Posted by admin on Oct 31, 2015 in |
Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes causes the combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The degree of hyperglycemia sufficient to cause pathologic and functional changes in various target tissues, but without clinical symptoms, may be present for a long period of time before diabetes is detected. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy with risk of foot ulcers, amputations, and Charcot joints; and autonomic neuropathy causing gastrointestinal, genitourinary, and cardiovascular symptoms and sexual dysfunction. Patients with type 2 diabetes have an increased incidence of atherosclerotic cardiovascular, peripheral arterial, and cerebrovascular complications. Aim: The aim of this study was to determine the association between plasma human cartilage glycoprotein 39 (YKL-40) and glycated hemoglobin (HbA1C) in type 2 diabetic patients. Materials and methods: Thirty type 2 diabetic patients with the age group of 35 to...
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Posted by admin on Oct 31, 2015 in |
Diarrhoea is a condition that involves frequent passing of loose or watery stools. According to the WHO, approximately 3.5million deaths each year are attributable to diarrhoea. Medicinal plants have been used as traditional remedy for diarrhoea for years long and there is renewed interest from the discovery of novel compounds from plants to flight against diarrhoea. WHO also encourages studies on diarrhoea which include research on traditional herbs. The present study was designed to investigate antidiarrhoeal potential of leaf extracts of Ocimum sanctum (Lamiaceae. The present study is aimed to evaluate the leaf extracts of Ocimum sanctum (Lamiaceae) for acclaimed anti-diarrhoeal activity using albino rats. Anti-diarrhoeal activity of Ocimum sanctum was evaluated by castor oil-induced diarrhoea in rats. Loperamide was used as a standard drug. The study revealed that, the alcoholic extract and aqueous extract of Ocimum sanctum possessed significant antidiarrhoeal activity in castor oil-induced diarrhoea, compared to the control group. Ocimum sanctum showed significant anti-diarrhoeal activity as compared to loperamide and can be recommended for further...
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Posted by admin on Oct 31, 2015 in |
Background: The Influenza viruses are major etiologic agents of human respiratory infections, and inflict sizable health and economic burden. Methods: The present study reports the in-vitro antiviral effect of isolated alkaloidal compound of Jatropha curcas leaves against Influenza virus by Hemagglutination (HA) reduction assay in two different layouts of simultaneous and post-treatment assay. The alkaloidal compound was used for anti-influenza activity in the non-cytotoxic range. The separated compound (Rf 0.5) was eluted, crystallised and identified by using NMR and FTIR analysis and co-TLC with standard compound of Tetra Methyl Pyrazine(TMP). Results: The Thin Layer Chromatographic analysis showed that ethyl acetate: dichloromethane (1:1) was the best solvent for alkaloidal separation. The identified Tetra-Methyl Pyrazine showed 100% reduction in HA in the post-treatment assays at the concentration of 10mg/ml and 5mg/ml. In simultaneous assay, HA was reduced to 71% and 42% at concentration of 10mg/ml and 5mg/ml respectively. Conclusions: These results suggest that TMP has strong anti-Influenza virus activity that can inhibit viral attachment and/or viral replication and may be used...
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Posted by admin on Oct 31, 2015 in |
The aim of the present study is to evaluate the protective effect of flower extract of Michelia champaca on membrane bound enzyme (serum ATPase) levels on male albino rats. The membrane bound enzymes (Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase) levels of methanolic flower extract of Michelia champaca at a dose of 300 mg/kg was evaluated during exposure to CCl4. There was a significant decrease in membrane bound enzymes such as Ca2+ ATPase, Mg2+ ATPase, Na+K+ ATPase was observed in CCl4 treated rats. Therapeutic treatment with plant extract has significantly ameliorated to near normalcy in the curative group. These results of the study concluded that Michelia champaca was found to be effective in preventing the biochemical abnormalities caused by...
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Posted by admin on Oct 31, 2015 in |
Montelukast sodium is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies1-2. Montelukast comes as a tablet, a chewable tablet, and granules to take by mouth3. Montelukast is usually taken once a day with or without food3. The present study describes a simple, accurate reproducible and precise uv spectrophotometric method for the estimation of Montelukast Sodium in bulk and in tablet dosage form. The absorbance maxima (λmax) for Montelukast Sodium were found to be 286.5nm. The method was validated for different parameters such as molar absorptivity, accuracy precision, ruggedness, robustness, detection limit, quantification limit etc, (as per ICH guidelines). The relative standard deviation (RSD) in case of, accuracy precision, ruggedness, robustness was less than 2.0% proving that method was highly accurate, precise and robust. This method can be used for determination of Montelukast Sodium in pharmaceutical formulations without interference of the...
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