyance advances is to build proficiency of medication conveyance. Pterospermum acerifolium is normal plant in India is viewed as carminative, stimulant and emmenagogue. The point of this study was to figure another conveyance framework for impacts of neurobehavioural by the joining of concentrate of Pterospermum acerifolium into strong lipid nanoparticles SLN. SLN plans were set up by ethanolic extricate implanted lipid layer was softened by warming at 5°C above liquefying purpose of the lipid. After that, SLNs were sifted and dried .Shape and surface morphology of the strong lipid nanoparticles were envisioned by filtering electron microscopy (SEM).Particle Size and Size Distribution were dictated by Photon relationship spectroscopy (PCS). The change of molecule charge was considered by Zeta Potential (ZP) estimations. The CNS action was examined in a few test models for Epilepsy i.e. Limit Pentylenetetrazole prompted seizure, Models for anxiolytic study i.e. Hoisted...
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Posted by admin on Jul 9, 2016 in |
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study was to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric bioanalytical method for the estimation of candesartan in pure form. For the estimation of candesartan, solvent system employed was absolute methanol and wavelength of detection (λdet) was 268.8 nm for first order derivative spectroscopy. The linearity was obtained in the range 2 – 10 µg/ml with a regression coefficient of R2 = 1. The limit of detection is 0.99 µg/ml and limit of quantification was found to be 3.1 µg/ml. Obtained results showed that there is minimum intraday and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and...
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Posted by admin on Jun 30, 2016 in |
Due to the increasingly tight controls around compliance, pharmaceutical firms continue to seek more efficient ways to track, document and report on code changes in regulated applications such as those developed for managing samples and inventory. Such applications and electronic signatures associated with application development and workflows are subject to stringent regulations such as Sarbanes-Oxley Act (SOX), in addition to related audits. The pharmaceutical industry is in a state of flux, and the increasing regulations are making their job even more challenging! One of the outcomes of the introduction of the Sarbanes-Oxley Act focused organizations toward compliance and controlling changes in their environment. This adherence to compliance helped to stabilize environments to some extent and organizations spent a lot of money and energy into becoming compliant and putting controls into place. Every change introduced to the system has the ability to “break” the system. The amount of changes and the speed at which change is introduced is directly proportional to disruptions in service and downtime. As the pharmaceutical environment...
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