Posted by admin on Jun 30, 2016 in |
The aim of the study was to determine the anticonvulsant activity of methanolic extract of Lawsonia inermis leaves in albino rats. The anticonvulsant activity of methanolic extract of leaves of Lawsonia inermis (200 mg/kg and 400 mg/kg) was assessed in rats using maximum electroshock seizure (MES) test and pentylenetetrazole (PTZ) induced seizure test. The methanolic extract of Lawsonia inermis leaves significantly (p<0.01) reduced the hind limb tonic extension in the MES test in a dose dependent manner. In the PTZ model also, the extract signicantly (p<0.01) reduced the duration of clonic convulsions as well as delay the onset of seizures in a dose dependent manner. The study demonstrates that Lawsonia inermis has significant anticonvulsant activity possibly through a GABA-ergic...
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Posted by admin on Jun 30, 2016 in |
Purpose: Neonatal sepsis, a major killer among neonate, necessitates urgent implementation of empirical therapy and later specific antimicrobial therapy against causative microorganism. Empirical therapy relies upon data obtained from previous studies. We conducted this study to evaluate the blood culture, sensitivity and resistance pattern of various antimicrobial agents in neonatal sepsis at Neonatal Intensive Care Unit at a tertiary care hospital in western part of India, which will show us the changing pattern of etiological organism and antimicrobials needed to curb them. Methods: We conducted a prospective cross sectional study over a period of six month duration in Neonatal Intensive Care Unit at tertiary care hospital. We collected and analyzed the blood culture reports and sensitivity pattern of antimicrobials used. Results: We enrolled 163 patients of neonatal sepsis. Paediatricians sent 163 blood samples for culture of which 62 % culture were positive. Out of 101 positive cultures 70 % were Gram negative organisms. Most frequently encountered organisms were Klebsiella Pneumonia followed by Acinobacter species while least common was Coagulase...
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Posted by admin on Jun 30, 2016 in |
Biofilm formation is prevailing in almost all bacteria. They are responsible to cause infections like Peritonitis, Cystic fibrosis, Endocarditis, Otitis media, UTIs. The infections caused by the biofilms forming bacteria that colonize the indwelling medical devices are a major source of patient morbidity and implant failure. The study on biofilm formation on indwelling medical devices is important from a public health perspective. In the present study we have isolated various organisms on indwelling medical devices, and tested them for biofilm formation and also antibiotic susceptibility. In the present study a total of 100 isolates are identified by standard microbiological procedures, evaluated for biofilm production from various indwelling medical devices by two different methods, Tube method and by using Congo red agar. The Results 48% of isolates showed biofilms production, Klebsiella being the predominant isolate 20 (42%). Gram negative isolates were sensitive to Amikacin and Nitrofurantoin 22 (46%). Gram positive isolates were sensitive to Vancomycin and tetracycline 11 (23%). Congo red agar method was considered to be superior to test...
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Posted by admin on Jun 30, 2016 in |
Introduction: Utilization of skilled health care is effective in reduction of maternal and newborn morbidity and mortality. Sufficiently trained health workers can competently handle and manage obstetric complications. Health workers, despite having undergone a formal training, require regular refreshers to keep up to date with new, evidence-based information. Methods: This is an evaluation report following Emergency Obstetrics and Neonatal Care skills – based training by Maternal and Infant Survival and Healthcare Advancement (MAISHA), a project by Dedan Kimathi University of Technology and College of The Rockies, Canada in collaboration with Liverpool School of Tropical Medicine and the Ministry of Health among health care workers in Migori and Nyeri Counties’ health facilities. Knowledge and skills pre-test was done before the training and a similar post-test was administered after the training to assess the level of knowledge and skills of each participant. Follow up was done to the trained participants four months after the training to assess the level of retention of the skills. Findings: The pre-test findings indicated that the...
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Posted by admin on Jun 30, 2016 in |
Colorants are mainly used to impart a distinctive appearance to the pharmaceutical dosage forms. The present study was carried out to develop aluminium lake color of a dye obtained from black carrot using different adsorbents (Aluminium oxide or aluminium hydroxide) in different ratio by simply mixing them to get dye adsorbed onto the surface of adsorbent. Adsorption experiment was carried out for 60 minutes. Aluminium oxide at a concentration level of 30% w/v found to be the choice of adsorbent after optimization because maximum adsorption of dye from reaction mixture after 60 minutes and maximum % yield. After optimization of adsorbent the effect of pH and temperature also studied by formulating lake by varying these two parameters. It was observed that a higher temperature (50oC) and a lower pH (3) favor the adsorption. The lake then characterized for various physicochemical properties like angle of repose, Carr’s index, hausner’s ratio, loss on drying, particle size and limit test for heavy metals. The lake was found to follow pseudo second order...
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