Posted by admin on Jan 31, 2016 in |
A simple and sensitive spectrophotometric method was developed and optimized for the determination of content of mono isopropylamine at very low levels in Carisoprodol and Isoproterenol hydrochloride. The method was based upon the observation, that characterstic colour results up on addition of colour reagent (consists of Acetyl acetone, formaldehyde and pyridine) and heat for 10 minutes on water bath to form coloured complex. This coloured complex is slightly yellow and its absorption maximum at 420 nm. The optimized method was validated to prove its performance characterstic by demonstrating selectivity, sensitivity(limit of detection and quantification), linearity, precision and accuracy. The established limit of detection and limit of quantification of mono isopropylamine was found to be 3.3µg/ml and 10µg/ml respectively. The present work was aimed to develop a visible spectrophotometric method, which is simple, sensitive, accurate and cost effective to evaluate the quality of the bulk...
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Posted by admin on Jan 31, 2016 in |
Zingiber cernuum belongs to family Zingiberaceae is a perennial herb, also called as Curved stem ginger. The rhizomes of Zingiber cernuum is steam distilled and the composition of essential oil was studied. The essential oil obtained was yellow in colour and the yield was about 0.007%. The chemical profile of the oil was obtained from their GC-MS analysis. The major components present in the oil are trans-Caryophyllene, α-Humulene and δ-3-Carene. The antimicrobial activity of the essential oil was studied using disc diffusion method. The essential oil was tested against four pathogenic stains of gram positive and gram negative bacteria. The essential oil of Zingiber cernuum show considerable antibacterial activity. The oil was found to be active against both gram positive and gram negative bacteria. The anti bacterial activity is mainly due to the major components present in the oil or due to the synergistic effect of the major and minor...
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Posted by admin on Jan 31, 2016 in |
Objective: to investigate the anti diabetic effect of ethanolic extract of Cinnamomum zeylanicum on Alloxan induced diabetes in experimental animals (Rats). Materials and Methods: the alcohol extract of Cinnamomum zeylanicum was tested for its efficacy in Alloxan (150mg/kg) induced diabetic rats. The diabetic rats were divided into 5groups. Group I (control) received 2% gumacasia, groupie (positive control) received standard drug Glibenclamide (10mg/kg+2%GA), group III, IV, V (T1 T2 T3) were treated orally with a daily dose of 50mg/kg, 100mg, 200mg, respectively for 30 days, for all diabetic rats after giving Test, NC, PC preparations, the blood samples were collected and determined the blood glucose level 0,1,3,24hrs intervals. 0hr reading is before drug giving and remaining 3 readings after drugs giving. 24th her reading is considered as 0hr reading for the next day. Results: administration of alcohol of an extract of Cinnamomum zeylanicum produced a dose dependent decrease in blood glucose levels in Alloxan induced rats. There was significant fall in blood sugar level in High dose (200mg/kg) in comparison...
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Posted by admin on Jan 31, 2016 in |
Background: The WHO assembly in number of resolutions has emphasized the need to ensure quality control of medicinal plant products by using modern techniques and applying suitable standards. Since Ayurvedic medicines come under the purview of Drugs and Cosmetics Act, there is increased general awareness about the necessity for developing standards for the purpose of quality control by the manufacturers as well as by the Drug control Authorities and for quality assurance to the public. Standardization of Ayurvedic formulations is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs. Aim: To standardize Ashwagandha ghrita. Materials and methods: Physico‐chemical studies like Refractive index, Specific gravity, Rancidity, Boiling point / Melting point, Acid value, Saponification value, Iodine value and HPTLC were carried out as per the WHO guidelines, Ayurvedic Pharmacopoeia and Indian Pharmacopoeia. Conclusion: Standardization tests done on Ashwagandha ghrita helped in authenticating and ensuring the quality of the...
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Posted by admin on Jan 31, 2016 in |
The objective of present study was to develop Lornoxicam transdermal gel and its iontophoretic delivery to enhance its permeation for systemic effect and to avoid its side effects. Lornoxicam is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain, edema and rheumatoid arthritis. Transdermal gel of Lornoxicam was formulated using triethanolamine as solvent, carbopol 934P as gel base and enhancement in its permeation by iontophoresis was investigated. Formulated gel was evaluated for pH, viscosity, spreadability, drug content and gel strength. Permeation study was carried out using cellophane membrane for 6 hours. Anti- inflammatory activity of Lornoxicam gel was studied in albino rats by carrageenan induced paw edema method in which Lornoxicam was delivered through rat’s skin by passive delivery and iontophoretic delivery. Iontophoretic delivery of formulation F1 showed edema inhibition up to 62% whereas passive delivery of F1 showed 22% of edema inhibition in 1 to 6 hours. Edema inhibited by iontophoretic delivery was around 2.5 fold than compared to that of passive delivery; hence iontophoretic...
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