Posted by admin on Jan 31, 2016 in |
Subgingival obligate anaerobes present within the biofilm such as Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia and Aggregati bacter actinomycetemcomitans have been implicated in the initiation and progression of periodontal disease. Recent documentation has demonstrated that P.gingivalis is capable of maintaining its viability when exposed to oxidative stress by expressing Bat A and Bat B genes of the aerotolerance operon acting as virulence factors offering protection and further disease progression in the host. The present study aims to determine the presence of bat A and bat B genes in other periodontopathogenic species viz. Aggregatibacter actinomycetemcomitans, Tannerella forsythia and Prevotella intermedia, and the degree of homology using BLAST...
Read More
Posted by admin on Jan 31, 2016 in |
The objective of the present investigation is to study the possibilities to improve the aqueous solubility and dissolution rate of Tamoxifen citrate (TC) – an oral anticancer drug, based on inclusion complexes with a– cyclodextrin (α –CD). The inclusion processes are discussed based on absorption, emission, FT-IR, 1H-NMR, SEM and phase solubility study. The α –CD study shows that the drug form 1:1 inclusion complexes. The solubility and dissolution results revealed that there was a considerable increase in solubility and dissolution of all inclusion complexes. Scanning Electron Microscopy (SEM) to analyze physicochemical interaction between drug and carrier and evaluation of the crystal morphology and their approximate size. The inclusion complex appears as tiny aggrigates of amorphous pieces of irregular sizes. In both absorption and emission the intensity increase with increase in concentration of α –CD. The aromatic ring is encapsulated in the non-popular α –CD cavity. The formation constant value reveals a hydrogen bonding interaction is present between the drug and α –CD cavity. The presence of aliphatic chains...
Read More
Posted by admin on Jan 31, 2016 in |
The aim of this study was to investigate the potential antidiabetic activity of Piper betle in alloxen induced diabetics. Rats were divided into 6 groups and Piper betle was administered containing 50, 100 and 200 mg/kgbwt powder, respectively in 1ml water orally in group A, B and C rats. Metformin (150 mg/kgbwt) used as a reference standard drug. Blood glucose (BG), triglycerides (TG), total cholesterol (TC), high density lipoproteins (HDL), low density lipoproteins (LDL), serum glutamate oxaloacetate transaminase (SGOT) and serum glutamate pyruvate transaminase (SGPT) were estimated from the serum by using standard kits. Piper betle juice had shown significant lowered the blood glucose levels in all groups. In addition, body weight, organ (liver, kidney, heart and pancreas) weight, food intake, water intake were also examined in all treated groups and compared against diabetic control group. After 22 days daily administration of Piper betle, diabetic treated rats showed improvement in body weight, water intake as compared to diabetic control rats. In alloxan induced diabetic rats the maximum reduction in...
Read More
Posted by admin on Jan 31, 2016 in |
An hitherto new unreported [16]-membered dioxadiazanapthaldehyde based macrocyclic ligand (L) 2,11-dioxa-23,30-diaza heptacyclo [30.4.0.04,9.012,21.014,19.024,29.034,39] -tetraconta-12,14,16, 18,20,22, 24,26,28,30,32,34,36,38,40-pentadecaene, has been synthesized by two different synthetic routes each involving two stages. 2-Hydroxy-1-Napthaldehyde in the presence of potassium carbonate was treated with α,α’-dibromo-o-xylene to yield the dial derivative(I). The dial derivative(I) was further made to undergo Schiff base condensation with 1,2-diaminobenzene to yield the bright yellow macrocycle (L) in good yield. In the second method the Schiff base condensed product Napthaloph was synthesized and allowed to undergo Williamson’s condensation with α,α’-dibromo-o-xylene to yield the ligand (L). The neutral sixteen membered tetradentate dioxadiaza ligand(L) readily complexes with Co(III), Ni(II) and Cu(II) perchlorate salts in 1:1 mole ratio to yield complexes of formulae [Co(L)X2]ClO4, [Ni(L)X2], [Cu(L)X]ClO4, (X = Cl–, Br– and NO3–). The complexes were also synthesized by the metal template method. The yield of the template procedure was found to be greater than the non-template method. The ligand and the complexes were characterized by elemental analysis, electronic spectroscopy, IR, Conductivity measurements, EPR, magnetic susceptibility,...
Read More
Posted by admin on Jan 31, 2016 in |
The present investigation deals with the histological and histopathological altarations in Channa striatus infected with fungi Aspergillus fumigates and Aspergillus niger. Fresh water murrels were collected from Dharmasagar and Hasanparthy lakes and Local fish markets of Warangal district. This is due to the nature of their habitats as many native species of fish suffer from living beneath turbid water. Among the recent emerging infection diseases responsible for severe population declines in plant and animal taxa, fungal and fungi-like microbes have emerged as significant contributors. Isolated fungi from infected fish bodies were identified as Aspergillus fumigatus and Aspergillus niger. Histopathologically different kinds of destructions were observed in Skin, Muscles, Gills and Liver of the infected fish. Histopathological observations of stained sections of infected fishes revealed pathological lesions of varying severity in studied organs including skin (exhibits compeletely lost epidermis, destiended cells, many of cells lost their cytoplasm and nuclei. Necrotized muscular layer with the formation of granulomas and encysted conidiophores), gills ( hyperplasia and hyperplasia of lamellar epithelium, fusion of...
Read More
