Posted by admin on Aug 31, 2016 in |
The antioxidant and anti-inflammatory activities of various solvent extracts of Fomitopsis dochmius, a polypore found in Western Ghats of Kerala, India were investigated. Petroleum ether (PE), ethyl acetate (EA), 70 % aqueous ethanol (ETH) and hot water (AQ) extracts of the fruiting bodies of the mushroom were examined for their antioxidant activities. PE was found to show activity against hydroxyl radicals, lipid peroxidation and ABTS.+ radicals. EA extract was able to scavenge DPPH., hydroxyl, and ABTS.+ radicals and also showed ferric ion reducing and lipid peroxidation inhibition properties. ETH and AQ extracts were active against all the above mentioned radicals besides superoxide and nitric oxide radicals. Since ETH extract showed higher antioxidant activity than other solvent extracts, its anti-inflammatory property was examined. The extract, at a dose of 500 mg/ kg body weight, was found as effective as the standard anti-inflammatory drug diclofenac (10 mg/ kg body weight). The preliminary phytochemical analysis of the four extracts indicated that the fruiting body of the mushroom contained steroids, terpenes, coumarins, phenols,...
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Posted by admin on Aug 31, 2016 in |
Very little knowledge about use of papaya leaves is available in the literature, the leaves of papaya are bitter to taste which explains its therapeutic benefits. The present study was undertaken to assess anti diabetic effects of leaves extracts of Carica Papaya and Glucophage on streptozotocin –induced diabetic mice. Results indicates that hyperglycemic level in diabetic mice was normalized after administration of various doses (50, 150 and 300 mg/kg bw) of ethanolic leaves extracts to diabetic mice. Similarly leaves extracts of C. Papaya have also shown pronounced effects on plasma insulin, triglyceride, cholesterol and HDL cholesterol levels. The levels of liver enzymes (ALT, AST and ALP), bilirubin and blood cells (Red cells, white cells and platelets) were improved on dose depended manner. Analysis of various leaves extracts for phytochemicals revealed presence of significant amount of alkaloids, steroid, tannins, total phenols and flavonoids. It is assumed that biologically active components of papaya leaf extracts are helpful in decreasing secondary complications of diabetes and improved insulin sensitivity to uptake glucose by...
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Posted by admin on Aug 31, 2016 in |
Enhanced production of anthraquinones from cell suspension cultures of Oldenlandia umbellata were established through elicitor or precursor treatment. Stock cell suspension cultures were developed in liquid MS medium supplemented with 2.5 µM NAA using friable calli. Standardization experiments of suspension cultures revealed that 10 µM NAA added liquid MS medium was optimum for the growth and AQ accumulation from O. umbellata suspension cultures. 10 µM NAA produced 9.96 mg g -1dw AQ on 30th day of incubation. Later enhanced AQ production was achieved by the addition of elicitors or precursors into the standardized media on 25th day of incubation and AQ quantification was done after 5 days of incubation. Addition of elicitors or precursors resulted in a sudden increase in AQ content. 25 mg L-1 pectinadded suspension cultures produced 35.67 mg g-1dw AQ and precursor feeding with 50 mg L-1α-keto glutaric acid resulted in the accumulation of 42.63 mg g-1dw AQ. HPLC analysis of elicitor or precursor mediated suspension cultures revealed the presence of alizarin and purpurin in samples....
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Posted by admin on Aug 31, 2016 in |
Two chalcone diols (2E)-1-(4-hydroxyphenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one and (2E)-1-(4-hydroxy-3-methoxy phenyl)-3(4-hydroxy, 3-ethoxy phenyl) prop-en-1-one were synthesized by acid catalyzed ClaisenSchmidt reaction. The synthesized chalcones were made to undergo polymerization using three aliphatic dichlorides namely glutaryl, succinyl and oxalyl chlorides. The polymers were random copolyesters and characterized by solubility and viscosity measurement. The structure of the copolyester was established by FTIR, 1H-NMR and 13C-NMR. The biocidal efficacy was done by Disc diffusion method and found to be nominal against the standards used. Thus these copolyesters may be considered as drug...
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Posted by admin on Aug 31, 2016 in |
Two new oleanane triterpene type saponins named lebbeckanin I (1) and lebbeckanin II (2), in addition to a new isomer of methyl inositol, D-1-O-methyl-cis-inositol (3), were isolated from butanol fraction of Albizia lebbeck (L.) Benth flowers. Their structures were established on the basis of spectroscopic analysis including MS, 1H & 13C NMR, 1H-1H COSY, HSQC & HMBC. The fraction containing mixture of compounds 1 and 2 exhibited significant cytotoxic activity against HePG-2 (Hepatocarcinoma), HEP-2 (Larynx carcinoma), HELA (Cervical carcinoma), MCF-7 (Breast carcinoma) and HCT-116 (Colon carcinoma) cell lines with LD50 values of 1.74, 3.42, 4.29, 0.65 and 0.74 µg respectively. In addition, the antimicrobial screening of the same fraction was evaluated and showed variable degrees of activity against all the tested organisms. It is notable that the same fraction showed antifungal activity against Syncephalastrum racemosum (RCBM 05922) stronger than that exhibited by Amphotericin...
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