Posted by admin on Apr 30, 2016 in |
Medicinal plants therapeutic agents are a big source of information for a wide variety of chemical constituents which could be developed as new drugs. The present study focused on anticancer, antitumor anticarcinogenic and cancer preventive activities of bioactive compounds found in plants belonging to Fabaceae family. The bioactive compounds and their scientific details were mining from publically available phytochemical databases (Dr. Duke’s phytochemistry and ethnobotanical database and USDA phytochemical database). Fabaceae family is one of the largest family which includes 18,860 plant species, of them, 12 plant species were identified to posses 106 bioactive compounds related to cancer treatment. The plant species such as Acacia nilotica, Arachis hypogaea, Cajanus cajan, Crotalaria juncea, Glycine max, Mimosa pudica, Pisum sativum, Psoralea esculenta, Tamarindus indica, Trifolium pratense, Trigonella foenum-graecum and Vigna subterranean possess bioactive compounds leading to cancer treatment. The important and mostly studied phytochemical compounds are Beta carotene, Alpha tocopherol, Alanine, Genestein, Caffeic acid, Tannin, Alpha carotene, Ascorbic acid, Limonene, Daidzein, Rutin and...
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Posted by admin on Apr 30, 2016 in |
This study was carried out with an objective to investigate the antibacterial and antifungal potentials of leaves of Ficus arnottiana Miq. The aim of the study is to assess the antimicrobial activity and to determine the zone of inhibition of extracts on some bacterial and fungal strains. In the present study, the microbial activity of ethyl acetate, methanol and aqueous extracts of leaves of Ficus arnottiana Miq. was evaluated for potential antimicrobial activity against medically important bacterial and fungal strains. The antimicrobial activity was determined in the extracts using agar cup method. The antibacterial and antifungal activities of extracts (50, 100, 200 μl) of Ficus arnottiana were tested against two Gram-positive—Staphylococcus aureus, Bacillus subtilis; two Gram-negative Escherichia coli, Pseudomonas aeruginosa human pathogenic bacteria; and two fungal strains Fusarium solanii, Candida albicans. Zone of inhibition of extracts were compared with that of different standards like Doxycycline for antibacterial activity and fluconazole for antifungal activity. The results showed that the remarkable inhibition of the bacterial growth was shown against the tested...
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Posted by admin on Apr 30, 2016 in |
Aim: To analyze the percentage cost variations among different brands of the commonly prescribed anti–hypertensive drugs. Materials and Methods: The cost of different brands of commonly used antihypertensive drugs was sorted out by referring latest CIMS, MIMS, Drugs Monitor and IDR. The cost of 10 dosage forms (Tablets / capsules) in INR of each brand, Cost Ratio and Percentage Cost Variation were calculated. Results: The percentage variation in the cost was above 100% with most of the commonly used antihypertensive drugs like Amlodipine (2.5 mg) 1040.58%, Atenolol (50 mg) 564.10%, Telmisartan (40 mg) 542.22% and Ramipril (10 mg) 478.39%. Among the combination therapy Atenolol + Hydrochlorothiazide (50 + 12.5 mg) 504.82%, Amlodipine + Atenolol (5 + 50 mg) 437.86% and Lisinopril + Hydrochlorothiazide (5 + 12.5 mg) 403.33% variation Conclusion: Hypertension is the most common cardiovascular disease and drugs are to be prescribed for prolonged period. If a costly brand is prescribed, the patients have to pay more money unnecessarily for their treatment. The costly brand of same generic...
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Posted by admin on Apr 30, 2016 in |
The study presents a protocol for mass propagation of Chlorophytum borivilianum through direct somatic embryogenesis. Direct somatic embryos occurred on the surface of juvenile shoot bud sprouts cultured on Murashige and Skoog medium supplemented with 5 mg L-1 BAP, yielding a high frequency of direct somatic embryos. On the other hand, a much lower concentration of BAP (0.5 mg L-1) led to the proliferation of somatic embryos. The conversion of somatic embryos with high MRN and MRL was favoured on BM. Encapsulation of somatic embryos (<5 mm) in calcium alginate beads resulted in the formation of well-formed synthetic seeds. Out of the synthetic seeds prepared from the somatic embryos (direct) using three types of gel matrices viz. DW, BM and SM, the ones formed using SM resulted in the highest frequency of germination (86.1%). Seed coat breakage and germination of synthetic seeds with the emergence of the tap roots were visible within 1-2 weeks of culture on basal medium. The plantlets obtained were successfully hardened on sand-soil-farmyard manure mixture...
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Posted by admin on Apr 30, 2016 in |
Cellulite is a normal condition judging from the medical aspect, but from aesthetics aspect, cellulite deserves more attention, especially for women. Centella asiatica is reported to promote both fibronectin and collagen synthesis. Meanwhile, Zingiber officinale is reported to have lipolysis activity. Combination of the two herbals is assumed to have complementary effect as anti cellulite agents. The combination of the herbal extracts is prepared in nanoemulsion form to enhance the bioavailability. The study aimed to determine the effect of nano emulsion of C. asiatica and Z. officinale combination (proportion of 5:1) to stimulate skin collagen synthesis and decrease the diameter of adipocyte cells using histological parameters as an indicator of lipolysis activity. Twenty female Wistar rats weighing 120-140 g were fed a high-fat diet for 30 days. The animals were divided into 4 groups, with the 3 groups received the nanoemulsion of herbal combination with the dose of 50, 100, and 200 mg/kg BW for 30 days, and 1 group received CMC Na 0, 5% as negative control. On...
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