Posted by admin on Jul 21, 2016 in |
Advances in nanoparticulate frameworks for enhanced medication conveyance show an extraordinary potential for the organization of urgent dynamic particles. The fundamental motivation behind creating elective medication conveyance advances is to build proficiency of medication conveyance. Pterospermum acerifolium is normal plant in India is viewed as carminative, stimulant and emmenagogue. The point of this study was to figure another conveyance framework for impacts of neurobehavioural by the joining of concentrate of Pterospermum acerifolium into strong lipid nanoparticles SLN. SLN plans were set up by ethanolic extricate implanted lipid layer was softened by warming at 5°C above liquefying purpose of the lipid. After that, SLNs were sifted and dried .Shape and surface morphology of the strong lipid nanoparticles were envisioned by filtering electron microscopy (SEM).Particle Size and Size Distribution were dictated by Photon relationship spectroscopy (PCS). The change of molecule charge was considered by Zeta Potential (ZP) estimations. The CNS action was examined in a few test models for Epilepsy i.e. Limit Pentylenetetrazole prompted seizure, Models for anxiolytic study i.e. Hoisted...
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Posted by admin on Jul 9, 2016 in |
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study was to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric bioanalytical method for the estimation of candesartan in pure form. For the estimation of candesartan, solvent system employed was absolute methanol and wavelength of detection (λdet) was 268.8 nm for first order derivative spectroscopy. The linearity was obtained in the range 2 – 10 µg/ml with a regression coefficient of R2 = 1. The limit of detection is 0.99 µg/ml and limit of quantification was found to be 3.1 µg/ml. Obtained results showed that there is minimum intraday and inter day variation. The developed method was validated and recovery studies were also carried out. Sample recovery using the above method was in good agreement with their respective labeled claims, thus suggesting the validity of the method and...
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Posted by admin on Jun 30, 2016 in |
Due to the increasingly tight controls around compliance, pharmaceutical firms continue to seek more efficient ways to track, document and report on code changes in regulated applications such as those developed for managing samples and inventory. Such applications and electronic signatures associated with application development and workflows are subject to stringent regulations such as Sarbanes-Oxley Act (SOX), in addition to related audits. The pharmaceutical industry is in a state of flux, and the increasing regulations are making their job even more challenging! One of the outcomes of the introduction of the Sarbanes-Oxley Act focused organizations toward compliance and controlling changes in their environment. This adherence to compliance helped to stabilize environments to some extent and organizations spent a lot of money and energy into becoming compliant and putting controls into place. Every change introduced to the system has the ability to “break” the system. The amount of changes and the speed at which change is introduced is directly proportional to disruptions in service and downtime. As the pharmaceutical environment...
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Posted by admin on Jun 30, 2016 in |
The paper focuses on different marketing techniques in Pharmaceutical Industry with reference to anti-ulcer drugs. This is an industry where a number of characteristics like, efficacy, quality and safety matters while delivering a product (i.e. the drug). This study comes up with drug development and the various aspects of bringing the product to the market. Secondly, it deals with determining the relationship between type of anti-ulcer drug prescribed and various product related factors. Thirdly, it focuses on strategies required for establishing strong presence in the therapeutic category. Methods and Materials: Testing of hypothesis is conducted among the type of anti-ulcer drug prescribed and elements of the marketing mix. Result: The important elements in prescribing anti-ulcer drugs to patients are...
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Posted by admin on Jun 30, 2016 in |
Rilpivirine (RILP) is non-nucleoside reverse transcriptase inhibitor. It is indicated for the treatment of HIV-1 infection. The current investigation was aimed to formulation and evaluation of solid self nano emulsifying drug delivery system (S-SNEDDS) for Rilpivirine to enhance solubility and dissolution rate. Solubility of drug was determined in different vehicles. Pseudo ternary phase diagram generated using PEG 400, cremophore RH 40 and Transcutol 90. The S-SNEDDS was prepared by adsorbing the optimized liquid SNEDDS on to neusilin US2 as carrier. The S-SNEDDS characterized by micromeritic properties, differential scanning studies, percentage transmittance, emulsification time and zeta potential. The optimized formulation had shown globule size of 16.27 nm with PDI of 0.276, less emulsification time of 30.2sec, good % transmittance (97.152±0.414) and good in vitro release. The in vitro dissolution rate of the drug from the s-SNEDDS was three folds than that of the plain drug and its suspension respectively cumulative percentage of drug release was found to 96.9±2.66 in 90 minutes. Accelerated stability studies was performed at 400C and 75%RH for s-SNEDDS of Rilpivirine...
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