Posted by admin on Jun 30, 2016 in |
Interferon-γ (IFN-γ), a defense molecule, mediates its response against viral infections like Hepatitis B virus by binding to interferon gamma receptor 1 (IFNGR1) on cytotoxic T lymphocytes (CTLs). Hence, interferon gamma receptor 1 (IFNGR1) gene expression is vital in the eradication of the HBV virus. It has been demonstrated by some studies that -56C/T SNPs in IFNGR1 gene promoter region can be correlated with HBV-infection resistance or susceptibility. It has also been shown that -56C SNP has protective effect against HBV infection in comparison to -56T SNP. This motivate us to find out the percentage prevalence of -56C/T SNPs in our healthy population. Genomic DNA was extracted using standard phenol-chloroform method from healthy blood donors. PCR was performed to amplify the 491 bp region of IFNGR1 gene promoter region and digested with AfeI restriction enzyme to observe the -56C/T SNPs. Allele ‘T’ has been observed as the overall dominant allele (65.71%) in our both male (71.79%) and female (58.06%) healthy...
Read More
Posted by admin on Jun 30, 2016 in |
Chronic Kidney Disease is a considerable problem requiring coincident use of several medications in order to manage the condition and co morbidities. Medication adherence rate are diminished by complex drug regimens. Generally poly pharmacy fabricates chances of poor adherence and adverse drug reactions (ADRs). In Chronic Kidney Disease (CKD) functioning of kidney is poor and decreased elimination of drugs leads to serious consequences. In this study 144 CKD patients were enrolled. The mean age was found to be 54.97 (±13.425). CKD was more common in male (66%) than female (34%). Majority of the patients were diagnosed with Hypertensive Kidney Disease and Diabetic Kidney disease and using 4 to 6 drugs concurrently. This shows that hypertension and Diabetes are the main risk factor for CKD in these patients. Most of the patients enrolled in the study were diagnosed with CKD for more than 3 years. Patients with CKD were commonly using the drugs like Antihypertensives, Antidiabetics and other cardiovascular drugs. Most of the patients were highly adherent to the medications...
Read More
Posted by admin on Jun 30, 2016 in |
Purpose: Diabetes mellitus is a significant burden to the present society, associated with various co-morbid conditions like hypertension, cardiovascular diseases, etc. A number of drugs are available to handle these health problems successfully. However, therapeutic success of such diseases is limited due to adverse effects of drugs or medicines. The aim of the present study was to evaluate the cases of adverse events due to these medications. Methods: An observational study on patients attending the Out Patient Department (OPD) of R.G. Kar Medical College, Kolkata, West Bengal, India, for a period of 8 months (September 2014- April 2015). Adverse drug events due to the use of anti-diabetic and cardiovascular drugs were collected and evaluated. Result: Present study revealed that, out of the total 48 adverse event reports collected in patients using anti-diabetic and cardiovascular drugs, 66.7% may be due to anti-diabetic drugs and 31.25% may be due to cardiovascular drugs. The prevalence of adverse effects due to antidiabetics was more in female (62.5%) as compared to male (37.5%). 40.63%...
Read More
Posted by admin on Jun 30, 2016 in |
The purpose of the study is to update and review the latest developments related to modelling and economic evaluation of osteoporosis and further to present a reference model for the assessment of the cost of the prevention and treatment of osteoporosis. To find out the most cost-effective drug combination between the two combinations (Alendronate + Vitamin D supplements & Strontium ranelate +Calcium supplements) in osteoporotic & severe osteoporotic patients and health related quality of life of osteoporotic patients. A prospective observational comparative study (Cost-effectiveness Analysis) was carried out in 60 patients in which 30 each in severe and very severe Osteoporotic groups, who are prescribed with any one of the following combinations (Alendronate+Vitamin D supplements and Strontium ranelate+Calcium supplements) were selected. We have used 3 different parameters such as bone mineral density test (initial and final values), health related quality of life and X-Ray. Comparison of costs and effects were done. The mean of the calcium values of group 1 (Alendronate + Vitamin D supplements) during their initial visit...
Read More
Posted by admin on Jun 30, 2016 in |
Urolithiasis is a relevant clinical problem in every day practice with a subsequent burden for the health system. Animal models of disease most closely replicate the sum of physiological conditions present in humans. Rats and mice are however, the two most commonly used experimental animals in medical research including stone disease. The oxalate metabolism in the rat is nearly identical to that in humans in many aspects. The experimental calcium oxalate Urolithiasis in the rat is similar to calcium oxalate stone disease in man. There are many methods of inducing calculi in rats. Among them Chemical method of inducing hyperoxaluria with Ethylene glycol and foreign body implantation especially zinc discs in urinary bladder of rats are the commonly used experiments. This paper will describe in detail about the Zinc disc implantation method to induce calculi in Wistar rats based on a pilot study. Focus is given to the specifications of zinc disc size, duration of calculi formation and X- ray radiography so that it will be very useful for...
Read More
