Posted by admin on Mar 31, 2016 in |
Background: Dengue is a major public health problem in resource-limited countries like India. There has always been a quest for best serological test for prompt and accurate diagnosis and whether single test or a combination be used. Enzyme immunoassays based on the detection of dengue virus non-structural protein 1 (NS1), and IgM antibody capture are available with different sensitivities and specificities observed in various settings. Aim: Diagnostic efficacies of two enzyme immunoassays, i.e. non-structural 1 (NS1) antigen-capture ELISA against IgM antibody capture ELISA to confirm cases of dengue infection in single acute serum samples have been evaluated and each test compared against the combination of the two. Material and methods: NS1 antigen (QUALISA Dengue NS1) and IgM capture ELISA (Calbiotech Dengue Virus IgM ELISA) were performed on 254 single acute serum and interpreted as per the manufacturer’s instructions. Results: The NS1 antigen detection and IgM antibody ELISA gave 25.59% and 17.3% positivity rates, respectively. The combination of two assays increased the overall detection rates to 30.7%. Noteworthy here is,...
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Posted by admin on Mar 31, 2016 in |
In the present paper QSAR studies related to some novel substituted pyrazole derivatives are reported. All the compounds were evaluated for antmicrobial activity viz- antifungal activity against A. niger. Their reported antimicrobial activities were used for Quantitative Structure Activity Relationship (QSAR) studies to find correlation between different calculated molecular descriptor of the compounds and biological activity. It is reported that five compounds viz. A-2, A-6, A-7, A-10 and A-11 showed maximum activity against A....
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Posted by admin on Mar 31, 2016 in |
The most common cause of death is bone marrow failure. Chromosomal analysis is essential for the diagnosis, response to treatment and prognosis of leukemia. The present study was done to know the chromosomal abbreviation in chronic leukemia of patients with in age group of 2 to 60 years. 32 male and 21 female patients have been analyzed for this study. The chosen leukemic patients were those who were reporting for bone marrow examination in the Hematology section of Pathology Department from the coastal District of Orissa.The chromosomal aberrations were taken into account in this present study and arranged in tables, Bar charts and Pie charts for comparison. Identifying the chromosomal changes in leukemic cells will help physicians to use targeted therapy, aimed at the specific genetic defect in the cancer cells responsible for leukaemia. Conventional karyotyping which shows the structural, numerical and compound aberrations have improved the genetic diagnosis of leukaemia. It forms an important platform on which pyramid of modern cyto and molecular genetics have been growing for...
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Posted by admin on Mar 31, 2016 in |
Kencur (Kaempferia galanga L.) is a plant of Zingiberaceae family. Some studies have shown that kencur can reduce inflammation because flavonoid kaempferol which is contained in kencur has anti-inflammatory activity. Optimized the use of the rhizome kencur, research was conducted on anti-inflammatory plaster containing kencur rhizome extract and its effectiveness for treating inflammation. The study was conducted through the stages of manufacture of plasters kencur rhizome extract and effectiveness of anti-inflammatory plaster test on acute inflammation. Based on this research, kencur rhizome extract can be manufactured as plaster. There were 5 groups of animals test using male white rats Wistar strain which is induced by carrageenan for acute inflamation test. The result showed by one-way ANOVA (analysis of variant) with a 95% confidence level, there was a significant difference between test groups and negative control group based on variation doses for inflamation test. Kencur rhizome ethanol extract can be used as anti-inflammatory plaster to reduce inflammation in...
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Posted by admin on Mar 31, 2016 in |
Cucumis sativus (Cucumbers) have not received as much press as other vegetables in terms of health benefits, but this widely cultivated food provides us with a unique combination of nutrients. At the top of the phytonutrient list for cucumbers are its cucurbitacins, lignans, and flavonoids. These three types of phytonutrients found in cucumbers provide us with valuable antioxidant, anti-inflammatory, and anti-cancer benefits. Cucumbers are a valuable source of conventional antioxidant nutrients including vitamin C, beta-carotene, and manganese. Fresh flowers of Cucumis sativus were extracted and evaluated for antioxidant activities by 2,2-Diphenyl 1-picryl hydrazyl solution (DPPH), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sul- phonic acid (ABTS) assay and anti-inflammatory activites by human blood cell (HRBC) membrane stabilization method and Inhibition of albumin denaturation method. The results obtained showed that the compound isolated from ethyl acetate fractions of Cucumis sativus flowers can be considered as good sources of anti-oxidants, anti-inflammatory and can be incorporated into the drug formulations. This study justifies the anti-oxidants, anti-inflammatory activity of the compound isolated from ethyl acetate fractions of Cucumis sativus flowers....
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