Posted by admin on Apr 30, 2016 in |
Jivanti is considered a stimulant and tonic in Ayurvedic literature. Its medicinal use dates back to about 4500 to 1600 BC, as mentioned in classical texts. Holostemma ada- kodien and Leptadenia reticulata are the two plants used in Ayurveda as source plants of the drug Jivanti. Roots of these plants are used in several Ayurvedic preparations. Though Ayurvedic Formulary of India mentions Leptadenia reticulata as the source plant of Jivanti, throughout Kerala and mostly in South India, Holostemma ada- kodien is used as source plants of Jivanti and there are reports regarding adulteration in market samples, which will adversely affect the quality of medicines prepared. Till now there is no significant study to compare the source plants available in markets as Jivanti. Present work is a comparative histological, histochemical and phytochemical study of the raw drug Jivanti from different raw drug markets of Kerala. This is a first time approach to develop quality control measures with the help of histological, histochemical and phytochemical...
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Posted by admin on Apr 30, 2016 in |
The present study was taken to prove the cytotoxic effect of ethanolic extract of Gmelina asiatica leaf on human breast cancer cell line MCF-7. The in vitro cytotoxicity was evaluated by performing MTT assay. Cell morphological characteristics were observed by using phase contrast microscope. The results demonstrated in MCF-7 cancer cell lines treated with ethanolic extract of G. asiatica leaf showed the cell death which is dose dependent. Only 8.2 % of cell viability was observed at 1000µg/ml concentration of G. asiatica leaf extract. It is concluded that the ethanolic extract of Gmelina asiatica leaf can be used for the treatment of breast...
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Posted by admin on Apr 30, 2016 in |
Objective: To observe the variations in levels of serum amylase and serum lipase, in patients with type 2 DM after treatment with DPP-4 inhibitors. METHODS: Under this study, 174 Type 2 diabetes mellitus patients were analysed for variations in levels of exocrine pancreatic enzymes after use of dipeptidyl peptidase (DPP) 4 inhibitors. The effect was compared with those under treatment with other oral hypoglycaemic agents. Cases included in the study (n=90) were patients of type 2 diabetes mellitus on gliptins ± other oral hypoglycemic drugs. The control (n=84) included age and sex matched subjects, treated with other antihyperglycemic agents other than gliptins. Serum amylase and serum lipase levels were monitored at baseline, 3monthly and 6 monthly intervals. Results: Mean serum amylase levels in cases as compared to controls at 3 and 6 monthly intervals were 61.38±14.35U/L;94.57 ± 22.99U/L and 43.34± 9.80U/Land 45.72 ±8.40 U/L respectively. Difference between two groups was statistically significant at both time intervals. Similarly mean serum lipase levels in cases as compared to controls at 3...
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Posted by admin on Apr 30, 2016 in |
This study posed a challenge for the risk management to research and development projects in a highly regulated and volatile pharmaceutical industry, in which projects are extremely long, complex, costly and prone to failure. Project management in new product development, must be efficient and effective. This emphasizes the importance of risk management. Quality by design (QbD) refers to an advanced approach toward drug development. QbD is a vital part of the modern approach to pharmaceutical quality. There is much confusion among pharmaceutical scientists in generic drug industry about the appropriate element and terminology of QbD. The purpose of this research was to discuss the pharmaceutical QbD for formulation development with a case study of Orally Disintegrating Tablet (ODT) of Donepezil Hydrochloride (DPH). The study describes elements of the QbD for DPH ODT, include: Defining quality target product profile, identifying critical quality attributes, establishing design space, control strategy. ODT of DPH was prepared by direct compression method using Crospovidone, MCC and level of polymer was optimized, factorial design was used...
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Posted by admin on Apr 30, 2016 in |
Azima tetracantha Lam. (Salvadoraceae) is a traditional medicinal plant primarily used for mother care treatments after delivery. Based on literature survey, it was noticed that the evaluation of the biopotential of A. tetracantha, and its phytoconstituents are scarcely reported from plant materials growing in the state of Kerala, India. An attempt was made to reveal the phytochemical profile of the plant using various chromatographic as well as spectroscopic techniques. A triterpenoid of friedelane derivative, was isolated from the leaves of A. tetracantha by employing chromatographic techniques like Column chromatography and thin layer chromatography (TLC), along with preparative TLC. The isolated compound was observed to be white coloured powder consisting of needle shaped crystals. The melting point of the isolated compound was found to be 261- 263 ºC (uncorrected). The crystals were soluble in hexane, acetone, ethyl acetate and methanol. It was insoluble in water. Further spectroscopic characterization using ultra- violet spectroscopy (UV-Vis), infra red spectroscopy (FTIR), liquid chromatography mass spectrometry (LCMS) and 1H- NMR. of the compound revealed it...
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