Posted by admin on Mar 31, 2024 in |
Introduction: Distal femoral fractures are among challenging orthopaedic injury constituting 0.4% of all fractures. Despite recent evaluation in operating techniques and surgical implants, debate continues around the choice of implant for various type of distal femur fractures. Method and Material: In prospective randomized study from 2020 to 2022, analysis of 40 patients was done out of which 20 cases were treated in each group with follow-up at 2,6,12,24 weeks and 6 months. Results: Clinical and radiographic evaluation according to KOOS functional score demonstrated that in RL group, 3 case were excellent, 10 cases were good, 07 cases were fair, while in LP group: 01 case was excellent, 07 cases were Good and 11 cases were fair and 01 case was poor. Over 90% of fractures under RN and LP healed within 6 months with average time being 21.15 weeks (range 12 to 28 weeks) in RN and 23.30 weeks (range 12-32 weeks) in LP group. Out of 20 cases of RN group, 2 went for delayed union requiring dynamisation...
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Posted by admin on Feb 29, 2024 in |
Background: Bauhinia purpurea L. is a flowering plant belongs to family Leguminosae, also known as purple orchid plant. All parts of this plant including leaves, stem bark, flower and pods are edible and used for various medicinal purposes. Detailed pharmacognostic profiling of various parts has been performed except plant Pod, thus pod was selected for this study. Objective: The purpose of this work was to enrich the research on B. purpurea L. Pod in respect of pharmacognostical, physicochemical, qualitative identification of secondary metabolites by HPTLC and ethno-botanical profiling. Material and Methods: Entire pod and powder were subject to macro and microscopic study, different physico-chemical parameters including ash, extractive, moisture and pH determined through standard methods with analytical grade chemical and standard equipments. Quantitative estimation of phenolic content was performed by well-known Folin-Ciocalteu method and HPTLC developed through Vision cat software. Result: Fresh pod is green, elongated with sub-orbicular seeds. TS show different parenchymatous arrangement with yellow brown tannin content and Ca-oxalate crystals. Alkaloids, tannin, phenolic and flavonoids were reported...
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Posted by admin on Feb 29, 2024 in |
The quantitative measurement of Axitinib and Avelumab has been created using a simple, quick, precise, sensitive, and reproducible reverse-phasehigh-performance liquid chromatography (RP-HPLC) method. It is more difficult to analyse varying amounts of pharmaceutical active medicinal ingredients in dose forms without any interferences. Therefore, the objective of the current work is to estimate Axitinib and Avelumab simultaneously by adopting an Analytical Quality by Design (AQbD) arotatable central composite-based technique using RP-HPLC-based method development and validation. Axitinib and Avelumab were separated by chromatography using a Hyperclone 5µ BDS C18 130A (150 x 4.6 mm, 5μ) column and a mobile phase made up of Acetonitrile: 0.1% TEA pH-2.5/OPA in a ratio of 45:55 v/v. The flow rate was 1.2 ml/min, and a Photodiode Array Detector operating at room temperature was used to detect absorption at 219 nm. ICH criteria have been used to validate the offered techniques’ linearity, accuracy, precision, and other attributes. The degradation study’s findings showed that the medications deteriorated in high-stress situations. The chemical and pharmaceutical sectors might easily...
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Posted by admin on Feb 29, 2024 in |
Medication Adherence is defined as “the extent to which a person’s behavior in taking medication, lifestyle management, diet, corresponding with an agreed recommendation from a healthcare provider”. Hypertension also called high blood pressure is defined as persistency with an elevation in systolic blood pressure ≥140 mmHg and /or diastolic pressure ≥ 90 mmHg. A cross-sectional study was carried out in order to measure medication adherence, Morisky Green Levine-Medication Adherence Questionnaire developed by Donald Morisky was used to assess medication adherence assessment, which consists of 4 questions (items) whose wording questions are formulated to avoid answering ‘yes’ or ‘no’ and three levels of medication adherence: high, medium, and low were measured based on the scores 0, 1-2,3-4 respectively. The study carried out an evaluation of medication adherence among hypertensive patients. Among 245 respondents, 5.7% were found to be highly adherent, 37.6% were found to be medium adherent and 56.7% were found to be low adherent. A significant association between a family history of hypertension, diabetes, and smoking behavior was observed....
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Posted by admin on Feb 29, 2024 in |
C. splendens is a medicinal plant used for various ailments within the West-African Community. This study sought to investigate the pharmacognostic characteristics, mycobactericidal, and mutagenic activities of the hydro-ethanolic leaves extract C. splendens. The organoleptic, microscopic, macroscopic and physicochemical characteristics were investigated according to WHO, 2011 quality control methods for herbal materials. The mycobactericidal and mutagenic activities were investigated by the agar well diffusion assay and the Ames test (Muta-ChromoPlateTM) respectively. Present in C. splendens are tannins, flavonoids, glycosides, saponins, steroids and alkaloids which are comparable to published literature. The leaves of had anomocytic stomata, and starch granules, while calcium oxalate crystals were visibly absent. The 50% ethanol extract of C. splendens was not active against M. smegmatis at the highest concentration of 100 mg/mL. C. splendens was also non-mutagenic. Though the extract exhibited no mycobactericidal activity at the highest tested concentration, the documented pharmacognostic characteristics can be used for the purposes of authentication. Also, the non-mutagenic potential indicates a lack of toxicity in that...
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