Posted by admin on Jan 1, 2016 in |
The present study of wound healing activity of mimusops elengi linn was aimed to evaluate this activity of extract of leaves of mimusops elengi. On the basis of traditional use and literature reference, this plant was selected for wound healing activity. A meathanolic extract of leaves of mimusops elengi was examined for wound healing activity in the form of ointment in form of ointment in excision wound model. the ointment of extract of ointment showed considerable response in excision wound model in comparision of a standard drug Betadine ointment in terms of wound contract ability, wound closure time, tensile strength, dry granuloma weight, histological analysis also showed that mimusops elengi leaves extract exhibits significant wound...
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Posted by admin on Jan 1, 2016 in |
Kalanchoe genus is known for its therapeutic values. Kalanchoe pinnata (Linn.) Pers. originating from African continent is known to exhibit wound-healing, antioxidant, anticancer and hepatoprotective activities. Traditionally, it is used to treat stones of the gall bladder. Hence, determination of the phytoconstituents of the plant that are responsible for treatment of various ailments became the area under study. The plant samples were collected from Kanchipuram District, Tamil Nadu, India, to carry out various research analyses. In this study, the aqueous and solvent extracts of the plant were prepared and screened for the presence of phytocompounds by thin layer chromatography (TLC). A comparative study on both the extracts based on results obtained after TLC was made to choose the better amongst the extracts. A gas chromatographic mass spectroscopy (GC-MS) analysis of the chosen extract was performed to determine the compounds present in it. The GC-MS results obtained gave a new dimension to our research...
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Posted by admin on Jan 1, 2016 in |
To evaluate the antimicrobial activity of Octenidine (OCT) 0.1%, Chlorhexidine (CHX) 0.2% against bacterial strains of Enterococcus faecalis and Staphylococcus aureus. The strains were inoculated in 7ml of brain heart infusion broth and diluted to reach the concentration equivalent (0.5 McFarland standard). 1ml of organism suspension was contacted with 1ml of each mouthwash and was removed at time interval of 3,5 and 10 minute and plated on Brain Heart Infusion agar. After 72 hours of incubation, colony counts were measured using stereomicroscope. Kruskal Wallis test was conducted on mean number of CFU. Post-hoc tests were conducted by using the Mann Whitney U test and Duncan’s-test of multiple comparisons. The results showed that OCT 0.1% was found to be the most effective in substantially reducing total bacterial counts after 3, 5 and 10 min time interval. OCT 0.1% was found to be the most effective in substantially reducing total bacterial...
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Posted by admin on Jan 1, 2016 in |
Aim: To demonstrate the effect of Nimesulide in reversing Reserpine induced depression in mice. Materials and Methods: This test was done using 20-25gm of healthy albino mice of either sex in the Department of Pharmacology of Gauhati medical college. They were housed in standard laboratory condition at 25ºC and fed on standard diet and water ad libitum. Five groups were selected each containing six mice. The groups were Group I (Normal Control), Group II (Disease Control), Group III (Fluoxetine 10mg/kg i.p),Group IV ( Nimesulide 2.5mg/kg i,p) and Group V (Nimesulide 5mg/kg i.p)Reserpine (2mg/kg i.p) was used to induce depression in all the groups except the Normal Control. After 24 hours, the standard and test drugs were given and the mice were subjected to tail suspension test (TST) after 30 mins and forced swim test (FST) after 1 hour of injecting the drugs. Result: Mean±SEM values were calculated for each group. The data were analyzed using ANOVA and post analysis was done by Dunnett’s test. Results were found to be...
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Posted by admin on Jan 1, 2016 in |
The present investigation was attempted in order to evaluate the antifungal potential of successively extracted n-hexane and methanolic extracts of Melia azedarach L. bark. The fungi-toxic efficacy of the extracts were tested against both yeast like fungi [Candida albicans (MTCC-3017), Candida krusei, Candida tropicalis, Cryptococcus marinus (MTCC-1029)] as well as mycellial like fungi such as Aspergillus niger (MTCC-9933) and Rhizopus oryzae employing well diffusion and poison food method respectively. The study revealed that n-hexane extract exhibited high inhibition against Candida krusei, whereas Candida albicans and Candida tropicalis showed no response and Cryptococcus marinus responded moderately. The methanolic extract showed high inhibition against Candida krusei, whereas Candida albicans and Candida tropicalis showed no response and moderate effect against Cryptococcus marinus. The n-hexane and methanolic extracts of this plant showed better zone of restriction against Rhizopus oryzae than Aspergillus niger. Fluconazole and clotrimazole was taken as reference antifungal. The result clearly indicated that bark of Melia azedarach L. contains phytochemicals which are responsible for inhibition of fungal growth and...
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