Posted by admin on Jul 31, 2016 in |
A new physiologically active compound E-2-((2-amino pyridine-3-yl) methylene amino)ethane thiol derived from the condensation of Cysteamine and 2-amino Pyridine 3-Carbaldehyde was synthesized and characterized by spectral techniques like IR, UV-Vis,1H- NMR, TG-DTA, ESR, CHN analyses. The complexes were further screened for their biological activity at Nishka labs and Nickel and Cobalt complexes were found to be potent antibacterial agents. From the above analysis it was found that the ligand behaves as a neutral ligand with N: N: S:N:N donor sequence for octahedral...
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Posted by admin on Jul 31, 2016 in |
The chemotherapy prescribing errors (PEs) can lead to tragic consequences for the oncology patients. This cross-sectional observational study aims to predict the incidence of prescribing errors involving chemotherapeutic agents, and review their severity, through examining a random sample of 500 cancer patients at the out-patient chemotherapy unit of Ain Shams University Hospital, Cairo, Egypt; from March 2014 till August 2014. British Columbia Cancer Agency (BCCA) data base was used as a reference to identify the PEs. Prescription errors were classified according to their incidence and severity; in addition the relation between the risk factors and the observed PEs was studied. The study revealed that all the cases contained at least one error, the most common error incidence was the unspecified tumor staging in the protocol template (n=341, 68%), followed by dose error incidence (n=317, 66%). The risk factors predicting the prescribing medication errors were identified as: the protocol type, the tumor type, the toxicity type of the antineoplastic regimen, and others. Therefore identification of risk factors leading to prescribing...
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Posted by admin on Jul 31, 2016 in |
The present research aimed to evaluate the binding effect of hydroalcoholic extracts of leaf and Stem bark of Prosopis cineraria (PCL and PCB) with Calf Thymus (CT) DNA. The interaction of the PCL and PCB with Calf Thymus (CT) DNA has been studied using absorption spectra, viscosity measurements and cyclic voltammetry methods. It was observed that the PCL and PCB exhibited hypochromic and bathochromic shifts in the absorption spectra on binding to DNA which is a typical characteristic of DNA intercalation. In viscosity measurements, varying concentration of PCL and PCB causes a significant increase in viscosity of DNA. The variations of the cyclic voltammetric behavior of both extracts PCL and PCB was noted which demonstrate intercalative interaction between the PCL, PCB and the CT-DNA. In conclusion, both PCL and PCB possessed good DNA-binding...
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Posted by admin on Jul 31, 2016 in |
Oxidative stress is a condition due to excessive production of free radicals than the ability of the antioxidant system to counteract them. Antioxidants scavenge and suppress the deleterious effects of free radicals. Both exogenous and endogenous sources of antioxidants are important in pathological conditions. Exogenous antioxidants include dietary sources and even include medicinal plants. These medicinal plants contain phytochemicals which contribute to the beneficial antioxidant activity. Wheat germinated over a period of 9-10 days is generally called wheat grass. The purpose of this work is to determine the phenolic, flavonoids, flavonols and total alkaloids from wheat grass juice. Free radical scavenging activity of wheat grass juice was evaluated by using DPPH , nitric oxide, hydroxyl radical and total antioxidant power by FRAP assay and antilipidperoxidation activity by using mice liver and brain. Wheat grass juice is found to have good antioxidant action in various models due to its polyphenols and...
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Posted by admin on Jul 31, 2016 in |
Ischemic heart disease (IHD) is the major cause of morbid-mortality in most countries. The involvement of inflammation and oxidative stress (OS) in the development of atherosclerosis, ischemic cardiopathy triggering phenomen, has been investigated. The high sensitive C-reactive protein (hs_CRP) was measured in serum by immunoenzymatic method. Serum total homocysteine (Hcy) concentration was measured by fluorescence polarization immunoessay. Plasma levels of substances reacting with thiobarbituric acid (TBARS) were carried out by fluorimetric method (Yagi). Erythrocyte activity of superoxide dismutase (SOD) and plasma total antioxidant status (TAS) were determined by a colorimetric method at 505nm and 600nm, respectively. Erythrocyte activity of catalase (CAT) was measured by colorimetric assay (Goth). Our study showed significant elevation of hs_CRP, TBARS and Hcy levels in patients compared to controls. While we noted significant decrease in TAS levels, SOD and CAT activities in patients compared to the control group. We also noted positive correlations between: hs_CRP-Hcy, hs_CRP-TBARS, Hcy-TBARS, SOD-TAS, CAT-TAS and negative correlations between: hs_CRP-SOD, hs_CRP-CAT, hs_CRP-TAS, TBARS-SOD, TBARS-CAT, TBARS-TAS, Hcy-SOD, Hcy-CAT and Hcy-TAS. This unsuitability,...
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