Posted by admin on Mar 31, 2016 in |
The objective of present study was to preclude of poor dissolution of relatively water insoluble and poorly permeable drug by formulating gastroretentive floating tablet using solid dispersion (SD) of the drug. It aimed to increase the drug solubility and gastric retention of the drug for better absorption profile. Cefpodoxime proxetil is an orally absorbed third generation cephalosporin antibiotic. The oral bioavailability and biological half life is 50% and 2.09 to 2.84 hrs respectively. Two grades of Polyethylene glycol (PEG); PEG 4000 and PEG 6000 in combination were used for the formulation of solid dispersion. Formulation batch SD8 was found to be optimized according to the face centred cube design (FCCD). Solubility and the drug release from batch SD8 was maximum in 0.1N HCL, 18.93mg/ml and 94.66% respectively as compared to physical mixtures (PM) and pure drug. The physical mixture having same carrier ratio (PEG 4000+PEG 6000) that is PM8 has solubility and drug release 13.93mg/ml and 76.34% respectively. The study showed that solubility and drug release has linear relationship...
Read More
Posted by admin on Mar 31, 2016 in |
Gentamicin causes kidney cellular damage by alterations in biological functions. This study evaluated the nephroprotective potential of the ethanolic extract and its fraction originating from Sapindus emarginatus Vahl. (Sapindaceae) bark against the Gentamicin – induced nephrotoxicity in rat. Objective: To evaluate the nephroprotective effect of ethanol extract and its organic solvent fraction of S. emarginatus Vahl. in gentamicin-induced acute renal failure in rats. Materials and Methods: Nephrotoxicity was induced in wistar rats by intraperitoneal administration of gentamicin 100 mg/kg/day for ten days. The treatment was done with silymarin 50 mg/kg, ethanol extract 200 mg/kg/p.o. and its ethyl acetate fractions 100 mg/kg/p.o. bark of S. emarginatus was determined using parameters serum creatinine, urea, uric acid, blood urea nitrogen, albumin, protein, other parameters are kidney weight, body weight, urine volume and histopathology of kidney. Results: It was observed that the ethanol extract and its ethyl acetate fractions bark of S. emarginatus has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner. In...
Read More
Posted by admin on Mar 31, 2016 in |
The present work aims to examine the antimicrobial activity of three medicinal plant extracts grown in Saudi Arabia namely Pulicaria crispa, Achillea fragrantissima and Cleome Africana against 10 clinical isolates of multi-drug resistant bacteria (MDR) that belong to four species, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumonia. The antibacterial potential of the methanolic plant extracts was assessed by the agar well diffusion method and expressed in terms of diameters of inhibition zone. The outcomes of these experiments indicated that each extract has shown an activity against four resistant isolates at least, with maximum zone of inhibition 19 mm recorded by P. crispa extract against S.aureusstrain (1). As a new finding, it was observed that C. Africana extract has bioactivity as antibacterial agent against maximum number of resistant isolates (seven out of ten tested strains) including all tested isolates of S.aureus (ranged between 7 and 14 mm). Methanolic extract of A. fragrantissima demonstrated two considerable growth inhibition against one isolate of both S.aureus and Ps. aeruginosa. The chemical...
Read More
Posted by admin on Mar 31, 2016 in |
The current study aimed to test the effect of the aqueous extract of Boswellia dalzeilii and Pseudecedrela kotschyi using three different mixing ratios (B. dalzeilii:P. kotschyi) 3:1, 2:2, and 1:3. The assays concerned the study of the interactions in the modulation of phagocytic index, nitric oxide production, lysosomal enzymes and myeloperoxydase activity in macrophages and regulation of lymphocytes proliferation. The study results showed that the extracts of these plants exhibited antagonistic effects in the phagocytic index and production of NO while they produced synergetic effects in the stimulation of MPO-dependent activity and lymphocytes proliferation. Antagonistic effects were produced in the ratios 3:1 and 2:2 and synergetic properties in the ratios 1:3 for the stimulation of the activities of the lysosomal enzymes. These results look quite interesting and important and merit further investigations to support the present...
Read More
Posted by admin on Mar 31, 2016 in |
Atorvastatin calcium (ATC) is very slightly soluble in water and it is classified under BCS class II drugs. A widely used method to enhance the solubility of drugs is co-crystallization. In this work, we screened six co-formers for ATC by employing molecular docking method. The work was continued by co-crystallization process using slurry method, solubility assay of the mixtures using HPLC, and characterization of the co-crystal by PXRD, DSC and SEM. Based on molecular docking, the best co-former is aspartame (Ei = -4.70 kcal/mol). The docking result fits the solubility assay of the ATC-aspartame co-crystal (136.77% increasing of solubility compared to ATC). ATC-aspartame co-crystal shows better dissolution profile (91.62 % in 60 minutes) than ATC (73.54 % in 60 minutes). The characteristic peaks of ATC and aspartame were gone, whilst new peaks appeared after slurry process. The ATC-aspartame characterization by PXRD, DSC and SEM positively confirmed that the co-crystallization of ATC-aspartame using slurry method was...
Read More
